The perplexing role of RAGE in pulmonary fibrosis: causality or casualty?

1. Kim, DS, Collard, HR, King, TE. Classification and natural history of the idiopathic interstitial pneumonias. Proc Am Thorac Soc 2006; 3: 285–292.
Google Scholar | Crossref | Medline2. Wolters, PJ, Collard, HR, Jones, KD. Pathogenesis of idiopathic pulmonary fibrosis. Annu Rev Pathol 2014; 9: 157–179.
Google Scholar | Crossref | Medline | ISI3. Wilson, MS, Wynn, TA. Pulmonary fibrosis: pathogenesis, etiology and regulation. Mucosal Immunol 2009; 2: 103–121.
Google Scholar | Crossref | Medline | ISI4. Saito, S, Alkhatib, A, Kolls, JK, et al Pharmacotherapy and adjunctive treatment for idiopathic pulmonary fibrosis (IPF). J Thorac Dis 2019; 11: S1740–S1754.
Google Scholar | Crossref | Medline5. Behr, J, Prasse, A, Wirtz, H, et al Survival and course of lung function in the presence or absence of antifibrotic treatment in patients with idiopathic pulmonary fibrosis: long-term results of the INSIGHTS-IPF registry. Eur Respir J 2020; 56: 1902279.
Google Scholar | Crossref | Medline6. Eming, SA, Martin, P, Tomic-Canic, M. Wound repair and regeneration: mechanisms, signaling, and translation. Sci Transl Med 2014; 6: 265sr6.
Google Scholar | Crossref | Medline7. Wynn, TA. Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest 2007; 117: 524–529.
Google Scholar | Crossref | Medline | ISI8. Wynn, TA. Integrating mechanisms of pulmonary fibrosis. J Exp Med 2011; 208: 1339–1350.
Google Scholar | Crossref | Medline | ISI9. Wynn, TA, Vannella, KM. Macrophages in tissue repair, regeneration, and fibrosis. Immunity 2016; 44: 450–462.
Google Scholar | Crossref | Medline | ISI10. Wynn, TA, Ramalingam, TR. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med 2012; 18: 1028–1040.
Google Scholar | Crossref | Medline | ISI11. Snijder, J, Peraza, J, Padilla, M, et al Pulmonary fibrosis: a disease of alveolar collapse and collagen deposition. Expert Rev Respir Med 2019; 13: 615–619.
Google Scholar | Crossref | Medline12. Gieseck, RL, Wilson, MS, Wynn, TA. Type 2 immunity in tissue repair and fibrosis. Nat Rev Immunol 2018; 18: 62–76.
Google Scholar | Crossref | Medline13. Galli, SJ, Borregaard, N, Wynn, TA. Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat Immunol 2011; 12: 1035–1044.
Google Scholar | Crossref | Medline | ISI14. Neeper, M, Schmidt, AM, Brett, J, et al Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J Biol Chem 1992; 267: 14998–15004.
Google Scholar | Crossref | Medline | ISI15. Brett, J, Schmidt, AM, Yan, SD, et al Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues. Am J Pathol 1993; 143: 1699–1712.
Google Scholar | Medline | ISI16. Hanford, LE, Fattman, CL, Shaefer, LM, et al Regulation of receptor for advanced glycation end products during bleomycin-induced lung injury. Am J Respir Cell Mol Biol 2003; 29: S77–S81.
Google Scholar | Medline17. Oczypok, EA, Perkins, TN, Oury, TD. All the “RAGE” in lung disease: the receptor for advanced glycation endproducts (RAGE) is a major mediator of pulmonary inflammatory responses. Paediatr Respir Rev 2017; 23: 40–49.
Google Scholar | Medline18. Hudson, BI, Carter, AM, Harja, E, et al Identification, classification, and expression of RAGE gene splice variants. FASEB J 2008; 22: 1572–1580.
Google Scholar | Crossref | Medline19. Kalea, AZ, Reiniger, N, Yang, H, et al Alternative splicing of the murine receptor for advanced glycation end-products (RAGE) gene. FASEB J 2009; 23: 1766–1774.
Google Scholar | Crossref | Medline20. Hanford, LE, Enghild, JJ, Valnickova, Z, et al Purification and characterization of mouse soluble receptor for advanced glycation end products (sRAGE). J Biol Chem 2004; 279: 50019–50024.
Google Scholar | Crossref | Medline | ISI21. Malherbe, P, Richards, JG, Gaillard, H, et al CDNA cloning of a novel secreted isoform of the human receptor for advanced glycation end products and characterization of cells co-expressing cell-surface scavenger receptors and Swedish mutant amyloid precursor protein. Brain Res Mol Brain Res 1999; 71: 159–170.
Google Scholar | Crossref | Medline22. Yonekura, H, Yamamoto, Y, Sakurai, S, et al Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury. Biochem J 2003; 370: 1097–1109.
Google Scholar | Crossref | Medline | ISI23. Zhang, L, Bukulin, M, Kojro, E, et al Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases. J Biol Chem 2008; 283: 35507–35516.
Google Scholar | Crossref | Medline | ISI24. Lopez-Diez, R, Shekhtman, A, Ramasamy, R, et al Cellular mechanisms and consequences of glycation in atherosclerosis and obesity. Biochim Biophys Acta 2016; 1862: 2244–2252.
Google Scholar | Crossref | Medline25. Tobon-Velasco, JC, Cuevas, E, Torres-Ramos, MA. Receptor for AGEs (RAGE) as mediator of NF-kB pathway activation in neuroinflammation and oxidative stress. CNS Neurol Disord Drug Targets 2014; 13: 1615–1626.
