Ajoolabady A, Aslkhodapasandhokmabad H, Zhou Y et al (2022) Epigenetic modification in alcohol-related liver diseases. Med Res Rev 42(4):1463–1491

Article  CAS  PubMed  Google Scholar 

Al Saihati HA, Badr OA, Dessouky AA et al (2024) Exploring the cytoprotective role of mesenchymal stem cell-derived exosomes in chronic liver fibrosis: Insights into the Nrf2/Keap1/p62 signaling pathway. Int Immunopharmacol 141:112934

Article  CAS  PubMed  Google Scholar 

Ani K, Marina S, Norah T et al (2022) Health disparities in chronic liver disease. Hepatology (Baltimore, Md) 77(4):1382–1403

Google Scholar 

Bian S, Zhao Y, Li F et al (2019) 20(S)-ginsenoside Rg3 promotes HeLa cell apoptosis by regulating autophagy. Molecules 24(20):3655

Article  CAS  PubMed  PubMed Central  Google Scholar 

Borkham-Kamphorst E, Van de Leur E, Haas U et al (2019) Liver parenchymal cells lacking Lipocalin 2 (LCN2) are prone to endoplasmic reticulum stress and unfolded protein response. Cell Signal 55:90–99

Article  CAS  PubMed  Google Scholar 

Chandel NS, Schumacker PT, Arch RH (2001) Reactive oxygen species are downstream products of TRAF-mediated signal transduction. J Biol Chem 276(46):42728–42736

Article  CAS  PubMed  Google Scholar 

Chen XJ, Liu WJ, Wen ML et al (2017) Ameliorative effects of compound K and ginsenoside Rh1 on nonalcoholic fatty liver disease in rats. Sci Rep 7(1):41144

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chieli E, Malvaldi G (1984) Role of the microsomal fad-containing monooxygenase in the liver toxicity of thioacetamide s-oxide. Toxicology 31:41–52

Article  CAS  PubMed  Google Scholar 

Chilakapati J, Shankar K, Korrapati MC et al (2005) Saturation toxicokinetics of thioacetamide: role in initiation of liver injury. Drug Metab Dispos 33(12):1877–1885

CAS  PubMed  Google Scholar 

Christensen LP (2009) Ginsenosides chemistry, biosynthesis, analysis, and potential health effects. AdvFood Nutr Res 55:1–99

CAS  Google Scholar 

Chung KW (2017) The critical role played by endotoxin-induced liver autophagy in the maintenance of lipid metabolism during sepsis. Autophagy 13:1113–1129

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cohen SM, Bevan C, Gollapudi B et al (2023) Evaluation of the carcinogenicity of carbon tetrachloride[J]. J Toxicol Environ Health B Crit Rev 26(6):342–370

Article  CAS  PubMed  Google Scholar 

Cui F, Blach S, Manzengo Mingiedi C et al (2023) Global reporting of progress toward elimination of hepatitis B and hepatitis C. Lancet Gastroenterol Hepatol 8(4):332–342

Article  CAS  PubMed  Google Scholar 

Ding C, Peng X, Yang J et al (2023) Rg3-loaded P407/CS/HA hydrogel inhibits UVB-induced oxidative stress, inflammation and apoptosis in HaCaT cells. Biomed Pharmacother 165:115177

Article  CAS  PubMed  Google Scholar 

Dong Y, Wang X, Xu L et al (2023) Development of a chimeric protein BiPPB-mIFNγ-tTβRII for improving the anti-fibrotic activity in vivo by targeting fibrotic liver and dual inhibiting the TGF-β1/Smad signaling pathway. Protein J 42(6):753–765

Article  CAS  PubMed  Google Scholar 

Drew L (2018) Liver cirrhosis: scar wars. Nature 564(7736):S73

Article  CAS  PubMed  Google Scholar 

Fan W, Adebowale K, Váncza L et al (2024) Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver. Nature 626(7999):635–642

