Aringer, M. et al. 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus. Arthritis Rheumatol. 71, 1400–1412 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Looney, R. J. et al. B cell depletion as a novel treatment for systemic lupus erythematosus: a phase I/II dose-escalation trial of rituximab. Arthritis Rheum. 50, 2580–2589 (2004).

Article  CAS  PubMed  Google Scholar 

Leandro, M. J., Edwards, J. C., Cambridge, G., Ehrenstein, M. R. & Isenberg, D. A. An open study of B lymphocyte depletion in systemic lupus erythematosus. Arthritis Rheum. 46, 2673–2677 (2002).

Article  PubMed  Google Scholar 

Cohen, S. B. et al. Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum. 54, 2793–2806 (2006).

Article  CAS  PubMed  Google Scholar 

Jones, R. B. et al. Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis. N. Engl. J. Med. 363, 211–220 (2010).

Article  CAS  PubMed  Google Scholar 

Smith, R. M. et al. Rituximab as therapy to induce remission after relapse in ANCA-associated vasculitis. Ann. Rheum. Dis. 79, 1243–1249 (2020).

Article  CAS  PubMed  Google Scholar 

Guillevin, L. et al. Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis. N. Engl. J. Med. 371, 1771–1780 (2014).

Article  PubMed  Google Scholar 

Specks, U. et al. Efficacy of remission-induction regimens for ANCA-associated vasculitis. N. Engl. J. Med. 369, 417–427 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reddy, V. et al. Internalization of rituximab and the efficiency of B cell depletion in rheumatoid arthritis and systemic lupus erythematosus. Arthritis Rheumatol. 67, 2046–2055 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lim, S. H. et al. Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy. Blood 118, 2530–2540 (2011).

Article  PubMed  Google Scholar 

Cole, S. et al. Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus. Arthritis Res. Ther. 20, 85 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Clavarino, G. et al. Novel strategy for phenotypic characterization of human B lymphocytes from precursors to effector cells by flow cytometry. PLoS ONE 11, e0162209 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Álvarez Gómez, J. A. et al. BAFF system expression in double negative 2, activated naïve and activated memory B cells in systemic lupus erythematosus. Front. Immunol. 14, 1235937 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Rodig, S. J., Shahsafaei, A., Li, B., Mackay, C. R. & Dorfman, D. M. BAFF-R, the major B cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disorders. Hum. Pathol. 36, 1113–1119 (2005).

Article  CAS  PubMed  Google Scholar 

Tipton, C. M. et al. Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus. Nat. Immunol. 16, 755–765 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rivero, S. J., Díaz-Jouanen, E. & Alarcón-Segovia, D. Lymphopenia in systemic lupus erythematosus. Clinical, diagnostic, and prognostic significance. Arthritis Rheum. 21, 295–305 (1978).

Article  CAS  PubMed  Google Scholar 

Dörner, T. & Lipsky, P. E. The essential roles of memory B cells in the pathogenesis of systemic lupus erythematosus. Nat. Rev. Rheumatol. 20, 770–782 (2024).

Article  PubMed  Google Scholar 

Odendahl, M. et al. Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus. J. Immunol. 165, 5970–5979 (2000).

Article  CAS  PubMed  Google Scholar 

Liu, M. et al. Type I interferons promote the survival and proinflammatory properties of transitional B cells in systemic lupus erythematosus patients. Cell. Mol. Immunol. 16, 367–379 (2019).

Article  CAS  PubMed  Google Scholar 

Suurmond, J. et al. Patterns of ANA+ B cells for SLE patient stratification. JCI Insight 4, e127885 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Brown, G. J. et al. TLR7 gain-of-function genetic variation causes human lupus. Nature 605, 349–356 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Suurmond, J. et al. Loss of an IgG plasma cell checkpoint in patients with lupus. J. Allergy Clin. Immunol. 143, 1586–1597 (2019).

Article  CAS  PubMed  Google Scholar 

Eckl-Dorna, J. & Batista, F. D. BCR-mediated uptake of antigen linked to TLR9 ligand stimulates B-cell proliferation and antigen-specific plasma cell formation. Blood 113, 3969–3977 (2009).

Article  CAS  PubMed  Google Scholar 

Lau, C. M. et al. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J. Exp. Med. 202, 1171–1177 (2005).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leadbetter, E. A. et al. Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416, 603–607 (2002).

Article  CAS  PubMed  Google Scholar 

Jenks, S. A. et al. Distinct effector B cells induced by unregulated Toll-like receptor 7 contribute to pathogenic responses in systemic lupus erythematosus. Immunity 49, 725–739.e6 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Walsh, E. R. et al. Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity. Proc. Natl Acad. Sci. USA 109, 16276–16281 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wei, C. et al. A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus. J. Immunol. 178, 6624–6633 (2007).

Article  CAS  PubMed  Google Scholar 

Baxter, R. M. et al. Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus. Front. Immunol. 14, 1208282 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sasaki, T. et al. Longitudinal immune cell profiling in patients with early systemic lupus erythematosus. Arthritis Rheumatol. 74, 1808–1821 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lam, J. H. & Baumgarth, N. Toll-like receptor mediated inflammation directs B cells towards protective antiviral extrafollicular responses. Nat. Commun. 14, 3979 (2023).

Article  CAS