Haloperidol for Treatment of ICU Delirium — Progress or Setback?

Delirium is common, morbid, and costly in hospitalized older adults and in adults of all ages in the intensive care unit (ICU).1 Multifactorial nonpharmacologic interventions can prevent delirium, but there are no approved treatments.1,2 In 2018, the investigators of the large Modifying the Impact of ICU-Associated Neurological Dysfunction–USA (MIND-USA) trial concluded that antipsychotic agents were not effective for treatment of delirium,3 and in 2019, two systematic reviews commissioned by the Agency for Healthcare Research and Quality concluded that antipsychotics were not effective for treatment or prevention.4,5 However, these studies did not rule out targeted use of antipsychotics for behaviors that . . .

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