Research ArticleNephrology Open Access | 10.1172/JCI180347

Silvana Bazua-Valenti,1,2,3 Matthew R. Brown,1 Jason Zavras,1 Magdalena Riedl Khursigara,1 Elizabeth Grinkevich,1 Eriene-Heidi Sidhom,1,2 Keith H. Keller,1,4 Matthew Racette,1 Moran Dvela-Levitt,1,5 Catarina Quintanova,6 Hasan Demirci,7,8 Sebastian Sewerin,1 Alissa C. Goss,1,2 John Lin,1 Hyery Yoo,1 Alvaro S. Vaca Jacome,9 Malvina Papanastasiou,9 Namrata Udeshi,9 Steven A. Carr,9 Nina Himmerkus,6 Markus Bleich,6 Kerim Mutig,7,8 Sebastian Bachmann,7,8 Jan Halbritter,10 Stanislav Kmoch,11 Martina Živná,11 Kendrah Kidd,12 Anthony J. Bleyer,12 Astrid Weins,4 Seth L. Alper,1,13 Jillian L. Shaw,1 Maria Kost-Alimova,1 Juan Lorenzo B. Pablo,1 and Anna Greka1,2

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Bazua-Valenti, S. in: JCI | PubMed | Google Scholar

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Brown, M. in: JCI | PubMed | Google Scholar

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Zavras, J. in: JCI | PubMed | Google Scholar

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Riedl Khursigara, M. in: JCI | PubMed | Google Scholar

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Grinkevich, E. in: JCI | PubMed | Google Scholar

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Sidhom, E. in: JCI | PubMed | Google Scholar |

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Keller, K. in: JCI | PubMed | Google Scholar

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Racette, M. in: JCI | PubMed | Google Scholar

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Dvela-Levitt, M. in: JCI | PubMed | Google Scholar

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Quintanova, C. in: JCI | PubMed | Google Scholar

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Demirci, H. in: JCI | PubMed | Google Scholar |

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Sewerin, S. in: JCI | PubMed | Google Scholar

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Goss, A. in: JCI | PubMed | Google Scholar

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Lin, J. in: JCI | PubMed | Google Scholar

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Yoo, H. in: JCI | PubMed | Google Scholar

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Vaca Jacome, A. in: JCI | PubMed | Google Scholar

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Papanastasiou, M. in: JCI | PubMed | Google Scholar |

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Udeshi, N. in: JCI | PubMed | Google Scholar

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Carr, S. in: JCI | PubMed | Google Scholar |

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Himmerkus, N. in: JCI | PubMed | Google Scholar

1The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

5The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

6Institute of Physiology, Christian - Albrechts - Universität, Kiel, Germany.

7Institute of Translational Physiology and

8Department of Anatomy, Charité - Universitätsmedizin, Berlin, Germany.

9Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

10Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

11Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

12Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina, USA.

13Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Anna Greka, Broad Institute of MIT and Harvard, 75 Ames St., Cambridge, Massachusetts 02142, USA. Email: agreka@broadinstitute.org.

Find articles by Bleich, M. in: