World Health Organization. Global Health Estimates.: https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death (2021). Accessed 13 November 2024.

Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, et al. 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119–77. https://doi.org/10.1093/eurheartj/ehx393.

Article  PubMed  Google Scholar 

Farb A, Burke AP, Tang AL, Liang TY, Mannan P, Smialek J, et al. Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary death. Circulation. 1996;93(7):1354–63. https://doi.org/10.1161/01.cir.93.7.1354.

Article  CAS  PubMed  Google Scholar 

van der Wal AC, Becker AE, van der Loos CM, Das PK. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation. 1994;89(1):36–44. https://doi.org/10.1161/01.cir.89.1.36.

Article  PubMed  Google Scholar 

Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20(5):1262–75. https://doi.org/10.1161/01.atv.20.5.1262.

Article  CAS  PubMed  Google Scholar 

Konishi T, Virmani R, Jinnouchi H, Kawai K, Sekimoto T, Kawakami R, et al. Plaque histological characteristics in individuals with sudden coronary death. Vascul Pharmacol. 2023;153:107240. https://doi.org/10.1016/j.vph.2023.107240.

Article  CAS  PubMed  Google Scholar 

Cornelissen A, Jinnouchi H, Sakamoto A, Torii S, Kuntz SH, Guo L, et al. Evaluation and management of the vulnerable plaque. Curr Cardiovasc Risk Rep. 2019;13:1–11.

Article  Google Scholar 

Dai J, Xing L, Jia H, Zhu Y, Zhang S, Hu S, et al. In vivo predictors of plaque erosion in patients with ST-segment elevation myocardial infarction: a clinical, angiographical, and intravascular optical coherence tomography study. Eur Heart J. 2018;39(22):2077–85. https://doi.org/10.1093/eurheartj/ehy101.

Article  PubMed  Google Scholar 

Fahed AC, Jang IK. Plaque erosion and acute coronary syndromes: phenotype, molecular characteristics and future directions. Nat Rev Cardiol. 2021;18(10):724–34. https://doi.org/10.1038/s41569-021-00542-3.

Article  PubMed  Google Scholar 

Kolodgie FD, Burke AP, Farb A, Weber DK, Kutys R, Wight TN, et al. Differential accumulation of proteoglycans and hyaluronan in culprit lesions: insights into plaque erosion. Arterioscler Thromb Vasc Biol. 2002;22(10):1642–8. https://doi.org/10.1161/01.atv.0000034021.92658.4c.

Article  CAS  PubMed  Google Scholar 

Virmani R, Burke AP, Farb A, Kolodgie FD. Pathology of the vulnerable plaque. J Am Coll Cardiol. 2006;47(8 Suppl):C13–8. https://doi.org/10.1016/j.jacc.2005.10.065.

Article  CAS  PubMed  Google Scholar 

Burke AP, Farb A, Malcom GT, Liang Y, Smialek J, Virmani R. Effect of risk factors on the mechanism of acute thrombosis and sudden coronary death in women. Circulation. 1998;97(21):2110–6. https://doi.org/10.1161/01.cir.97.21.2110.

Article  CAS  PubMed  Google Scholar 

Virmani R, Burke AP, Farb A, Kolodgie FD. Pathology of the unstable plaque. Prog Cardiovasc Dis. 2002;44(5):349–56. https://doi.org/10.1053/pcad.2002.122475.

Article  PubMed  Google Scholar 

Campbell IC, Suever JD, Timmins LH, Veneziani A, Vito RP, Virmani R, et al. Biomechanics and inflammation in atherosclerotic plaque erosion and plaque rupture: implications for cardiovascular events in women. PLoS ONE. 2014;9(11):e111785. https://doi.org/10.1371/journal.pone.0111785.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yahagi K, Zarpak R, Sakakura K, Otsuka F, Kutys R, Ladich E, et al. Multiple simultaneous plaque erosion in 3 coronary arteries. JACC Cardiovasc Imaging. 2014;7(11):1172–4. https://doi.org/10.1016/j.jcmg.2014.08.005.

Article  PubMed  Google Scholar 

Burke AP, Kolodgie FD, Farb A, Weber D, Virmani R. Morphological predictors of arterial remodeling in coronary atherosclerosis. Circulation. 2002;105(3):297–303. https://doi.org/10.1161/hc0302.102610.

