A novel combination of isovanillin, curcumin, and harmine (GZ17-6.02) enhances cell death and alters signaling in actinic keratoses cells when compared to individual components and two-component combinations

aDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland

bDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia, USA

Received 8 April 2022 Revised form accepted 24 April 2022

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Correspondence to Paul Dent, PhD, Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Massey Cancer Center, Box 980035, Richmond, VA 23298 0035, USA, Tel: +804 628 0861; e-mail: [email protected]

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