Albrethsen J, Angeletti RH, Horwitz SB, Yang CPH (2014) Proteomics of cancer cell lines resistant to microtubule-stabilizing agents. Mol Cancer Ther 13:260–269. https://doi.org/10.1158/1535-7163.MCT-13-0471

Article  CAS  PubMed  Google Scholar 

Banerjee R, Pennington MW, Garza A, Owens IS (2008) Mapping the UDP-glucuronic acid binding site in UDP-glucuronosyltransferase-1A10 by homology-based modeling: confirmation with biochemical evidence. Biochemistry 47:7385–7392. https://doi.org/10.1021/BI8006127

Article  CAS  PubMed  Google Scholar 

Bateman A, Martin MJ, Orchard S et al (2021) UniProt: the universal protein knowledgebase in 2021. Nucleic Acids Res 49:D480–D489. https://doi.org/10.1093/NAR/GKAA1100

Article  Google Scholar 

Bellemare J, Rouleau M, Girard H et al (2010a) Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro. Drug Metab Dispos 38:1785–1789. https://doi.org/10.1124/DMD.110.034835

Article  CAS  PubMed  Google Scholar 

Bellemare J, Rouleau M, Harvey M, Guillemette C (2010b) Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein–protein interactions. J Biol Chem 285:3600–3607. https://doi.org/10.1074/JBC.M109.083139

Article  CAS  PubMed  Google Scholar 

Bock KW, Köhle C (2009) Topological aspects of oligomeric UDP-glucuronosyltransferases in endoplasmic reticulum membranes: advances and open questions. Biochem Pharmacol 77:1458–1465. https://doi.org/10.1016/J.BCP.2008.12.004

Article  CAS  PubMed  Google Scholar 

Breton C, Šnajdrová L, Jeanneau C et al (2006) Structures and mechanisms of glycosyltransferases. Glycobiology 16(2):29R-37R

Article  CAS  PubMed  Google Scholar 

Bueschbell B, Caniceiro AB, Suzano PMS et al (2022) Network biology and artificial intelligence drive the understanding of the multidrug resistance phenotype in cancer. Drug Resist Updat 60:100811

Article  CAS  PubMed  Google Scholar 

Chau N, Elliot DJ, Lewis BC et al (2014) Morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7: kinetic, inhibition, and molecular modeling studies. J Pharmacol Exp Ther 349:126–137. https://doi.org/10.1124/JPET.113.212258

Article  PubMed  Google Scholar 

Cheng Y (2018) Single-particle cryo-EM-How did it get here and where will it go. Science 361:876–880. https://doi.org/10.1126/SCIENCE.AAT4346

Article  CAS  PubMed  PubMed Central  Google Scholar 

Court MH, Zhang X, Ding X et al (2012) Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues. Xenobiotica 42:266–277. https://doi.org/10.3109/00498254.2011.618954

Article  CAS  PubMed  Google Scholar 

Dimunová D, Matoušková P, Podlipná R et al (2022) The role of UDP-glycosyltransferases in xenobioticresistance. Drug Metab Rev 54:282–298. https://doi.org/10.1080/03602532.2022.2083632

Article  CAS  PubMed  Google Scholar 

Fujiwara R, Nakajima M, Oda S et al (2010) Interactions between human UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes. J Pharm Sci 99:442–454. https://doi.org/10.1002/JPS.21830

Article  CAS  PubMed  Google Scholar 

Fujiwara R, Yokoi T, Nakajima M (2016) Structure and Protein–protein Interactions of Human UDP-Glucuronosyltransferases. Front Pharmacol 7:388

Article  CAS  PubMed  PubMed Central  Google Scholar 

Galluzzi L, Senovilla L, Vitale I et al (2012) Molecular mechanisms of cisplatin resistance. Oncogene 31:1869–1883. https://doi.org/10.1038/ONC.2011.384

Article  CAS  PubMed  Google Scholar 

Gaynor EC, Te Heesen S, Graham TR et al (1994) Signal-mediated retrieval of a membrane protein from the Golgi to the ER in yeast. J Cell Biol 127:653–665. https://doi.org/10.1083/JCB.127.3.653

