World Health Organization. Obesity and overweight. Assessed 01 May 2021. Updated 01 April 2020. Available from: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight#:~:text=Worldwide%20obesity%20has%20nearly%20tripled,years%20and%20older%2C%20were%20overweight.&text=39%25%20of%20adults%20aged%2018,kills%20more%20people%20than%20underweight.

World Health Organization. Obesity and overweight. Assessed 01 May 2021. Updated 11 October 2017. Available from: https://www.who.int/news/item/11-10-2017-tenfold-increase-in-childhood-and-adolescent-obesity-in-four-decades-new-study-by-imperial-college-london-and-who.

Bibbins-Domingo K, Coxson P, Pletcher MJ, Lightwood J, Goldman L. Adolescent overweight and future adult coronary heart disease. N EJM. 2007;357(23):2371–9.

Google Scholar 

Baer HJ, Colditz GA, Rosner B, Michels KB, Rich-Edwards JW, Hunter DJ, et al. Body fatness during childhood and adolescence and incidence of breast cancer in premenopausal women: a prospective cohort study. Breast Cancer Res. 2005;7(3):R314–25.

Article  PubMed  PubMed Central  Google Scholar 

Biro FM, Wien M. Childhood obesity and adult morbidities. Am J Clin Nutr. 2010;91(5):1499S-S1505.

Article  PubMed  PubMed Central  Google Scholar 

Lindberg L, Danielsson P, Persson M, Marcus C, Hagman E. Association of childhood obesity with risk of early all-cause and cause-specific mortality: a Swedish prospective cohort study. PLoS Med. 2020;17(3):e1003078.

Article  PubMed  PubMed Central  Google Scholar 

Lindberg L, Hagman E, Danielsson P, Marcus C, Persson M. Anxiety and depression in children and adolescents with obesity: a nationwide study in Sweden. BMC Med. 2020;18(1):30.

Article  PubMed  PubMed Central  Google Scholar 

Caird J, Kavanagh J, Oliver K, Oliver S, O Mara A, Stansfield C, et al., editors. Childhood obesity and educational attainment: a systematic review2011. Retrieved from: https://discovery.ucl.ac.uk/id/eprint/1430001/.

Kroenke K, Spitzer RL, Williams JB, Löwe B. The Patient Health Questionnaire Somatic, Anxiety, and Depressive Symptom Scales: a systematic review. Gen Hosp Psychiatry. 2010;32(4):345–59.

Article  PubMed  Google Scholar 

Kanellopoulou A, Antonogeorgos G, Douros K, Panagiotakos DB. The association between obesity and depression among children and the role of family: a systematic review. Children (Basel). 2022;9(8):1244.

PubMed  PubMed Central  Google Scholar 

World Health Organization. (2022, June). Mental disorders. Retrieved from: https://www.who.int/news-room/fact-sheets/detail/mental-disorders#:~:text=Anxiety%20disorders%20are%20characterised%20by,or%20significant%20impairment%20in%20functioning.

Kalin NH. The critical relationship between anxiety and depression. Am J Psychiatry. 2020;177(5):365–7.

Article  PubMed  Google Scholar 

Jacobson NC, Newman MG. Avoidance mediates the relationship between anxiety and depression over a decade later. J Anxiety Disord. 2014;28(5):437–45.

Article  PubMed  PubMed Central  Google Scholar 

Onyike CU, Crum RM, Lee HB, Lyketsos CG, Eaton WW. Is obesity associated with major depression? Results from the Third National Health and Nutrition Examination Survey. Am J Epidemiol. 2003;158(12):1139–47.

Article  PubMed  Google Scholar 

Scott KM, McGee MA, Wells JE, Oakley Browne MA. Obesity and mental disorders in the adult general population. J Psychosom Res. 2008;64(1):97–105.

Article  PubMed  Google Scholar 

Gariepy G, Nitka D, Schmitz N. The association between obesity and anxiety disorders in the population: a systematic review and meta-analysis. Int J Obes (Lond). 2010;34(3):407–19.

Article  PubMed  Google Scholar 

Jokela M, Laakasuo M. Obesity as a causal risk factor for depression: systematic review and meta-analysis of Mendelian randomization studies and implications for population mental health. J Psychiatr Res. 2023;163:86–92.

Article  PubMed  Google Scholar 

Casanova F, O’Loughlin J, Martin S, Beaumont RN, Wood AR, Watkins ER, et al. Higher adiposity and mental health: causal inference using Mendelian randomization. Hum Mol Genet. 2021;30(24):2371–82.

Article  PubMed  PubMed Central  Google Scholar 

Patalay P, Hardman CA. Comorbidity, codevelopment, and temporal associations between body mass index and internalizing symptoms from early childhood to adolescence. JAMA Psychiat. 2019;76(7):721–9.

