All I want for Christmas…is a precisely defined research question

World Health Organization. Ageing and health, https://www.who.int/news-room/fact-sheets/detail/ageing-and-health, Accessed 8 Sept 2024.

May RL. Rudolph the red-nosed reindeer. Chicago, Illinois, United States of America: Montgomery Ward. Applewood Books, U.S.;1939.

Kahan BC, Hindley J, Edwards M, Cro S, Morris TP. The estimands framework: a primer on the ICH E9(R1) addendum. BMJ. 2024;384: e076316.

Article  PubMed  PubMed Central  Google Scholar 

Kahan BC, Morris TP, Cro S. We must let the research question drive study methods. BMJ. 2024;384: q173.

Article  PubMed  Google Scholar 

Cro S, Kahan BC, Rehal S, Chis Ster A, Carpenter JR, White IR, et al. Evaluating how clear the questions being investigated in randomised trials are: systematic review of estimands. BMJ. 2022;378: e070146.

Article  PubMed  PubMed Central  Google Scholar 

Cro S. Time to improve the clarity of clinical trial reports by including estimands. BMJ. 2022;378: o2108.

Article  PubMed  Google Scholar 

Quartagno M, Morris TP, Gilbert DC, Langley RE, Nankivell MG, Parmar MK, et al. A comparison of different population-level summary measures for randomised trials with time-to-event outcomes, with a focus on non-inferiority trials. Clin Trials. 2023;20(6):594–602.

Article  PubMed  PubMed Central  Google Scholar 

Rombach I, Knight R, Peckham N, Stokes JR, Cook JA. Current practice in analysing and reporting binary outcome data—a review of randomised controlled trial reports. BMC Med. 2020;18(1):147.

Article  PubMed  PubMed Central  Google Scholar 

Kahan BC, Morris TP, White IR, Tweed CD, Cro S, Dahly D, et al. Treatment estimands in clinical trials of patients hospitalised for COVID-19: ensuring trials ask the right questions. BMC Med. 2020;18(1):286.

Article  CAS  PubMed  PubMed Central  Google Scholar 

International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use. Addendum on Estimands and Sensitivity Analysis in Clinical Trials to the Guideline on Statistical Principles for Clinical Trials 20 November 2019. https://www.ema.europa.eu/en/documents/scientific-guideline/iche9-r1-addendum-estimands-and-sensitivity-analysis-clinical-trials-guideline-statistical-principles-clinical-trials-step-5_en.pdf.

Cro S, Morris TP, Kahan BC, Cornelius VR, Carpenter JR. A four-step strategy for handling missing outcome data in randomised trials affected by a pandemic. BMC Med Res Methodol. 2020;20(1):208.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Van Lancker K, Tarima S, Bartlett J, Bauer M, Bharani-Dharan B, Bretz F, et al. Estimands and their estimators for clinical trials impacted by the COVID-19 pandemic: a report from the NISS Ingram Olkin Forum Series on unplanned clinical trial disruptions. Statistics in Biopharmaceutical Research. 2023;15(1):94–111.

Article  Google Scholar 

Olarte Parra C, Daniel RM, Bartlett JW. Hypothetical estimands in clinical trials: a unification of causal inference and missing data methods. Stat Biopharm Res. 2023;15(2):421–32.

Article  PubMed  Google Scholar 

Kahan BC, Morris TP, White IR, Carpenter J, Cro S. Estimands in published protocols of randomised trials: urgent improvement needed. Trials. 2021;22(1):686.

Article  PubMed  PubMed Central  Google Scholar 

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