Lethal versus surviving sepsis phenotypes displayed a partly differential regional expression of neurotransmitters and inflammation and did not modify the blood–brain barrier permeability in female CLP mice

Iskander KN, Osuchowski MF, Stearns-Kurosawa DJ, Kurosawa S, Stepien D, Valentine C, Remick DG (2013) Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol Rev 93(3):1247–1288

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gofton TE, Young GB (2012) Sepsis-associated encephalopathy. Nat Rev Neurol 8(10):557–566

Article  PubMed  CAS  Google Scholar 

Papadopoulos MC, Davies DC, Moss RF, Tighe D, Bennett ED (2000) Pathophysiology of septic encephalopathy: a review. Crit Care Med 28(8):3019–3024

Article  PubMed  CAS  Google Scholar 

Ebersoldt M, Sharshar T, Annane D (2007) Sepsis-associated delirium. Intensive Care Med 33:941–950

Article  PubMed  Google Scholar 

Witt NJ, Zochodne DW, Bolton CF, Grand’Maison F, Wells G, Young GB, Sibbald WJ (1991) Peripheral nerve function in sepsis and multiple organ failure. Chest 99(1):176–184

Article  PubMed  CAS  Google Scholar 

Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, Brummel NE, Hughes CG, Vasilevskis EE, Shintani AK, Moons KG (2013) Long-term cognitive impairment after critical illness. N Engl J Med 369(14):1306–1316

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cavallazzi R, Saad M, Marik PE (2012) Delirium in the ICU: an overview. Ann Intensive Care 2:1–1

Article  Google Scholar 

Hosokawa K, Gaspard N, Su F, Oddo M, Vincent JL, Taccone FS (2014) Clinical neurophysiological assessment of sepsis-associated brain dysfunction: a systematic review. Crit Care 18:1–2

Article  Google Scholar 

Semmler A, Widmann CN, Okulla T, Urbach H, Kaiser M, Widman G, Mormann F, Weide J, Fliessbach K, Hoeft A, Jessen F (2013) Persistent cognitive impairment, hippocampal atrophy and EEG changes in sepsis survivors. J Neurol Neurosurg Psychiatry 84(1):62–69

Article  PubMed  Google Scholar 

Hirano H, Day J, Fibiger HC (1995) Serotonergic regulation of acetylcholine release in rat frontal cortex. J Neurochem 65(3):1139–1145

Article  PubMed  CAS  Google Scholar 

Platt MM, Breitbart W, Smith M, Marotta R, Weisman H, Jacobsen PB (1994) Efficacy of neuroleptics for hypoactive delirium. J Neuropsychiatry Clin Neurosci 6:66–67

Article  PubMed  CAS  Google Scholar 

Chan CH, Liu HC, Huang MC (2006) Delirium associated with concomitant use of low-dose bupropion sustained release and fluoxetine. J Clin Psychopharmacol 26(6):677–679

Article  PubMed  Google Scholar 

Cheon SY, Song J (2021) The association between hepatic encephalopathy and diabetic encephalopathy: the brain-liver axis. Int J Mol Sci 22(1):463

Article  PubMed  PubMed Central  CAS  Google Scholar 

Francescangeli J, Karamchandani K, Powell M, Bonavia A (2019) The serotonin syndrome: from molecular mechanisms to clinical practice. Int J Mol Sci 20(9):2288

Article  PubMed  PubMed Central  CAS  Google Scholar 

Berg RM, Taudorf S, Bailey DM, Lundby C, Larsen FS, Pedersen BK, Møller K (2010) Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans. Crit Care 14:1–8

Article  Google Scholar 

Flacker JM, Lipsitz LA (2000) Large neutral amino acid changes and delirium in febrile elderly medical patients. J Gerontol A Biol Sci Med Sci 55(5):B249–B252

Article  PubMed  CAS  Google Scholar 

Robinson TN, Raeburn CD, Angles EM, Moss M (2008) Low tryptophan levels are associated with postoperative delirium in the elderly. Am J Surg 196(5):670–674

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wilson JR, Morandi A, Girard TD, Thompson JL, Boomershine CS, Shintani AK, Ely EW, Pandharipande PP (2012) The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness. Crit Care Med 40(3):835–841

Article  Google Scholar 

Quan N, Banks WA (2007) Brain-immune communication pathways. Brain Behav Immun 21(6):727–735

