Unlocking the therapeutic potential of Geraniol: an alternative perspective for metabolic disease management

Amvam Zollo PH, Abondo R, Biyiti L, Menut C, Bessière JM (2002) Aromatic plants of Tropical Central Africa XXXVIII: Chemical composition of the essential oils from four Aframomum species collected in Cameroon (1). J Essent Oil Res 14(2):95–98

Article  Google Scholar 

Anugu A, Belford A, Gregson C, Diblasio K, Symczak K, Sundaresan K, Wansor R (2024) Beverages including steviol glycosides and a foam suppressing agent. Google Patents.

Bagheri S, Rashno M, Salehi I, Karimi SA, Raoufi S, Komaki A (2023) Geraniol improves passive avoidance memory and hippocampal synaptic plasticity deficits in a rat model of Alzheimer’s disease. Eur J Pharmacol 951:175714

Article  CAS  PubMed  Google Scholar 

Bahreininejad B, Mirza M, Arzani A (2010) Essential oil variation in Thymus daenensis subsp. daenensis Cleak populations. J Essent Oil Res 22(1):48–51

Article  CAS  Google Scholar 

Baser KHC, Kürkçüoglu M, Demirci B (2005) Ninde oil (Aeollanthus myrianthus Taylor) revisited: analysis of a historical oil. J Essent Oil Res 17(2):137–138

Article  Google Scholar 

Brumar D, Fard MA, Geiling B, Manjili MH (2023) Methods of synthesizing cannabigergol, cannabigerolic acid, and analogs thereof. Google Patents.

Campos EVR, Proença PLF, Oliveira JL, Pereira AES, De Morais Ribeiro LN, Fernandes FO, Gonçalves KC, Polanczyk RA, Pasquoto-Stigliani T, Lima R, Melville CC, Della Vechia JF, Andrade DJ, Fraceto LF (2018) Carvacrol and linalool co-loaded in β-cyclodextrin-grafted chitosan nanoparticles as sustainable biopesticide aiming pest control. Sci Rep 8(1):1–14. https://doi.org/10.1038/s41598-018-26043-x

Article  CAS  Google Scholar 

Can S, Canbek M (2019) Protective effects of geraniol on long term renal ischemia/reperfusion injury in rats. Braz Arch Biol Technol 62:e19180438

Article  CAS  Google Scholar 

Chand S, Tripathi AS, Hasan T, Ganesh K, Cordero MAW, Yasir M, Zaki MEA, Tripathi P, Mohapatra L, Maurya RK (2023) Geraniol reverses obesity by improving conversion of WAT to BAT in high fat diet induced obese rats by inhibiting HMGCoA reductase. Nutr Diabetes 13(1):26

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chauhan A, Verma RS, Padalia RC, Upadhyay RK, Bahl JR (2016) Post harvest storage effect on essential oil content and composition of Cymbopogon distans (Nees ex Steud.) Wats. J Essent Oil Res 28(6):540–544

Article  CAS  Google Scholar 

Chen W, Viljoen AM (2022) Geraniol–a review update. S Afr J Bot 150:1205–1219

Article  CAS  Google Scholar 

Choi SJ, Ye SB, Na HG, Kim GO, Bae CH, Song SY, Kim YW, Park SY, Kim YD (2011) Effect of geranium essential oil on food intake via olfactory stimulus. Korean J Otorhinolaryngol-Head Neck Surg 54(11):766

Article  Google Scholar 

Chorianopoulos N, Kalpoutzakis E, Aligiannis N, Mitaku S, Nychas G-J, Haroutounian SA (2004) Essential oils of Satureja, Origanum, and Thymus species: chemical composition and antibacterial activities against foodborne pathogens. J Agric Food Chem 52(26):8261–8267

Article  CAS  PubMed  Google Scholar 

Cornier M-A, Dabelea D, Hernandez TL, Lindstrom RC, Steig AJ, Stob NR, Van Pelt RE, Wang H, Eckel RH (2008) The metabolic syndrome. Endocr Rev 29(7):777–822

Article  CAS  PubMed  PubMed Central  Google Scholar 

Crespo R, Rodenak-Kladniew BE, Castro MA, Soberón MV, Lavarias SML (2020) Induction of oxidative stress as a possible mechanism by which geraniol affects the proliferation of human A549 and HepG2 tumor cells. Chem Biol Interact 320:109029

Article  CAS  PubMed  Google Scholar 

da Silva AA, do Carmo JM, Li X, Wang Z, Mouton AJ, Hall JE (2020) Role of hyperinsulinemia and insulin resistance in hypertension: metabolic syndrome revisited. Can J Cardiol 36(5):671–682

Article  PubMed  Google Scholar 

de Andrade LRM, Guilger-Casagrande M, Germano-Costa T, de Lima R (2022) Polymeric nanorepellent systems containing geraniol and icaridin aimed at repelling Aedes aegypti. Int J Mol Sci 23(15):8317

Article  PubMed  PubMed Central  Google Scholar 

Ekonomou SI, Akshay Thanekar P, Lamprou DA, Weaver E, Doran O, Stratakos AC (2022) Development of geraniol-loaded liposomal nanoformulations against salmonella colonization in the pig gut. J Agric Food Chem 70(23):7004–7014

Article  CAS  PubMed  PubMed Central  Google Scholar 

El-Bassossy HM, Elberry AA, Ghareib SA (2016) Geraniol improves the impaired vascular reactivity in diabetes and metabolic syndrome through calcium channel blocking effect. J Diabetes Complicat 30(6):1008–1016

