The emergence of SLE-causing UNC93B1 variants in 2024

Tsokos, G. C. The immunology of systemic lupus erythematosus. Nat. Immunol. 25, 1332–1343 (2024).

Article  PubMed  Google Scholar 

Wolf, C. et al. UNC93B1 variants underlie TLR7-dependent autoimmunity. Sci Immunol 9, eadi9769 (2024).

Article  PubMed  Google Scholar 

Rael, V. E. et al. Large-scale mutational analysis identifies UNC93B1 variants that drive TLR-mediated autoimmunity in mice and humans. J. Exp. Med. 221, e20232005 (2024).

Article  PubMed  PubMed Central  Google Scholar 

Al-Azab, M. et al. Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus. Nat. Immunol. 25, 969–980 (2024).

Article  PubMed  PubMed Central  Google Scholar 

David, C. et al. Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus. J. Exp. Med. 221, e20232066 (2024).

Article  PubMed  PubMed Central  Google Scholar 

Brown, G. J. et al. TLR7 gain-of-function genetic variation causes human lupus. Nature 605, 349–356 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Fitzgerald, K. A. & Kagan, J. C. Toll-like receptors and the control of immunity. Cell 180, 1044–1066 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Majer, O., Liu, B., Kreuk, L. S. M., Krogan, N. & Barton, G. M. UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity. Nature 575, 366–370 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Casrouge, A. et al. Herpes simplex virus encephalitis in human UNC-93B deficiency. Science 314, 308–312 (2006).

Article  PubMed  Google Scholar 

Grammatikos, A. P. & Tsokos, G. C. Immunodeficiency and autoimmunity: lessons from systemic lupus erythematosus. Trends Mol. Med. 18, 101–108 (2012).

Article  PubMed  Google Scholar 

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