Açar Y, Ağagündüz D, De Cicco P, Capasso R (2023) Flavonoids: Their putative neurologic roles, epigenetic changes, and gut microbiota alterations in Parkinson’s disease. Biomed Pharmacother 168:115788

Article  PubMed  Google Scholar 

Ağagündüz D, Gençer Bingöl F, Çelik E, Cemali Ö, Özenir Ç, Özoğul F, Capasso R (2022) Recent developments in the probiotics as live biotherapeutic products (LBPs) as modulators of gut brain axis related neurological conditions. J Transl Med 20:460

Article  PubMed  PubMed Central  Google Scholar 

Ağagündüz D, Çelik E, Cemali Ö, Bingöl FG, Özenir Ç, Özoğul F, Capasso R (2023a) Probiotics, Live Biotherapeutic Products (LBPs), and Gut-Brain Axis Related Psychological Conditions: Implications for Research and Dietetics. Probiotics Antimicrob Proteins 15:1014–1031

Article  PubMed  Google Scholar 

Ağagündüz D, Cocozza E, Cemali Ö, Bayazit AD, Nanì MF, Cerqua I, Morgillo F, Saygili SK, Berni Canani R, Amero P, Capasso R (2023b) Understanding the role of the gut microbiome in gastrointestinal cancer: a review. Front Pharmacol 14:1130562

Article  PubMed  PubMed Central  Google Scholar 

Ağagündüz D, Icer MA, Yesildemir O, Koçak T, Kocyigit E, Capasso R (2023c) The roles of dietary lipids and lipidomics in gut-brain axis in type 2 diabetes mellitus. J Transl Med 21:240

Article  PubMed  PubMed Central  Google Scholar 

Aghamiri H, Shafaroodi H, Asgarpanah J (2020) Anticonvulsant activity of essential oil from leaves of Zhumeria majdae (Rech.) in mice: the role of GABAA neurotransmission and the nitric oxide pathway. Clin Transl Sci 13:785–797

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aghamiri H, Jafari-SABET M, Hoormand M (2024) Ameliorative Effect of Cannabidiol on Topiramate-Induced Memory Loss: the role of hippocampal and prefrontal cortical NMDA receptors and CREB/BDNF signaling pathways in rats. Neurochem Res 49:363–378

Article  CAS  PubMed  Google Scholar 

Ali MR, Reza A, Haque MA, Islam MJ, Hossain MR, Mollah MI, Islam MB, Sarker J, Rashid M, Sadik MG, Cicia D, Capasso R, Kazi M, Alam AK (2024) Exploring the therapeutic potential of edible vegetables, fruits, and spices against cancer in various cell lines. J Cancer 15:577–589

Article  CAS  PubMed  PubMed Central  Google Scholar 

Althagafy HS, Ali FE, Hassanein EH, Mohammedsaleh ZM, El-Sayed MIK, Atwa AM, Sayed AM, Soubh AA (2023) Canagliflozin ameliorates ulcerative colitis via regulation of TLR4/MAPK/NF-κB and Nrf2/PPAR-γ/SIRT1 signaling pathways. Eur J Pharmacol 960:176166

Article  CAS  PubMed  Google Scholar 

Bai, X.-S., Bai, G., Tang, L.-D., Li, Y., HUAN, Y. & WANG, H. 2020. MiR-195 alleviates ulcerative colitis in rats via MAPK signaling pathway. European Review for Medical & Pharmacological Sciences, 24.

Baumgart DC, Sandborn WJ (2007) Inflammatory bowel disease: clinical aspects and established and evolving therapies. The Lancet 369:1641–1657

Article  CAS  Google Scholar 

Baydi Z, Limami Y, Khalki L, Zaid N, Naya A, Mtairag EM, Oudghiri M, Zaid Y (2021) An update of research animal models of inflammatory bowel disease. ScientificWorldJournal 2021:7479540

Article  PubMed  PubMed Central  Google Scholar 

Biltekin SN, Karadaĝ AEE, Demirci BL, Demirci F (2022) ACE2 and LOX enzyme inhibitions of different lavender essential oils and major components linalool and camphor. ACS Omega 7:36561–36566

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bonay M, Deramaudt T (2015) Nrf2: new insight in cell apoptosis. Cell Death Dis 6:e1897

Article  CAS  PubMed  PubMed Central  Google Scholar 

Broom O, Widjaya B, Troelsen J, Olsen J, Nielsen O (2009) Mitogen activated protein kinases: a role in inflammatory bowel disease? Clin Exp Immunol 158:272–280