Article  Google Scholar 

Quek YH, Tam WWS, Zhang MWB, Ho RCM. Exploring the association between childhood and adolescent obesity and depression: a meta-analysis. Obes Rev. 2017;18(7):742–54.

Article  PubMed  Google Scholar 

Tyrrell J, Mulugeta A, Wood AR, Zhou A, Beaumont RN, Tuke MA, et al. Using genetics to understand the causal influence of higher BMI on depression. Int J Epidemiol. 2019;48(3):834–48.

Article  PubMed  Google Scholar 

Simmonds M, Llewellyn A, Owen C, Woolacott N. Predicting adult obesity from childhood obesity: a systematic review and meta-analysis. Obes Rev. 2015;17:95–107.

Article  PubMed  Google Scholar 

Richardson TG, Sanderson E, Elsworth B, Tilling K, Davey SG. Use of genetic variation to separate the effects of early and later life adiposity on disease risk: Mendelian randomisation study. BMJ. 2020;369:m1203.

Article  PubMed  PubMed Central  Google Scholar 

United Nations International Children's Emergency Fund. (2017, September). Early moments matter for every child. Retrieved from: https://www.unicef.org/early-childhood-development.

Human Early Learning P, Commission on Social Determinants of H. Early child development: a powerful equalizer: final report for the World Health Organization’s Commission on the Social Determinants of Health. / Prepared by Arjumand Siddiqi, Lori G. Irwin, Dr. Clyde Hertzman. Vancouver : Human Early Learning Partnership; 2007. Retrieved from: https://www.who.int/publications/i/item/early-child-development-a-powerful-equalizer-final-report-for-the-world-health-organization-s-commission-on-the-social-determinants-of-health.

Center on the Developing Child at Harvard University. (2010). The foundations of lifelong health are built in early childhood. Retrieved from: http://www.developingchild.harvard.edu.

Sanderson E, Richardson TG, Morris TT, Tilling K, Davey SG. Estimation of causal effects of a time-varying exposure at multiple time points through multivariable Mendelian randomization. PLoS Genet. 2022;18(7):e1010290.

Article  PubMed  PubMed Central  Google Scholar 

Davies NM, Holmes MV, Davey SG. Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ. 2018;362:k601.

Article  PubMed  PubMed Central  Google Scholar 

Sanderson E, Glymour MM, Holmes MV, Kang H, Morrison J, Munafò MR, et al. Mendelian randomization Nat Rev Methods Primers. 2022;2(1):6.

Article  PubMed  Google Scholar 

Casanova F, O’Loughlin J, Martin S, Beaumont RN, Wood AR, Watkins ER, et al. Higher adiposity and mental health: causal inference using Mendelian randomization. Hum Mol Genet. 2021;30(24):2371–82.

Article  PubMed  PubMed Central  Google Scholar 

Wray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A, et al. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet. 2018;50(5):668–81.

Article  PubMed  PubMed Central  Google Scholar 

van den Broek N, Treur JL, Larsen JK, Verhagen M, Verweij KJH, Vink JM. Causal associations between body mass index and mental health: a Mendelian randomisation study. J Epidemiol Community Health. 2018;72(8):708.

Article  PubMed  Google Scholar 

Speed MS, Jefsen OH, Børglum AD, Speed D, Østergaard SD. Investigating the association between body fat and depression via Mendelian randomization. Transl Psychiatry. 2019;9(1):184.

Article  PubMed  PubMed Central  Google Scholar 

Hartwig FP, Bowden J, Loret de Mola C, Tovo-Rodrigues L, Davey Smith G, Horta BL. Body mass index and psychiatric disorders: a Mendelian randomization study. Sci Rep. 2016;6:32730.

Article  PubMed  PubMed Central  Google Scholar 

He C, Zhang M, Li J, Wang Y, Chen L, Qi B, et al. Novel insights into the consequences of obesity: a phenotype-wide Mendelian randomization study. Eur J Hum Genet. 2022;30(5):540–6.

Article  PubMed  PubMed Central  Google Scholar 

Walter S, Glymour MM, Koenen K, Liang L, Tchetgen Tchetgen EJ, Cornelis M, et al. Do genetic risk scores for body mass index predict risk of phobic anxiety? Evidence for a shared genetic risk factor. Psychol Med. 2015;45(1):181–91.

Article  PubMed  Google Scholar 

Hartwig FP, Davies NM, Hemani G, Davey SG. Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique. Int J Epidemiol. 2016;45(6):1717–26.

Article  PubMed  Google Scholar 

Zhao SS, Bowes J, Barton A, Davey Smith G, Richardson T. Separating the effects of childhood and adult body size on inflammatory arthritis: a Mendelian randomisation study. RMD Open. 2022;8(2):e002321.