Acker T, Acker H (2004) Cellular oxygen sensing need in CNS function: physiological and pathological implications. J Exp Biol 207(18):3171–3188. https://doi.org/10.1242/jeb.01075

Article  CAS  PubMed  Google Scholar 

Ahmad A, Patel V, Xiao J, Khan MM (2020) The role of neurovascular system in neurodegenerative diseases. Mol Neurobiol 57:4373–4393. https://doi.org/10.1007/s12035-020-02023-z

Article  CAS  PubMed  Google Scholar 

Albadari N, Deng S, Li W (2019) The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy. Expert Opin Drug Discov 14(7):667–682. https://doi.org/10.1080/17460441.2019.1613370

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alexander C, Li T, Hattori Y, Chiu D, Frost GR, Jonas L, Li YM (2022) Hypoxia inducible factor-1α binds and activates γ-secretase for Aβ production under hypoxia and cerebral hypoperfusion. Mol Psychiatry 27(10):4264–4273. https://doi.org/10.1038/s41380-022-01676-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Auer RN, Sutherland GR (2002) Hypoxia and Related Conditions. Greenfield’s Neuropathol 1:233–280

Google Scholar 

Belenichev IF, Aliyeva OG, Popazova OO, Bukhtiyarova NV (2023) Involvement of heat shock proteins HSP70 in the mechanisms of endogenous neuroprotection: the prospect of using HSP70 modulators. Front Cell Neurosci 17:1131683. https://doi.org/10.3389/fncel.2023.1131683

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benilova I, Karran E, De Strooper B (2012) The toxic Aβ oligomer and alzheimer’s disease: an emperor in need of clothes. Nat Neurosci 15(3):349–357. https://doi.org/10.1038/nn.3028

Article  CAS  PubMed  Google Scholar 

Bersten DC, Sullivan AE, Peet DJ, Whitelaw ML (2013) bHLH–PAS proteins in cancer. Nat Rev Cancer 13(12):827–841. https://doi.org/10.1038/nrc3621

Article  CAS  PubMed  Google Scholar 

Bloch K, Vennäng J, Lazard D, Vardi P (2012) Different susceptibility of rat pancreatic alpha and beta cells to hypoxia. Histochem Cell Biol 137:801–810. https://doi.org/10.1007/s00418-012-0925-4

Article  CAS  PubMed  Google Scholar 

Chai X, Kong W, Liu L, Yu W, Zhang Z, Sun Y (2014) A viral vector expressing hypoxia-inducible factor 1 alpha inhibits hippocampal neuronal apoptosis. Neural Regen Res 9(11):1145–1153. https://doi.org/10.4103/1673-5374.135317

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM, Schumacker PT (2000) Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia: a mechanism of O2 sensing. J Biol Chem 275(33):25130–25138. https://doi.org/10.1074/jbc.M001914200

Article  CAS  PubMed  Google Scholar 

Chen R, Lai UH, Zhu L, Singh A, Ahmed M, Forsyth NR (2018) Reactive oxygen species formation in the brain at different oxygen levels: the role of hypoxia inducible factors. Front Cell Develop Biol 6:132. https://doi.org/10.3389/fcell.2018.00132

Article  Google Scholar 

Cheng Y, Tian DY, Wang YJ (2020) Peripheral clearance of brain-derived Aβ in Alzheimer's disease: pathophysiology and therapeutic perspectives. Transl Neurodegener 9:1–11

Article  CAS  Google Scholar 

de Lemos ML, dela Torre, A V, Petrov D, Brox S, Folch J, Pallàs M, Camins A, (2013) Evaluation of hypoxia inducible factor expression in inflammatory and neurodegenerative brain models. Int J Biochem Cell Biol 45(7):1377–1388. https://doi.org/10.1016/j.biocel.2013.04.011

Article  CAS  PubMed  Google Scholar 

Engelhardt S, Patkar S, Ogunshola OO (2014a) Cell-specific blood–brain barrier regulation in health and disease: a focus on hypoxia. Br J Pharmacol 171(5):1210–1230. https://doi.org/10.1111/bph.12489