Google Scholar | Crossref | Medline26. Li, J, Schmidt, AM. Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation end products. J Biol Chem 1997; 272: 16498–16506.
Google Scholar | Crossref | Medline | ISI27. Hudson, BI, Kalea, AZ, Del Mar Arriero, M, et al Interaction of the RAGE cytoplasmic domain with diaphanous-1 is required for ligand-stimulated cellular migration through activation of Rac1 and Cdc42. J Biol Chem 2008; 283: 34457–34468.
Google Scholar | Crossref | Medline | ISI28. Brizzi, MF, Dentelli, P, Rosso, A, et al RAGE- and TGF-beta receptor-mediated signals converge on STAT5 and p21waf to control cell-cycle progression of mesangial cells: a possible role in the development and progression of diabetic nephropathy. FASEB J 2004; 18: 1249–1251.
Google Scholar | Crossref | Medline29. Fukami, K, Ueda, S, Yamagishi, S, et al AGEs activate mesangial TGF-beta-Smad signaling via an angiotensin II type I receptor interaction. Kidney Int 2004; 66: 2137–2147.
Google Scholar | Crossref | Medline | ISI30. Englert, JM, Hanford, LE, Kaminski, N, et al A role for the receptor for advanced glycation end products in idiopathic pulmonary fibrosis. Am J Pathol 2008; 172: 583–591.
Google Scholar | Crossref | Medline31. Ramsgaard, L, Englert, JM, Tobolewski, J, et al The role of the receptor for advanced glycation end-products in a murine model of silicosis. PLoS One 2010; 5: e9604.
Google Scholar | Crossref | Medline32. Queisser, MA, Kouri, FM, Konigshoff, M, et al Loss of RAGE in pulmonary fibrosis: molecular relations to functional changes in pulmonary cell types. Am J Respir Cell Mol Biol 2008; 39: 337–345.
Google Scholar | Crossref | Medline33. Selman, M, Carrillo, G, Estrada, A, et al Accelerated variant of idiopathic pulmonary fibrosis: clinical behavior and gene expression pattern. PLoS One 2007; 2: e482.
Google Scholar | Crossref | Medline34. Konishi, K, Gibson, KF, Lindell, KO, et al Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2009; 180: 167–175.
Google Scholar | Crossref | Medline | ISI35. Ohlmeier, S, Mazur, W, Salmenkivi, K, et al Proteomic studies on receptor for advanced glycation end product variants in idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Proteomics Clin Appl 2010; 4: 97–105.
Google Scholar | Crossref | Medline36. Fehrenbach, H, Kasper, M, Tschernig, T, et al Receptor for advanced glycation endproducts (RAGE) exhibits highly differential cellular and subcellular localisation in rat and human lung. Cell Mol Biol (Noisy-le-grand) 1998; 44: 1147–1157.
Google Scholar | Medline | ISI37. Perkins, TN, Oczypok, EA, Dutz, RE, et al The receptor for advanced glycation endproducts is a critical mediator of type 2 cytokine signaling in the lungs. J Allergy Clin Immunol 2019; 144: 796–808.e12.
Google Scholar | Crossref | Medline38. Di Candia, L, Gomez, E, Venereau, E, et al HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4. J Allergy Clin Immunol 2017; 140: 584–587.e8.
Google Scholar | Crossref | Medline39. Van Zoelen, MA, Wieland, CW, van der Windt, GJ, et al Receptor for advanced glycation end products is protective during murine tuberculosis. Mol Immunol 2012; 52: 183–189.
Google Scholar | Crossref | Medline40. Wang, CH, Punde, TH, Huang, C-D, et al Fibrocyte trafficking in patients with chronic obstructive asthma and during an acute asthma exacerbation. J Allergy Clin Immunol 2015; 135: 1154–1162.e1–e5.
Google Scholar | Crossref | Medline41. Robinson, AB, Johnson, KD, Bennion, BG, et al RAGE signaling by alveolar macrophages influences tobacco smoke-induced inflammation. Am J Physiol Lung Cell Mol Physiol 2012; 302: L1192–L1199.
Google Scholar | Crossref | Medline42. Huebener, P, Pradere, JP, Hernandez, C, et al The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis. J Clin Invest 2019; 130: 1802.
Google Scholar43. Inghilleri, S, Morbini, P, Campo, I, et al Factors influencing oxidative imbalance in pulmonary fibrosis: an immunohistochemical study. Pulm Med 2011; 2011: 421409.
Google Scholar | Medline44. Morbini, P, Villa, C, Campo, I, et al The receptor for advanced glycation end products and its ligands: a new inflammatory pathway in lung disease? Mod Pathol 2006; 19: 1437–1445.
Google Scholar | Crossref | Medline45. Xu, X, Chen, H, Zhu, X, et al S100A9 promotes human lung fibroblast cells activation through receptor for advanced glycation end-product-mediated extracellular-regulated kinase 1/2, mitogen-activated protein-kinase and nuclear factor-kappaB-dependent pathways. Clin Exp Immunol 2013; 173: 523–535.
Google Scholar | Crossref | Medline46. Bargagli, E, Penza, F, Bianchi, N, et al Controversial role of RAGE in the pathogenesis of idiopathic pulmonary fibrosis. Respir Physiol Neurobiol 2009; 165: 119–120; author reply 21–22.
Google Scholar | Crossref | Medline47. Rosas, IO, Richards, TJ, Konishi, K, et al MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis. PLoS Med 2008; 5: e93.
Google Scholar | Crossref | Medline | ISI48. Repapi, E, Sayers, I, Wain, LV,

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