Regulation of cellular and systemic sphingolipid homeostasis

Thudichum, J. L. W. A Treatise on the Chemical Constitution of the Brain (Archon Books, 1962).

Carter, H. E. & Humiston, C. G. Biochemistry of the sphingolipides. V. The structure of sphingine. J. Biol. Chem. 191, 727–733 (1951).

Article  CAS  PubMed  Google Scholar 

Klenk, E. Contribution to the concept of gangliosides [German]. Hoppe Seylers Z. Physiol. Chem. 288, 216–220 (1951).

CAS  PubMed  Google Scholar 

Brady, R. O. The sphingolipidoses. N. Engl. J. Med. 275, 312–318 (1966).

Article  CAS  PubMed  Google Scholar 

Stoffel, W. Sphingolipids. Annu. Rev. Biochem. 40, 57–82 (1971).

Article  CAS  PubMed  Google Scholar 

Hannun, Y. A. & Bell, R. M. Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses. Science 235, 670–674 (1987).

Article  CAS  PubMed  Google Scholar 

Kolesnick, R. N. 1,2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells. J. Biol. Chem. 262, 16759–16762 (1987).

Article  CAS  PubMed  Google Scholar 

Obeid, L. M., Linardic, C. M., Karolak, L. A. & Hannun, Y. A. Programmed cell death induced by ceramide. Science 259, 1769–1771 (1993).

Article  CAS  PubMed  Google Scholar 

Ghosh, T. K., Bian, J. & Gill, D. L. Intracellular calcium release mediated by sphingosine derivatives generated in cells. Science 248, 1653–1656 (1990).

Article  CAS  PubMed  Google Scholar 

Olivera, A. & Spiegel, S. Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature 365, 557–560 (1993).

Article  CAS  PubMed  Google Scholar 

Choi, O. H., Kim, J. H. & Kinet, J. P. Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor. Nature 380, 634–636 (1996).

Article  CAS  PubMed  Google Scholar 

Hla, T. & Maciag, T. An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors. J. Biol. Chem. 265, 9308–9313 (1990).

Article  CAS  PubMed  Google Scholar 

Lee, M. J. et al. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science 279, 1552–1555 (1998).

Article  CAS  PubMed  Google Scholar 

Hla, T., Lee, M. J., Ancellin, N., Paik, J. H. & Kluk, M. J. Lysophospholipids–receptor revelations. Science 294, 1875–1878 (2001).

Article  CAS  PubMed  Google Scholar 

Brinkmann, V. et al. Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat. Rev. Drug Discov. 9, 883–897 (2010).

Article  CAS  PubMed  Google Scholar 

Hojjati, M. R., Li, Z. & Jiang, X. C. Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in mice. Biochim. Biophys. Acta 1737, 44–51 (2005).

Article  CAS  PubMed  Google Scholar 

Buede, R., Rinker-Schaffer, C., Pinto, W. J., Lester, R. L. & Dickson, R. C. Cloning and characterization of LCB1, a Saccharomyces gene required for biosynthesis of the long-chain base component of sphingolipids. J. Bacteriol. 173, 4325–4332 (1991).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park, W. J. & Park, J. W. The role of sphingolipids in endoplasmic reticulum stress. FEBS Lett. 594, 3632–3651 (2020).

Article  CAS  PubMed  Google Scholar 

Hernandez-Corbacho, M. J., Salama, M. F., Canals, D., Senkal, C. E. & Obeid, L. M. Sphingolipids in mitochondria. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1862, 56–68 (2017).

Article  CAS  PubMed  Google Scholar 

Dunn, T. M., Tifft, C. J. & Proia, R. L. A perilous path: the inborn errors of sphingolipid metabolism. J. Lipid Res. 60, 475–483 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mandon, E. C., Ehses, I., Rother, J., van Echten, G. & Sandhoff, K. Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver. J. Biol. Chem. 267, 11144–11148 (1992).

Article  CAS  PubMed  Google Scholar 

Brady, R. O. & Koval, G. J. The enzymatic synthesis of sphingosine. J. Biol. Chem. 233, 26–31 (1958).

Article  CAS  PubMed  Google Scholar 

Brady, R. O., Formica, J. V. & Koval, G. J. The enzymatic synthesis of sphingosine. II. Further studies on the mechanism of the reaction. J. Biol. Chem. 233, 1072–1076 (1958).

Article  CAS  PubMed  Google Scholar 

Weiss, B. & Stoffel, W. Human and murine serine-palmitoyl-CoA transferase — cloning, expression and characterization of the key enzyme in sphingolipid synthesis. Eur. J. Biochem. 249, 239–247 (1997).

Article  CAS  PubMed  Google Scholar 

Hornemann, T., Richard, S., Rutti, M. F., Wei, Y. & von Eckardstein, A. Cloning and initial characterization of a new subunit for mammalian serine-palmitoyltransferase. J. Biol. Chem. 281, 37275–37281 (2006).

Article  CAS  PubMed  Google Scholar 

Han, G. et al. Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities. Proc. Natl Acad. Sci. USA 106, 8186–8191 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mandon, E. C., van Echten, G., Birk, R., Schmidt, R. R. & Sandhoff, K. Sphingolipid biosynthesis in cultured neurons. Down-regulation of serine palmitoyltransferase by sphingoid bases. Eur. J. Biochem. 198, 667–674 (1991).

Article  CAS  PubMed  Google Scholar 

Davis, D. L., Gable, K., Suemitsu, J., Dunn, T. M. & Wattenberg, B. W. The ORMDL/Orm-serine palmitoyltransferase (SPT) complex is directly regulated by ceramide: reconstitution of SPT regulation in isolated membranes. J. Biol. Chem. 294, 5146–5156 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Breslow, D. K. et al. Orm family proteins mediate sphingolipid homeostasis. Nature 463, 1048–1053 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mohassel, P. et al. Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis. Nat. Med. 27, 1197–1204 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Srivastava, S. et al. SPTSSA variants alter sphingolipid synthesis and cause a complex hereditary spastic paraplegia. Brain 146, 1420–1435 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Lone, M. A. et al. SPTLC1 variants associated with ALS produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins. J. Clin. Invest. 132, e161908 (2022).

留言 (0)

沒有登入
gif