The Potential Utility of (2S,4R)-4-[18F]fluoroglutamine as a Novel Metabolic Imaging Marker for Inflammation Explored by Rat Models of Arthritis and Paw Edema

Xu X, Zhu H, Liu F et al (2020) Dynamic PET/CT imaging of 18F-(2S,4R)-4-Fluoroglutamine in healthy volunteers and oncological patients. Eur J Nucl Med Mol Imaging 47:2280–2292

Article  CAS  PubMed  Google Scholar 

Venneti S, Dunphy MP, Zhang H et al (2015) Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo. Sci Transl Med 7:274ra217

Article  Google Scholar 

Dunphy MPS, Harding JJ, Venneti S et al (2018) In vivo PET assay of tumor glutamine flux and metabolism: in-uman trial of 18F-(2S,4R)-4-Fluoroglutamine. Radiology 287:667–675

Article  PubMed  Google Scholar 

Cruzat V, Macedo Rogero M, Noel Keane K, Curi R, Newsholme P (2018) Glutamine: metabolism and mmune function, supplementation and clinical translation. Nutrients 10:1564

Article  PubMed  PubMed Central  Google Scholar 

Lopes AH, Silva RL, Fonseca MD et al (2020) Molecular basis of carrageenan-induced cytokines production in macrophages. Cell Commun Signal 18:141

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cunha TM, Verri WA Jr, Schivo IR et al (2008) Crucial role of neutrophils in the development of mechanical inflammatory hypernociception. J Leukoc Biol 83:824–832

Article  CAS  PubMed  Google Scholar 

Zarpelon AC, Cunha TM, Alves-Filho JC et al (2013) IL-33/ST2 signalling contributes to carrageenin-induced innate inflammation and inflammatory pain: role of cytokines, endothelin-1 and prostaglandin E2. Br J Pharmacol 169:90–101

Article  CAS  PubMed  PubMed Central  Google Scholar 

Trentham DE, Townes AS, Kang AH (1977) Autoimmunity to type II collagen an experimental model of arthritis. J Exp Med 146:857–868

Article  CAS  PubMed  Google Scholar 

Griffiths MM (1988) Immunogenetics of collagen-induced arthritis in rats. Int Rev Immunol 4:1–15

Article  CAS  PubMed  Google Scholar 

Brand DD, Latham KA, Rosloniec EF (2007) Collagen-induced arthritis. Nat Protoc 2:1269–1275

Article  CAS  PubMed  Google Scholar 

Zhang X, Basuli F, Shi ZD et al (2016) Automated synthesis of [(18)F](2S,4R)-4-fluoroglutamine on a GE TRACERlab™ FX-N pro module. Appl Radiat Isot 112:110–114

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qu W, Zha Z, Ploessl K et al (2011) Synthesis of optically pure 4-fluoro-glutamines as potential metabolic imaging agents for tumors. J Am Chem Soc 133:1122–1133

Article  CAS  PubMed  Google Scholar 

Otterness IG, Moore PF (1988) Carrageenan foot edema test. Methods Enzymol 162:320–327

Article  CAS  PubMed  Google Scholar 

Hayer S, Vervoordeldonk MJ, Denis MC et al (2021) SMASH’ recommendations for standardised microscopic arthritis scoring of histological sections from inflammatory arthritis animal models. Ann Rheum Dis 80:714–726

Article  CAS  PubMed  Google Scholar 

Raposo B, Vaartjes D, Ahlqvist E, Nandakumar KS, Holmdahl R (2015) System A amino acid transporters regulate glutamine uptake and attenuate antibody-mediated arthritis. Immunology 146:607–617

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takahashi S, Saegusa J, Sendo S et al (2017) Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther 19:76

Article  PubMed  PubMed Central  Google Scholar 

McNearney T, Baethge BA, Cao S, Alam R, Lisse JR, Westlund KN (2004) Excitatory amino acids, TNF-alpha, and chemokine levels in synovial fluids of patients with active arthropathies. Clin Exp Immunol 137:621–627

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sanchez-Lopez E, Cheng A, Guma M (2019) Can metabolic pathways be therapeutic targets in rheumatoid arthritis? J Clin Med 8:753

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ueda Y, Saegusa J, Okano T et al (2019) Additive effects of inhibiting both mTOR and glutamine metabolism on the arthritis in SKG mice. Sci Rep 9:6374

Article  PubMed  PubMed Central  Google Scholar 

Xu T, Stewart KM, Wang X et al (2017) Metabolic control of T(H)17 and induced T(reg) cell balance by an epigenetic mechanism. Nature 548:228–233

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu PS, Wang H, Li X et al (2017) α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming. Nat Immunol 18:985–994

Article  CAS  PubMed  Google Scholar 

Tannahill GM, Curtis AM, Adamik J et al (2013) Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature 496:238–242

Article  CAS  PubMed  PubMed Central  Google Scholar 

Palani S, Miner MWG, Virta J et al (2022) Exploiting glutamine consumption in atherosclerotic lesions by Positron Emission Tomography Tracer (2S,4R)-4-(18)F-Fluoroglutamine. Front Immunol 13:821423

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sadiku P, Willson JA, Ryan EM et al (2021) Neutrophils fuel effective Immune responses through Gluconeogenesis and Glycogenesis. Cell Metabol 33:411–423e414

Article  CAS  Google Scholar 

Zhang L, Yuan Y, Xu Q, Jiang Z, Chu C-Q (2019) Contribution of neutrophils in the pathogenesis of rheumatoid arthritis. J Biomed Res 34:86–93

Article  CAS  PubMed  Google Scholar 

Cooper AJ, Krasnikov BF, Pinto JT, Kung HF, Li J, Ploessl K (2012) Comparative enzymology of (2S,4R)4-fluoroglutamine and (2S,4R)4-fluoroglutamate. Comp Biochem Physiol B Biochem Mol Biol 163:108–120

Article  CAS  PubMed  PubMed Central  Google Scholar 

留言 (0)

沒有登入
gif