Inflammation in the Peri-ACS Period: Ready for Prime Time?

Matter MA, Paneni F, Libby P, Frantz S, Stähli BE, Templin C, et al. Inflammation in acute myocardial infarction: the good, the bad and the ugly. Eur Heart J. 2023;45(2):89–103.

Article  PubMed Central  Google Scholar 

Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, et al. 2023 ESC guidelines for the management of acute coronary syndromes: developed by the task force on the management of acute coronary syndromes of the European Society of Cardiology (ESC). Eur Heart J. 2023;44(38):3720–826.

Article  PubMed  Google Scholar 

Timmis A, Vardas P, Townsend N, Torbica A, Katus H, De Smedt D, et al. European Society of Cardiology: cardiovascular disease statistics 2021. Eur Heart J. 2022;43(8):716–99.

Article  PubMed  Google Scholar 

Ridker PM, Bhatt DL, Pradhan AD, Glynn RJ, MacFadyen JG, Nissen SE. Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials. Lancet. 2023;401(10384):1293–301.

Article  PubMed  Google Scholar 

Tucker B, Vaidya K, Cochran BJ, Patel S. Inflammation during percutaneous coronary intervention-prognostic value, mechanisms and therapeutic targets. Cells. 2021;10(6).

Tedgui A, Mallat Z. Cytokines in atherosclerosis: pathogenic and Regulatory pathways. Physiol Rev. 2006;86(2):515–81.

Article  PubMed  Google Scholar 

Tousoulis D, Oikonomou E, Economou EK, Crea F, Kaski JC. Inflammatory cytokines in atherosclerosis: current therapeutic approaches. Eur Heart J. 2016;37(22):1723–32.

Article  PubMed  Google Scholar 

Westman Peter C, Lipinski Michael J, Luger D, Waksman R, Bonow Robert O, Wu E, et al. Inflammation as a driver of adverse left ventricular remodeling after Acute myocardial infarction. J Am Coll Cardiol. 2016;67(17):2050–60.

Article  PubMed  Google Scholar 

Jackson SP, Darbousset R, Schoenwaelder SM. Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms. Blood. 2019;133(9):906–18.

Article  PubMed  Google Scholar 

Vaidya K, Tucker B, Kurup R, Khandkar C, Pandzic E, Barraclough J, et al. Colchicine inhibits Neutrophil Extracellular trap formation in patients with Acute Coronary Syndrome after Percutaneous Coronary intervention. J Am Heart Association. 2021;10(1):e018993.

Article  Google Scholar 

Martínez GJ, Robertson S, Barraclough J, Xia Q, Mallat Z, Bursill C et al. Colchicine acutely suppresses local Cardiac production of inflammatory cytokines in patients with an Acute Coronary Syndrome. J Am Heart Association.4(8):e002128.

Shah B, Pillinger M, Zhong H, Cronstein B, Xia Y, Lorin JD, et al. Effects of Acute Colchicine Administration Prior to Percutaneous Coronary Intervention. Circ Cardiovasc Interv. 2020;13(4):e008717.

Interleukin-6 receptor. Pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet. 2012;379(9822):1205–13.

Article  Google Scholar 

Mani P, Puri R, Schwartz GG, Nissen SE, Shao M, Kastelein JJP, et al. Association of Initial and serial C-Reactive protein levels with adverse Cardiovascular events and death after Acute Coronary Syndrome: a secondary analysis of the VISTA-16 trial. JAMA Cardiol. 2019;4(4):314–20.

Article  PubMed  PubMed Central  Google Scholar 

Mincu R-I, Jánosi RA, Vinereanu D, Rassaf T, Totzeck M. Preprocedural C-Reactive protein predicts outcomes after primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction a systematic meta-analysis. Sci Rep. 2017;7(1):41530.

Article  PubMed  PubMed Central  Google Scholar 

Hofmann U, Frantz S. Role of T-cells in myocardial infarction. Eur Heart J. 2015;37(11):873–9.

Article  PubMed  Google Scholar 

Ilatovskaya DV, Pitts C, Clayton J, Domondon M, Troncoso M, Pippin S, et al. CD8 + T-cells negatively regulate inflammation post-myocardial infarction. Am J Physiol Heart Circ Physiol. 2019;317(3):H581–96.

Article  PubMed  PubMed Central  Google Scholar 

Silverman HS, Pfeifer MP. Relation between use of antiinflammatory agents and left ventricular free wall rupture during acute myocardial infarction. Am J Cardiol. 1987;59(4):363–4.

Article  PubMed  Google Scholar 

Bally M, Dendukuri N, Rich B, Nadeau L, Helin-Salmivaara A, Garbe E, et al. Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data. BMJ. 2017;357:j1909.

Article  PubMed  PubMed Central  Google Scholar 

Ridker PM, Everett BM, Pradhan A, MacFadyen JG, Solomon DH, Zaharris E, et al. Low-dose methotrexate for the Prevention of atherosclerotic events. N Engl J Med. 2019;380(8):752–62.

