DSP rs2076295 variants influence nintedanib and pirfenidone outcomes in idiopathic pulmonary fibrosis: a pilot study

1. Raghu, G, Remy-Jardin, M, Myers, JL, et al Diagnosis of idiopathic pulmonary fibrosis. An official ATS/ERS/JRS/ALAT clinical practice guideline. Am J Respir Crit Care Med 2018; 198: e44–e68.
Google Scholar | Crossref | Medline2. Kaur, A, Mathai, S, Schwartz, DA. Genetics in idiopathic pulmonary fibrosis pathogenesis, prognosis, and treatment. Front Med 2017; 4: 154.
Google Scholar | Crossref3. Schwartz, DA. Idiopathic pulmonary fibrosis is a complex genetic disorder. Trans Am Clin Climatol Assoc 2016; 127: 34–45.
Google Scholar | Medline4. Mathai, SK, Newton, CA, Schwartz, DA, et al Pulmonary fibrosis in the era of stratified medicine. Thorax 2016; 71: 1154–1160.
Google Scholar | Crossref | Medline5. Oldham, JM, Ma, SF, Martinez, FJ, et al TOLLIP, MUC5B, and the response to N-acetylcysteine among individuals with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2015; 192: 1475–1482.
Google Scholar | Crossref | Medline6. Kropski, JA, Young, LR, Cogan, JD, et al Genetic evaluation and testing of patients and families with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2016; 195: 1423–1428.
Google Scholar | Crossref7. Fingerlin, TE, Murphy, E, Zhang, W, et al Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet 2013; 45: 613–620.
Google Scholar | Crossref | Medline | ISI8. Seibold, MA, Wise, AL, Speer, MC, et al A common MUC5B promoter polymorphism and pulmonary fibrosis. N Engl J Med 2011; 364: 1503–1512.
Google Scholar | Crossref | Medline9. Nakano, Y, Yang, IV, Walts, AD, et al MUC5B promoter variant rs35705950 affects MUC5B expression in the distal airways in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2016; 193: 464–466.
Google Scholar | Crossref | Medline10. Mathai, S, Pedersen, BS, Smith, K, et al Desmoplakin variants are associated with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2016; 193: 1151–1160.
Google Scholar | Crossref | Medline11. Allen, RJ, Porte, J, Braybrooke, R, et al Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study. Lancet Respir Med 2017; 5: 869–880.
Google Scholar | Crossref | Medline12. Raghu, G, Rochwerg, B, Zhang, Y, et al An official ATS/ERS/JRS/ALAT clinical practice guideline: treatment of idiopathic pulmonary fibrosis: executive summary. An update of the 2011 clinical practice guideline. Am J Respir Crit Care Med 2015; 192: 238–248.
Google Scholar | Crossref13. Zurkova, M, Kriegova, E, Kolek, V, et al Effect of pirfenidone on lung function decline and survival: 5-yr experience from a real-life IPF cohort from the Czech EMPIRE registry. Respir Res 2019; 20: 16.
Google Scholar | Crossref | Medline14. Doubková, M, Švancara, J, Svoboda, M, et al EMPIRE Registry, Czech part: impact of demographics, pulmonary function and HRCT on survival and clinical course in idiopathic pulmonary fibrosis. Clin Respir J 2018; 12: 1526–1535.
Google Scholar | Crossref | Medline15. Gay, SE, Kazerooni, EA, Toews, GB, et al Idiopathic pulmonary fibrosis: predicting response to therapy and survival. Am J Respir Crit Care Med 1998; 157: 1063–1072.
Google Scholar | Crossref | Medline | ISI16. Kocova, E, Vanasek, J, Koblizek, V, et al Scoring of the radiological picture of idiopathic interstitial pneumonia: a study to verify the reliability of the method. Acta Radiol Open 2015; 4: 2058460115605865.
Google Scholar | SAGE Journals | ISI17. Meyer, KC, Raghu, G, Baughma, RP, et al An official American Thoracic Society clinical practice guideline: the clinical utility of bronchoalveolar lavage cellular analysis in interstitial lung disease. Am J Respir Crit Care Med 2012; 185: 1004–1014.
Google Scholar | Crossref | Medline18. Obr, A, Procházka, V, Jirkuvová, A, et al TP53 Mutation and complex karyotype portends a dismal prognosis in patients with Mantle Cell Lymphoma. Clin Lymphoma Myeloma Leuk 2018; 18: 762–768.
Google Scholar | Crossref | Medline19. Petrackova, A, Vasinek, M, Sedlarikova, L, et al Standardization of sequencing coverage depth in NGS: recommendation for detection of clonal and subclonal mutations in cancer diagnostics. Front Oncol 2019; 9: 851.
