Two Steps Forward, One Step Back

Tuberculosis is an important cause of death worldwide, and drug resistance is implicated in one third of the almost 2 million deaths from tuberculosis each year.1 Previous regimens for drug-resistant tuberculosis took 18 to 24 months to complete. Patients disliked painful and inconvenient daily injections, and caregivers expressed despair about trying to enforce adherence to toxic and ineffective regimens. In time, revised guidelines allowed selected patients to receive treatment for only 9 months, but daily injections and poor overall success remained.1 Progress accelerated with the Food and Drug Administration approval in 2012 of bedaquiline, the first new antituberculosis agent in . . .

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