Article  PubMed  Google Scholar 

Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, et al. Antiinflammatory therapy with Canakinumab for atherosclerotic disease. N Engl J Med. 2017;377(12):1119–31.

Article  PubMed  Google Scholar 

Abbate A, Kontos MC, Grizzard JD, Biondi-Zoccai GG, Van Tassell BW, Robati R, et al. Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study). Am J Cardio. 2010;105(10):1371-7.e1.

Article  Google Scholar 

Abbate A, Van Tassell BW, Biondi-Zoccai G, Kontos MC, Grizzard JD, Spillman DW, et al. Effects of interleukin-1 blockade with anakinra on adverse cardiac remodeling and heart failure after acute myocardial infarction [from the Virginia Commonwealth University-Anakinra Remodeling Trial (2) (VCU-ART2) pilot study]. Am J Cardiol. 2013;111(10):1394–400.

Article  PubMed  PubMed Central  Google Scholar 

Abbate A, Trankle CR, Buckley LF, Lipinski MJ, Appleton D, Kadariya D, et al. Interleukin-1 blockade inhibits the Acute Inflammatory response in patients with ST‐Segment–elevation myocardial infarction. J Am Heart Association. 2020;9(5):e014941.

Article  Google Scholar 

Morton AC, Rothman AMK, Greenwood JP, Gunn J, Chase A, Clarke B, et al. The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study. Eur Heart J. 2014;36(6):377–84.

Article  PubMed  PubMed Central  Google Scholar 

Broch K, Anstensrud Anne K, Woxholt S, Sharma K, Tøllefsen Ingvild M, Bendz B, et al. Randomized Trial of Interleukin-6 receptor inhibition in patients with Acute ST-Segment Elevation myocardial infarction. J Am Coll Cardiol. 2021;77(15):1845–55.

Article  PubMed  Google Scholar 

Kleveland O, Kunszt G, Bratlie M, Ueland T, Broch K, Holte E, et al. Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial†. Eur Heart J. 2016;37(30):2406–13.

Article  PubMed  Google Scholar 

Ridker PM, Devalaraja M, Baeres FMM, Engelmann MDM, Hovingh GK, Ivkovic M, et al. IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial. Lancet. 2021;397(10289):2060–9.

Article  PubMed  Google Scholar 

ARTEMIS - Effects of Ziltivekimab Versus Placebo on Cardiovascular Outcomes in Patients With Acute Myocardial Infarction [Internet]. 2023. https://clinicaltrials.gov/study/NCT06118281

Tardif JC, Kouz S, Waters DD, Bertrand OF, Diaz R, Maggioni AP, et al. Efficacy and safety of low-dose colchicine after myocardial infarction. N Engl J Med. 2019;381(26):2497–505.

Article  PubMed  Google Scholar 

Mewton N, Roubille F, Bresson D, Prieur C, Bouleti C, Bochaton T, et al. Effect of Colchicine on Myocardial Injury in Acute myocardial infarction. Circulation. 2021;144(11):859–69.

Article  PubMed  PubMed Central  Google Scholar 

Jolly SS, d’Entremont M-A, Lee SF, Mian R, Tyrwhitt J, Kedev S et al. Colchicine in Acute Myocardial Infarction. New England Journal of Medicine.0(0).

Tucker B, Kurup R, Barraclough J, Henriquez R, Cartland S, Arnott C, et al. Colchicine as a novel therapy for suppressing chemokine production in patients with an Acute Coronary Syndrome: a pilot study. Clin Ther. 2019;41(10):2172–81.

Article  PubMed  Google Scholar 

Bouabdallaoui N, Tardif J-C, Waters DD, Pinto FJ, Maggioni AP, Diaz R, et al. Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular outcomes Trial (COLCOT). Eur Heart J. 2020;41(42):4092–9.

Article  PubMed  PubMed Central  Google Scholar 

Tong DC, Bloom JE, Quinn S, Nasis A, Hiew C, Roberts-Thomson P, et al. Colchicine in patients with Acute Coronary Syndrome: two-year Follow-Up of the Australian COPS randomized clinical trial. Circulation. 2021;144(19):1584–6.

Article  PubMed  Google Scholar 

Tong DC, Quinn S, Nasis A, Hiew C, Roberts-Thomson P, Adams H, et al. Colchicine in patients with Acute Coronary Syndrome. Circulation. 2020;142(20):1890–900.

Article  PubMed  Google Scholar 

Hennessy T, Soh L, Bowman M, Kurup R, Schultz C, Patel S, et al. The low dose colchicine after myocardial infarction (LoDoCo-MI) study: a pilot randomized placebo controlled trial of colchicine following acute myocardial infarction. Am Heart J. 2019;215:62–9.

Article  PubMed 

留言 (0)

沒有登入
gif