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai Z, Wang S, Li J (2021) Treatment of inflammatory bowel disease: a comprehensive review. Front Med 8:765474

Article  Google Scholar 

Cerqua I, Neukirch K, Terlizzi M, Granato E, Caiazzo E, Cicala C, Ialenti A, Capasso R, Werz O, Sorrentino R, Seraphin D, Helesbeux JJ, Cirino G, Koeberle A, Roviezzo F, Rossi A (2022) A vitamin E long-chain metabolite and the inspired drug candidate α-amplexichromanol relieve asthma features in an experimental model of allergen sensitization. Pharmacol Res 181:106250

Article  CAS  PubMed  Google Scholar 

D’avino D, Cerqua I, Ullah H, Spinelli M, Di Matteo R, Granato E, Capasso R, Maruccio L, Ialenti A, Daglia M, Roviezzo F, Rossi A (2023) Beneficial effects of Astragalus membranaceus (Fisch.) bunge extract in controlling inflammatory response and preventing asthma features. Int J Mol Sci 24:10954

Article  PubMed  PubMed Central  Google Scholar 

Dong J, Wang H, Zhao J, Sun J, Zhang T, Zuo L, Zhu W, Gong J, Li Y, Gu L (2015) SEW2871 protects from experimental colitis through reduced epithelial cell apoptosis and improved barrier function in interleukin-10 gene-deficient mice. Immunol Res 61:303–311

Article  CAS  PubMed  Google Scholar 

Fairbrass KM, Costantino SJ, Gracie DJ, Ford AC (2020) Prevalence of irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease in remission: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol 5:1053–1062

Article  PubMed  Google Scholar 

Farid A, Sheibani M, Shojaii A, Noori M, Motevalian M (2022) Evaluation of anti-inflammatory effects of leaf and seed extracts of Plantago major on acetic acid-induced ulcerative colitis in rats. J Ethnopharmacol 298:115595

Article  CAS  PubMed  Google Scholar 

Feng YJ, Li YY (2011) The role of p38 mitogen-activated protein kinase in the pathogenesis of inflammatory bowel disease. J Dig Dis 12:327–332

Article  CAS  PubMed  Google Scholar 

Ferrarini EG, Paes RS, Baldasso GM, De Assis PM, Gouvêa MC, Cicco P, Raposo NRB, Capasso R, Moreira ELG, Dutra RC (2022) Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice. Biomed Pharmacother 154:113552

Article  CAS  PubMed  Google Scholar 

Fonseca-Camarillo G, Yamamoto-Furusho JK (2015) Immunoregulatory pathways involved in inflammatory bowel disease. Inflamm Bowel Dis 21:2188–2193

Article  PubMed  Google Scholar 

Ge L, Liu S, Li S, Yang J, Hu G, Xu C, Song W (2022) Psychological stress in inflammatory bowel disease: Psychoneuroimmunological insights into bidirectional gut-brain communications. Front Immunol 13:1016578

Article  CAS  PubMed  PubMed Central  Google Scholar 

Govaerts R (2009) World checklist of selected plant families. Royal Botanic Gardens

Google Scholar 

Gu P, Zhu L, Liu Y, Zhang L, Liu J, Shen H (2017) Protective effects of paeoniflorin on TNBS-induced ulcerative colitis through inhibiting NF-kappaB pathway and apoptosis in mice. Int Immunopharmacol 50:152–160

Article  CAS  PubMed  Google Scholar 

Hollenbach E, Neumann M, Vieth M, Roessner A, Malfertheiner P, Naumann M (2004) Inhibition of p38 MAP kinase-and RICK/NF-κB-signaling suppresses inflammatory bowel disease. FASEB J 18:1550–1552

Article  CAS  PubMed  Google Scholar 

Hosseinzadeh H, Ramezani M, Fadishei M, Mahmoudi M (2002) Antinociceptive, anti-inflammatory and acute toxicity effects of Zhumeria majdae extracts in mice and rats. Phytomedicine 9:135–141

Article  CAS  PubMed  Google Scholar 

Kalkan H, Pagano E, Paris D, Panza E, Cuozzo M, Moriello C, Piscitelli F, Abolghasemi A, Gazzerro E, Silvestri C, Capasso R, Motta A, Russo R, Di Marzo V, Iannotti FA (2023) Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy. EMBO Mol Med 15:e16225

Article  CAS  PubMed  PubMed Central  Google Scholar 

Katsanos KH, Papadakis KA (2017) Inflammatory bowel disease: updates on molecular targets for biologics. Gut and Liver 11:455

Article  CAS  PubMed  PubMed Central