Article  PubMed  Google Scholar 

Sato Y, Hatakeyama K, Yamashita A, Marutsuka K, Sumiyoshi A, Asada Y. Proportion of fibrin and platelets differs in thrombi on ruptured and eroded coronary atherosclerotic plaques in humans. Heart. 2005;91(4):526–30. https://doi.org/10.1136/hrt.2004.034058.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Konishi T, Kawai K, Kawakami R, Ghosh SKB, Vozenilek AE, Bellissard A, et al. Histologic Assessment of Thromboemboli due to Plaque rupture, Plaque Erosion, or COVID-19 Microthrombi. JACC Case Rep. 2023;14:101826. https://doi.org/10.1016/j.jaccas.2023.101826.

Article  PubMed  PubMed Central  Google Scholar 

Baaten C, Nagy M, Bergmeier W, Spronk HMH, van der Meijden PEJ. Platelet biology and function: plaque erosion vs. rupture. Eur Heart J. 2024;45(1):18–31. https://doi.org/10.1093/eurheartj/ehad720.

Article  CAS  PubMed  Google Scholar 

Schwartz RS, Burke A, Farb A, Kaye D, Lesser JR, Henry TD, et al. Microemboli and microvascular obstruction in acute coronary thrombosis and sudden coronary death: relation to epicardial plaque histopathology. J Am Coll Cardiol. 2009;54(23):2167–73. https://doi.org/10.1016/j.jacc.2009.07.042.

Article  PubMed  Google Scholar 

Kramer MC, Rittersma SZ, de Winter RJ, Ladich ER, Fowler DR, Liang YH, et al. Relationship of thrombus healing to underlying plaque morphology in sudden coronary death. J Am Coll Cardiol. 2010;55(2):122–32. https://doi.org/10.1016/j.jacc.2009.09.007.

Article  PubMed  Google Scholar 

Seegers LM, Araki M, Nakajima A, Yonetsu T, Minami Y, Ako J, et al. Sex differences in culprit plaque characteristics among different age groups in patients with Acute Coronary syndromes. Circ Cardiovasc Interv. 2022;15(6):e011612. https://doi.org/10.1161/circinterventions.121.011612.

Article  PubMed  Google Scholar 

Jia H, Abtahian F, Aguirre AD, Lee S, Chia S, Lowe H, et al. In vivo diagnosis of plaque erosion and calcified nodule in patients with acute coronary syndrome by intravascular optical coherence tomography. J Am Coll Cardiol. 2013;62(19):1748–58. https://doi.org/10.1016/j.jacc.2013.05.071.

Article  PubMed  Google Scholar 

Niccoli G, Montone RA, Di Vito L, Gramegna M, Refaat H, Scalone G, et al. Plaque rupture and intact fibrous cap assessed by optical coherence tomography portend different outcomes in patients with acute coronary syndrome. Eur Heart J. 2015;36(22):1377–84. https://doi.org/10.1093/eurheartj/ehv029.

Article  PubMed  Google Scholar 

Yonetsu T, Lee T, Murai T, Suzuki M, Matsumura A, Hashimoto Y, et al. Plaque morphologies and the clinical prognosis of acute coronary syndrome caused by lesions with intact fibrous cap diagnosed by optical coherence tomography. Int J Cardiol. 2016;203:766–74. https://doi.org/10.1016/j.ijcard.2015.11.030.

Article  PubMed  Google Scholar 

Kwon JE, Lee WS, Mintz GS, Hong YJ, Lee SY, Kim KS, et al. Multimodality Intravascular Imaging Assessment of Plaque Erosion versus Plaque rupture in patients with Acute Coronary Syndrome. Korean Circ J. 2016;46(4):499–506. https://doi.org/10.4070/kcj.2016.46.4.499.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park HC, Choi SI, Lee JU, Kim SG, Shin J, Kim HJ. Morphological findings in typical variant angina presenting as acute coronary syndrome using optical coherence tomography. J Interv Cardiol. 2013;26(5):491–500. https://doi.org/10.1111/joic.12060.

Article  PubMed  Google Scholar 

Shin ES, Ann SH, Singh GB, Lim KH, Yoon HJ, Hur SH, et al. OCT-Defined morphological characteristics of Coronary Artery Spasm sites in Vasospastic Angina. JACC Cardiovasc Imaging. 2015;8(9):1059–67. https://doi.org/10.1016/j.jcmg.2015.03.010.

Article  PubMed  Google Scholar 

Lerman A, Kwon TG, Lerman LO. Morphological characteristics of coronary arteries in patients with Vasospastic Angina: another form of atherosclerosis? JACC Cardiovasc Imaging. 2015;8(9):1068–70. https://doi.org/10.1016/j.jcmg.2015.05.008.

Article  PubMed  Google Scholar 

Russo M, Kim H