Glycemic control by treatment modalities: national registry-based population data in children and adolescents with type 1 diabetes

Hormone Research in Paediatrics

Research Article

Open Access Gateway Sumnik Z. · Pavlikova M. · Neuman V. · Petruzelkova L. · Konecna P. · Venhacova P. · Skvor J. · Pomahacova R. · Neumann D. · Vosahlo J. · Strnadel J. · Kocourková K. · Obermannova B. · Santova A. · Plachy L. · Pruhova S. · Cinek O.
Abstract

AIMS To assess the differences in key parameters of type 1 diabetes (T1D) control associated with treatment and monitoring modalities including newly introduced hybrid closed-loop (HCL) algorithm in children and adolescents with T1D (CwD) using the data from the population-wide pediatric diabetes registry ČENDA. MATERIALS AND METHODS CwD younger than 19 years with T1D duration > 1 year were included and divided according to the treatment modality and type of CGM used: multiple daily injection (MDI), insulin pump without (CSII) and with HCL function, intermittently scanned continuous glucose monitoring (isCGM), real-time CGM (rtCGM), and intermittent or no CGM (noCGM). HbA1c, times in glycemic ranges, and glucose risk index (GRI) were compared between the groups. RESULTS Data of a total of 3251 children (mean age 13.4± years) were analyzed. 2187 (67.3%) were treated with MDI, 1064 (32.7%) with insulin pump, 585/1064 (55%) with HCL. The HCL users achieved the highest median TIR 75.4% (IQR 6.3), and GRI 29.1 (7.8), both p

The Author(s). Published by S. Karger AG, Basel

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HORMONE RESEARCH IN PAEDIATRICS

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