Research ArticleHematologyOncology Open Access | 10.1172/JCI173770

Laura Ondrisova,1,2 Vaclav Seda,1,2 Krystof Hlavac,1,2 Petra Pavelkova,1,2 Eva Hoferkova,1,2 Giorgia Chiodin,3 Lenka Kostalova,1,2 Gabriela Mladonicka Pavlasova,1 Daniel Filip,1,2 Josef Vecera,1,2 Pedro Faria Zeni,1 Jan Oppelt,1 Zuzana Kahounova,4 Rachel Vichova,4 Karel Soucek,4 Anna Panovska,2 Karla Plevova,2 Sarka Pospisilova,2 Martin Simkovic,5 Filip Vrbacky,5 Daniel Lysak,6 Stacey M. Fernandes,7 Matthew S. Davids,7 Alba Maiques-Diaz,8 Stella Charalampopoulou,8 Jose I. Martin-Subero,8 Jennifer R. Brown,7 Michael Doubek,2 Francesco Forconi,3,9 Jiri Mayer,2 and Marek Mraz1,2

1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

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1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

Find articles by Martin-Subero, J. in: JCI | PubMed | Google Scholar

1Molecular Medicine, CEITEC Masaryk University, Brno, Czechia.

2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia.

3Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

4Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.

5Fourth Department of Internal Medicine–Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czechia.

6Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

8Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

9Haematology Department, Cancer Care Directorate, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

Address correspondence to: Marek Mraz, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czechia. Phone: 420.549498143; Email: marek.mraz@email.cz.

Find articles by Brown, J. in: JCI | PubMed |