Article  CAS  PubMed  PubMed Central  Google Scholar 

Engelhardt S, Al-Ahmad AJ, Gassmann M, Ogunshola OO (2014b) Hypoxia selectively disrupts brain microvascular endothelial tight junction complexes through a hypoxia-inducible factor-1 (HIF-1) dependent mechanism. J Cell Physiol 229(8):1096–1105. https://doi.org/10.1002/jcp.24544

Article  CAS  PubMed  Google Scholar 

Franco GA, Interdonato L, Cordaro M, Cuzzocrea S, Di Paola R (2023) Bioactive compounds of the mediterranean diet as nutritional support to fight neurodegenerative disease. Int J Mol Sci 24(8):7318. https://doi.org/10.3390/ijms24087318

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gianferrara T, Cescon E, Grieco I, Spalluto G, Federico S (2022) Glycogen synthase kinase 3β involvement in neuroinflammation and neurodegenerative diseases. Curr Med Chem 29(27):4631–4697. https://doi.org/10.2174/0929867329666220216113517

Article  CAS  PubMed  Google Scholar 

Goda N, Dozier SJ, Johnson RS (2003) HIF-1 in cell cycle regulation, apoptosis, and tumor progression. Antioxid Redox Signal 5(4):467–473. https://doi.org/10.1089/152308603768295212

Article  CAS  PubMed  Google Scholar 

Gupta R, Tongers J, Losordo DW (2009) Human studies of angiogenic gene therapy. Circ Res 105(8):724–736. https://doi.org/10.1161/CIRCRESAHA.109.200386

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hai Y, Ren K, Zhang Y, Yang L, Cao H, Yuan X, Liu D (2024) HIF-1α serves as a co-linker between AD and T2DM. Biomed Pharmacother 171:116158. https://doi.org/10.1016/j.biopha.2024.116158

Article  CAS  PubMed  Google Scholar 

Hofer T, Wenger RH, Gassmann M (2002) Oxygen sensing, HIF-1α stabilization and potential therapeutic strategies. Pflügers Archiv: European J Physiol 443(4):503. https://doi.org/10.1007/s00424-001-0759-8

Article  CAS  Google Scholar 

Ikeda H, Kakeya H (2021) Targeting hypoxia-inducible factor 1 (HIF-1) signaling with natural products toward cancer chemotherapy. J Antibiot 74(10):687–695. https://doi.org/10.1038/s41429-021-00451-0

Article  CAS  Google Scholar 

Islam MT (2017) Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders. Neurol Res 39(1):73–82. https://doi.org/10.1080/01616412.2016.1251711

Article  CAS  PubMed  Google Scholar 

Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Kaelin WG Jr (2001) HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292(5516):464–468. https://doi.org/10.1126/science.1059817

Article  CAS  PubMed  Google Scholar 

Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, Ratcliffe PJ (2001) Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292(5516):468–472. https://doi.org/10.1126/science.1059796

Article  CAS  PubMed  Google Scholar 

Jha NK, Jha SK, Sharma R, Kumar D, Ambasta RK, Kumar P (2018) Hypoxia-induced signaling activation in neurodegenerative diseases: targets for new therapeutic strategies. J Alzheimers Dis 62(1):15–38. https://doi.org/10.3233/JAD-170589

Article  CAS  PubMed  Google Scholar 

Kerridge C, Kozlova DI, Nalivaeva NN, Turner AJ (2015) Hypoxia affects neprilysin expression through caspase activation and an APP intracellular domain-dependent mechanism. Front Neurosci 9:426. https://doi.org/10.3389/fnins.2015.00426

Article  PubMed  PubMed Central  Google Scholar 

Kim S, Lee M, Choi YK (2020) The role of a neurovascular signaling pathway involving hypoxia-inducible factor and notch in the function of the central nervous system. Biomole Therapeut 28(1):45.