Gorgoulis, V. et al. Cellular senescence: defining a path forward. Cell 179, 813–827 (2019).
Article CAS PubMed Google Scholar
Hayflick, L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37, 614–636 (1965).
Article CAS PubMed Google Scholar
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D. & Lowe, S. W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593–602 (1997).
Article CAS PubMed Google Scholar
Demaria, M. et al. Cellular senescence promotes adverse effects of chemotherapy and cancer relapse. Cancer Discov. 7, 165–176 (2017).
Article CAS PubMed Google Scholar
Schmitt, C. A., Wang, B. & Demaria, M. Senescence and cancer — role and therapeutic opportunities. Nat. Rev. Clin. Oncol. 19, 619–636 (2022).
Article PubMed PubMed Central Google Scholar
Wiley, C. D. et al. Mitochondrial dysfunction induces senescence with a distinct secretory phenotype. Cell Metab. 23, 303–314 (2016).
Article CAS PubMed Google Scholar
Faust, H. J. et al. IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis. J. Clin. Investig. 130, 5493–5507 (2020).
Article CAS PubMed PubMed Central Google Scholar
Hernandez-Segura, A., Nehme, J. & Demaria, M. Hallmarks of cellular senescence. Trends Cell Biol. 28, 436–453 (2018).
Article CAS PubMed Google Scholar
Freund, A., Laberge, R.-M., Demaria, M. & Campisi, J. Lamin B1 loss is a senescence-associated biomarker. Mol. Biol. Cell 23, 2066–2075 (2012).
Article CAS PubMed PubMed Central Google Scholar
Narita, M. et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113, 703–716 (2003).
Article CAS PubMed Google Scholar
Kohli, J. et al. Algorithmic assessment of cellular senescence in experimental and clinical specimens. Nat. Protoc. 16, 2471–2498 (2021).
Article CAS PubMed PubMed Central Google Scholar
Chang, J. et al. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nat. Med. 22, 78–83 (2016).
Article CAS PubMed Google Scholar
Krtolica, A., Parrinello, S., Lockett, S., Desprez, P.-Y. & Campisi, J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc. Natl Acad. Sci. USA 98, 12072–12077 (2001).
Article CAS PubMed PubMed Central Google Scholar
Coppé, J.-P. et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 6, e301 (2008).
Article PubMed PubMed Central Google Scholar
Acosta, J. C. et al. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 133, 1006–1018 (2008).
Article CAS PubMed Google Scholar
Kuilman, T. et al. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 133, 1019–1031 (2008).
Article CAS PubMed Google Scholar
Kuilman, T. & Peeper, D. S. Senescence-messaging secretome: SMS-ing cellular stress. Nat. Rev. Cancer 9, 81–94 (2009).
Article CAS PubMed Google Scholar
Mosteiro, L. et al. Tissue damage and senescence provide critical signals for cellular reprogramming in vivo. Science 354, eaaf4445 (2016).
Glück, S. et al. Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence. Nat. Cell Biol. 19, 1061–1070 (2017).
Article PubMed PubMed Central Google Scholar
Wang, B. et al. Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity. EMBO J. 41, e108946 (2022).
Article CAS PubMed PubMed Central Google Scholar
Hernandez-Segura, A. et al. Unmasking transcriptional heterogeneity in senescent cells. Curr. Biol. 27, 2652–2660.e4 (2017).
Article CAS PubMed PubMed Central Google Scholar
Basisty, N. et al. A proteomic atlas of senescence-associated secretomes for aging biomarker development. PLoS Biol. 18, e3000599 (2020).
Article PubMed PubMed Central Google Scholar
Wiley, C. D. et al. Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis. Cell Metab. 33, 1124–1136.e5 (2021).
Article CAS PubMed PubMed Central Google Scholar
Takasugi, M. et al. Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2. Nat. Commun. 8, 15729 (2017).
Article CAS PubMed PubMed Central Google Scholar
Borghesan, M. et al. Small extracellular vesicles are key regulators of non-cell autonomous intercellular communication in senescence via the interferon protein IFITM3. Cell Rep. 27, 3956–3971.e6 (2019).
Article CAS PubMed PubMed Central Google Scholar
Sagini, K. et al. Oncogenic H-Ras expression induces fatty acid profile changes in human fibroblasts and extracellular vesicles. Int. J. Mol. Sci. 19, 3515 (2018).
Article PubMed PubMed Central Google Scholar
Weiner-Gorzel, K. et al. Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells. Cancer Med. 4, 745–758 (2015).
Article CAS PubMed PubMed Central Google Scholar
Orjalo, A. V., Bhaumik, D., Gengler, B. K., Scott, G. K. & Campisi, J. Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network. Proc. Natl Acad. Sci. USA 106, 17031–17036 (2009).
Article CAS PubMed PubMed Central Google Scholar
Nakamura, Y., Aihara, R., Iwata, H., Kuwayama, T. & Shirasuna, K. IL1B triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via CCL2. Am. J. Reprod. Immunol. 85, e13365 (2021).
Article CAS PubMed Google Scholar
Ortiz-Montero, P., Londoño-Vallejo, A. & Vernot, J.-P. Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line. Cell Commun. Signal 15, 17 (2017).
Article PubMed PubMed Central Google Scholar
Wiggins, K. A. et al. IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype. Aging Cell 18, e12946 (2019).
Article PubMed PubMed Central Google Scholar
McCarthy, D. A., Clark, R. R., Bartling, T. R., Trebak, M. & Melendez, J. A. Redox control of the senescence regulator interleukin-1α and the secretory phenotype. J. Biol. Chem. 288, 32149–32159 (2013).
Article CAS PubMed PubMed Central Google Scholar
Mandinova, A. et al. S100A13 mediates the copper-dependent stress-induced release of IL-1α from both human U937 and murine NIH 3T3 cells. J. Cell Sci. 116, 2687–2696 (2003).
Article CAS PubMed Google Scholar
Su, Y. et al. S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α. Aging 11, 549–572 (2019).
Article CAS PubMed PubMed Central Google Scholar
Bhaumik, D. et al. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging 1, 402–411 (2009).
Article CAS PubMed PubMed Central Google Scholar
Wang, A.-P. et al. Pulmonary artery smooth muscle cell senescence promotes the proliferation of PASMCs by paracrine IL-6 in hypoxia-induced pulmonary hypertension. Front. Physiol. 12, 656139 (2021).
留言 (0)