Google Scholar | Crossref | Medline20. Rothman, KJ. No adjustments are needed for multiple comparisons. Epidemiology 1990; 1: 43–46.
Google Scholar | Crossref | Medline21. Gan, WH, Huang, K, Lv, ZW, et al Comparison of in-vitro anti-fibrotic effects of pirfenidone and nintedanib. Eur Respir J 2019; 54: PA1282.
Google Scholar22. Li, XH, Lv, ZW, Huang, K, et al Comparison of in-vivo anti-fibrotic effects of pirfenidone and nintedanib in bleomycin-induced pulmonary fibrosis model. Eur Respir J 2019; 54: PA5377.
Google Scholar23. Bonella, F, Stowasser, S, Wollin, L. Idiopathic pulmonary fibrosis: current treatment options and critical appraisal of nintedanib. Drug Des Devel Ther 2015; 9: 6407–6419.
Google Scholar | Medline24. Hilberg, F, Roth, GJ, Krssak, M, et al BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res 2008; 68: 4774–4782.
Google Scholar | Crossref | Medline | ISI25. Jin, J, Togo, S, Kadoya, K, et al Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1. Respir Res 2019; 20: 119.
Google Scholar | Crossref | Medline26. Noth, I, Zhang, Y, Ma, SF, et al Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. Lancet Respir Med 2013; 1: 309–317.
Google Scholar | Crossref | Medline27. Peljto, AL, Zhang, Y, Fingerlin, TE, et al Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis. JAMA 2013; 309: 2232–2239.
Google Scholar | Crossref | Medline28. Hambly, N, Shimbori, C, Kolb, M. Molecular classification of idiopathic pulmonary fibrosis. Respirology 2015; 20: 1010–1022.
Google Scholar | Crossref | Medline29. Zhang, Y, Noth, I, Garcia, JG, et al A variant in the promoter of MUC5B and idiopathic pulmonary fibrosis. N Engl J Med 2011; 364: 1576–1577.
Google Scholar | Crossref | Medline30. Seibold, MA, Smith, RW, Urbanek, C, et al The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium. PLoS One 2013; 8: e58658.
Google Scholar | Crossref | Medline31. Yang, IV, Fingerlin, TE, Evans, CM, et al MUC5B and idiopathic pulmonary fibrosis. Ann Am Thorac Soc 2015; 12(Suppl. 2): S193–S199.
Google Scholar | Medline32. Biondini, D, Cocconcelli, E, Bernardinello, N, et al Prognostic role of MUC5B rs3570590 genotype in patients with idiopathic pulmonary fibrosis (IPF) on antifibrotic treatment. Respir Res 2021; 22: 98.
Google Scholar | Crossref | Medline33. Bonella, F, Campo, I, Zorzetto, M, et al Potential clinical utility of MUC5B and TOLLIP single nucleotide polymorphisms (SNPs) in the management of patients with IPF. Orphanet J Rare Dis 2021; 16: 111.
Google Scholar | Crossref | Medline34. Lehmann, M, Buhl, L, Alsafadi, HN, et al Differential effects of nintedanib and pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis. Respir Res 2018; 19: 175.
Google Scholar | Crossref | Medline35. Kim, W, Cho, MH, Sakornsakolpat, P, et al DSP variants may be associated with longitudinal change in quantitative emphysema. Respir Res 2019; 20: 160.
Google Scholar | Crossref | Medline36. Mejía, M, Carrillo, G, Rojas-Serrano, J, et al Idiopathic pulmonary fibrosis and emphysema: decreased survival associated with severe pulmonary arterial hypertension. Chest 2009; 136: 10–15.
Google Scholar | Crossref | Medline | ISI37. Mitchell, PD, Das, JP, Murphy, DJ, et al Idiopathic pulmonary fibrosis with emphysema: evidence of synergy among emphysema and idiopathic pulmonary fibrosis in smokers. Respir Care 2015; 60: 259–268.
Google Scholar | Crossref | Medline38. Keller, CA, Naunheim, KS, Osterloh, J, et al Histopathologic diagnosis made in lung tissue resected from patients with severe emphysema undergoing lung volume reduction surgery. Chest 1997; 111: 941–947.
Google Scholar | Crossref | Medline39. Tran, T, Šterclová, M, Mogulkoc, N, et al The European MultiPartner IPF registry (EMPIRE): validating long-term prognostic factors in idiopathic pulmonary fibrosis. Respir Res 2020; 21: 11.
Google Scholar | Crossref | Medline

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