Article  CAS  PubMed  Google Scholar 

Guillemette C, Lévesque É, Rouleau M (2014) Pharmacogenomics of human uridine diphospho-glucuronosyltransferases and clinical implications. Clin Pharmacol Ther 96:324–339. https://doi.org/10.1038/CLPT.2014.126

Article  CAS  PubMed  Google Scholar 

Habtewold A, Amogne W, Makonnen E et al (2011) Long-term effect of efavirenz autoinduction on plasma/peripheral blood mononuclear cell drug exposure and CD4 count is influenced by UGT2B7 and CYP2B6 genotypes among HIV patients. J Antimicrob Chemother 66:2350–2361. https://doi.org/10.1093/JAC/DKR304

Article  CAS  PubMed  Google Scholar 

Hamada S, Taguchi K, Masamune A et al (2017) Nrf2 promotes mutant K-ras/p53-driven pancreatic carcinogenesis. Carcinogenesis 38:661–670. https://doi.org/10.1093/CARCIN/BGX043

Article  CAS  PubMed  Google Scholar 

He BX, Qiao B, Lam AKY et al (2018) Association between UDP-glucuronosyltransferase 2B7 tagSNPs and breast cancer risk in Chinese females. Clin Exp Pharmacol Physiol 45:437–443. https://doi.org/10.1111/1440-1681.12908

Article  CAS  PubMed  Google Scholar 

Hu DG, Mackenzie PI, McKinnon RA, Meech R (2016a) Genetic polymorphisms of human UDP-glucuronosyltransferase (UGT) genes and cancer risk. Drug Metab Rev 48:47–69. https://doi.org/10.3109/03602532.2015.1131292

Article  CAS  PubMed  Google Scholar 

Hu DG, Selth LA, Tarulli GA et al (2016b) Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17. Cancer Res 76:5881–5893. https://doi.org/10.1158/0008-5472.CAN-15-3372

Article  CAS  PubMed  Google Scholar 

Hu DG, Hulin J, ulie A, Nair PC et al (2019) The UGTome: The expanding diversity of UDP glycosyltransferases and its impact on small molecule metabolism. Pharmacol Ther 204:107414

Article  CAS  PubMed  Google Scholar 

Hu DG, Marri S, Mackenzie PI et al (2021) The Expression Profiles and Deregulation of UDP-Glycosyltransferase ( UGT) Genes in Human Cancers and Their Association with Clinical Outcomes. Cancers (Basel) 13(7):4491

Article  CAS  PubMed  Google Scholar 

Hu DG, Marri S, Hulin JA et al (2022) The Somatic Mutation Landscape of UDP-Glycosyltransferase ( UGT) Genes in Human Cancers. Cancers (Basel) 14(22):5708

Article  CAS  PubMed  Google Scholar 

Izumi K, Li Y, Ishiguro H et al (2014) Expression of UDP-glucuronosyltransferase 1A in bladder cancer: association with prognosis and regulation by estrogen. Mol Carcinog 53:314–324. https://doi.org/10.1002/MC.21978

Article  CAS  PubMed  Google Scholar 

Kaimal V, Bardes EE, Tabar SC et al (2010) ToppCluster: a multiple gene list feature analyzer for comparative enrichment clustering and network-based dissection of biological systems. Nucleic Acids Res 38:W96–W102

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karypidis AH, Olsson M, Andersson SO et al (2008) Deletion polymorphism of the UGT2B17 gene is associated with increased risk for prostate cancer and correlated to gene expression in the prostate. Pharmacogenomics J 8:147–151. https://doi.org/10.1038/SJ.TPJ.6500449

Article  CAS  PubMed  Google Scholar 

Kwara A, Lartey M, Boamah I et al (2009) Interindividual variability in pharmacokinetics of generic nucleoside reverse transcriptase inhibitors in TB/HIV-coinfected Ghanaian patients: UGT2B7*1c is associated with faster zidovudine clearance and glucuronidation. J Clin Pharmacol 49:1079–1090. https://doi.org/10.1177/0091270009338482

Article  CAS  PubMed