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang J, Ji Q, Gao S et al (2022) PDGF-BB is involved in HIF-1α/CXCR4/CXCR7 axis promoting capillarization of hepatic sinusoidal endothelial cells. Heliyon 9(1):e12715

Article  PubMed  PubMed Central  Google Scholar 

Feng G, Valenti L, Wong VW et al (2024) Recompensation in cirrhosis: unraveling the evolving natural history of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol 21(1):46–56

Article  PubMed  Google Scholar 

Galaski J, Weiler-Normann C, Schakat M et al (2021) Update of the simplified criteria for autoimmune hepatitis: Evaluation of the methodology for immunoserological testing. J Hepatol 74(2):312–320

Article  CAS  PubMed  Google Scholar 

Gao Y, Yan J, Li J et al (2021) Ginsenoside Rg3 ameliorates acetaminophen-induced hepatotoxicity by suppressing inflammation and oxidative stress. J Pharm Pharmacol 73(3):322–331

Article  PubMed  Google Scholar 

Geng J, Fu W, Yu X et al (2020) Ginsenoside Rg3 alleviates ox-LDL induced endothelial dysfunction and prevents atherosclerosis in ApoE-/-mice by regulating PPARγ/FAK signaling pathway. Front Pharmacol 11:500

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gepner Y, Shelef I, Schwarzfuchs D et al (2018) Effect of distinct lifestyle interventions on mobilization of fat storage pools: CENTRAL magnetic resonance imaging randomized controlled trial. Circulation 137(11):1143–1157

Article  PubMed  Google Scholar 

Guengerich FP (2020) Cytochrome P450 2E1 and its roles in disease. Chem Biol Interact 322:109056

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gum SI, Cho MK (2013) The amelioration of N-acetyl-p-benzoquinone imine toxicity by ginsenoside Rg3: the role of Nrf2-mediated detoxification and Mrp1/Mrp3 transports. Oxid Med Cell Longev 2013:957947

Article  PubMed  PubMed Central  Google Scholar 

Guo YF, Li X, Chi L (2016) Research progress of anti-liver fibrosis effect of traditional Chinese medicine monomer. Glob Chin Med 9(9):4

Google Scholar 

Hamberger F, Mederacke YS, Mederacke I (2023) An inducible model for genetic manipulation and fate-tracing of PDGFRβ-expressing fibrogenic cells in the liver. Sci Rep 13(1):7322

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hancu A, Mihai MC, Axelerad AD (2011) Wilson’s disease: a challenging diagnosis. Rev Med Chir Soc Med Nat Iasi 115(1):58–63

PubMed  Google Scholar 

He S, Tian S, He X et al (2021) Multiple targeted self-emulsifying compound RGO reveals obvious anti-tumor potential in hepatocellular carcinoma. Mol Ther Oncolytics 22:604–616

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heeok H, Delgerzul B, Gu SH (2021) Anticancer activities of ginsenosides, the main active components of ginseng. Evid-Based Complement Altern Med 2021:8858006

Google Scholar 

Helms S (2004) Cancer prevention and therapeutics: Panax ginseng, Alternative medicine review. J Clin Therapeut 9(3):259–274

Google Scholar 

Hernandez-Gea V (2012) Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. Gastroenterology 142:938–946

Article  PubMed  Google Scholar 

Hou YL, Tsai YH, Lin YH et al (2014) Ginseng extract and ginsenoside Rb1 attenuate carbon tetrachloride-induced liver fibrosis in rats. BMC Complement. Altern Med 14(1):415

Article  PubMed  PubMed Central  Google Scholar 

Hu Y, Lang Z, Li X et al (2024) Ginsenoside Rg3 promotes hepatic stellate cell ferroptosis by epigenetically regulating ACSL4 to suppress liver fibrosis progression[J]. Phytomedicine 124:155289

Article  CAS  PubMed