Article  PubMed  CAS  Google Scholar 

Michels M, Steckert AV, Quevedo J, Barichello T, Dal-Pizzol F (2015) Mechanisms of long-term cognitive dysfunction of sepsis: from blood–borne leukocytes to glial cells. Intensive Care Med Exp 3:1–3

Article  Google Scholar 

Mazeraud A, Righy C, Bouchereau E, Benghanem S, Bozza FA, Sharshar T (2020) Septic-associated encephalopathy: a comprehensive review. Neurotherapeutics 17(2):392–403

Article  PubMed  PubMed Central  Google Scholar 

Catarina AV, Branchini G, Bettoni L, De Oliveira JR, Nunes FB (2021) Sepsis-associated encephalopathy: from pathophysiology to progress in experimental studies. Mol Neurobiol 58:2770–2779

Article  PubMed  CAS  Google Scholar 

Schain M, Kreisl WC (2017) Neuroinflammation in neurodegenerative disorders—a review. Curr Neurol Neurosci Rep 17:1–1

Article  CAS  Google Scholar 

Chamorro A, Meisel A, Planas AM, Urra X, Van De Beek D, Veltkamp R (2012) The immunology of acute stroke. Nat Rev Neurol 8(7):401–410

Article  PubMed  CAS  Google Scholar 

Jiang S, Shi D, Bai L, Niu T, Kang R, Liu Y (2023) Inhibition of interleukin-6 trans-signaling improves survival and prevents cognitive impairment in a mouse model of sepsis. Int Immunopharmacol 1(119):110169

Article  Google Scholar 

Tian Y, Wang L, Fan X, Zhang H, Dong Z, Tao T (2023) β-patchoulene alleviates cognitive dysfunction in a mouse model of sepsis associated encephalopathy by inhibition of microglia activation through Sirt1/Nrf2 signaling pathway. PLoS ONE 18(1):e0279964

Article  PubMed  PubMed Central  CAS  Google Scholar 

Comim CM, Vilela MC, Constantino LS, Petronilho F, Vuolo F, Lacerda-Queiroz N, Rodrigues DH, Da Rocha JL, Teixeira AL, Quevedo J, Dal-Pizzol F (2011) Traffic of leukocytes and cytokine up-regulation in the central nervous system in sepsis. Intensive Care Med 37:711–718

Article  PubMed  CAS  Google Scholar 

Ye B, Tao T, Zhao A, Wen L, He X, Liu Y, Fu Q, Mi W, Lou J (2019) Blockade of IL-17A/IL-17R pathway protected mice from sepsis-associated encephalopathy by inhibition of microglia activation. Mediators Inflamm 7:2019

Google Scholar 

Reis PA, Alexandre PC, D’Avila JC, Siqueira LD, Antunes B, Estato V, Tibiriça EV, Verdonk F, Sharshar T, Chrétien F, Castro-Faria-Neto HC (2017) Statins prevent cognitive impairment after sepsis by reverting neuroinflammation, and microcirculatory/endothelial dysfunction. Brain Behav Immun 1(60):293–303

Article  Google Scholar 

Wichterman KA, Baue AE, Chaudry IH (1980) Sepsis and septic shock—a review of laboratory models and a proposal. J Surg Res 29(2):189–201

Article  PubMed  CAS  Google Scholar 

Rademann P, Weidinger A, Drechsler S, Meszaros A, Zipperle J, Jafarmadar M, Dumitrescu S, Hacobian A, Ungelenk L, Röstel F, Kaszaki J (2017) Mitochondria-targeted antioxidants SkQ1 and MitoTEMPO failed to exert a long-term beneficial effect in murine polymicrobial sepsis. Oxid Med Cell Longev. https://doi.org/10.1155/2017/6412682

Article  PubMed  PubMed Central  Google Scholar 

Drechsler S, Weixelbaumer KM, Weidinger A, Raeven P, Khadem A, Redl H, Van Griensven M, Bahrami S, Remick D, Kozlov A, Osuchowski MF (2015) Why do they die? Comparison of selected aspects of organ injury and dysfunction in mice surviving and dying in acute abdominal sepsis. Intensive Care Med Exp 3:1–21

Article  Google Scholar 

Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman C, Drechsler S, Efron P (2018) Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Intensive Care Med Exp 6:1–6

Article 

留言 (0)

沒有登入
gif