Article  Google Scholar 

El-Bassossy HM, Ghaleb H, Elberry AA, Balamash KS, Ghareib SA, Azhar A, Banjar Z (2017) Geraniol alleviates diabetic cardiac complications: effect on cardiac ischemia and oxidative stress. Biomed Pharmacother 88:1025–1030

Article  CAS  PubMed  Google Scholar 

El-Emam SZ, Soubh AA, Al-Mokaddem AK, Abo El-Ella DM (2020) Geraniol activates Nrf-2/HO-1 signaling pathway mediating protection against oxidative stress-induced apoptosis in hepatic ischemia-reperfusion injury. Naunyn-Schmiedeberg’s Arch Pharmacol 393:1849–1858

Article  CAS  Google Scholar 

El-Said YAM, Sallam NAA, Ain-Shoka AA-M, Abdel-Latif HA-T (2020) Geraniol ameliorates diabetic nephropathy via interference with miRNA-21/PTEN/Akt/mTORC1 pathway in rats. Naunyn-Schmiedeberg’s Arch Pharmacol 393:2325–2337

Article  CAS  Google Scholar 

El Azab EF, Abdulmalek S (2022) Amelioration of age-related multiple neuronal impairments and inflammation in high-fat diet-fed rats: the prospective multitargets of geraniol. Oxidative Medicine and Cellular Longevity, 2022.

Eskandari N, Bahramikia S, Mohammadi A, Taati M, Jafarabad SS (2022) Geraniol ameliorated serum lipid profile and improved antioxidant defense system in pancreas, liver and heart tissues of alloxan-induced diabetic rats. Biologia. https://doi.org/10.1007/s11756-021-00925-4

Article  Google Scholar 

Esposito K, Giugliano D (2004) The metabolic syndrome and inflammation: association or causation? In: nutrition, metabolism and cardiovascular diseases issue 5, vol 14. Elsevier, New York, pp 228–232

Google Scholar 

Fahed G, Aoun L, Bou Zerdan M, Allam S, Bou Zerdan M, Bouferraa Y, Assi HI (2022) Metabolic syndrome: updates on pathophysiology and management in 2021. Int J Mol Sci 23(2):786

Article  CAS  PubMed  PubMed Central  Google Scholar 

Farokhcheh M, Hejazian L, Akbarnejad Z, Pourabdolhossein F, Hosseini SM, Mehraei TM, Soltanpour N (2021) Geraniol improved memory impairment and neurotoxicity induced by zinc oxide nanoparticles in male wistar rats through its antioxidant effect. Life Sci 282:119823

Article  CAS  PubMed  Google Scholar 

Feng X, Feng K, Zheng Q, Tan W, Zhong W, Liao C, Liu Y, Li S, Hu W (2022) Preparation and characterization of geraniol nanoemulsions and its antibacterial activity. Front Microbiol 13:1080300

Article  PubMed  PubMed Central  Google Scholar 

Fuselli SR, de la Rosa BG, Eguaras MJ, Fritz R (2010) In vitro antibacterial effect of exotic plants essential oils on the honeybee pathogen Paenibacillus larvae, causal agent of American foulbrood. Span J Agric Res 8(3):651–657

Article  Google Scholar 

Gleeson MP, Leeson PD, van de Waterbeemd H (2015) Physicochemical properties and compound quality in the handbook of medicinal chemistry: principles and practice.In: A. Davis and SE Ward (ed) Royal Society of Chemistry.

Goto T, Takahashi N, Hirai S, Kawada T (2010) Various terpenoids derived from herbal and dietary plants function as PPAR modulators and regulate carbohydrate and lipid metabolism. PPAR Research, 2010.

Grison C, Stanovych A (2022) Mosquito repellent composition and method for the preparation thereof. Google Patents.

Hadian Z, Maleki M, Abdi K, Atyabi F, Mohammadi A, Khaksar R (2018) Preparation and characterization of nanoparticle β-cyclodextrin: geraniol inclusion complexes. Iran J Pharm Res IJPR 17(1):39

CAS  PubMed  Google Scholar 

Hashemi P, Abolghasemi MM, Hassanvand H, Ahmadi S (2010) Headspace solvent microextraction of volatile components of Thymus daenensis. J Essent Oil Res 22(4):365–368

Article  CAS  Google Scholar 

Heindel JJ, Blumberg B, Cave M, Machtinger R, Mantovani A, Mendez MA, Nadal A, Palanza P, Panzica G, Sargis R (2017) Metabolism disrupting chemicals and metabolic disorders. Reprod Toxicol 68:3–33

Article  CAS  PubMed  Google Scholar 

Henao-Mejia J, Elinav E, Thaiss CA, Flavell RA (2014) Inflammasomes and metabolic disease. Annu Rev Physiol 76:57–78

Article  CAS  PubMed  Google Scholar 

Ibrahim SM, El-Denshary ES, Abdallah DM (2015) Geraniol, alone and in combination with pioglitazone, ameliorates fructose-induced metabolic syndrome in rats via the modulation of both inflammatory and oxidative stress status. PLoS ONE 10(2):e0117516

Article  PubMed  PubMed Central  Google Scholar 

Jäger T, Koch HM, Leibold E, Bader M (2023) Human metabolism and urinary elimination kinetics of the fragrance geraniol after oral dosage. Chem Res Toxicol 36(11):1745–1752

Article  PubMed  Google Scholar 

留言 (0)

沒有登入
gif