Gut-Derived Short-Chain Fatty Acids and Macrophage Modulation: Exploring Therapeutic Potentials in Pulmonary Fungal Infections

Zhang S, Zhao J, Xie F et al (2021) Dietary fiber-derived short-chain fatty acids: a potential therapeutic target to alleviate obesity-related nonalcoholic fatty liver disease. Obes Rev 22(11):e13316. https://doi.org/10.1111/obr.13316

Article  CAS  PubMed  Google Scholar 

Sun M, Wu W, Liu Z et al (2017) Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases. J Gastroenterol 52(1):1–8. https://doi.org/10.1007/s00535-016-1242-9

Article  CAS  PubMed  Google Scholar 

Ziętek M, Celewicz Z, Szczuko M (2021) Short-chain fatty acids, maternal microbiota, and metabolism in pregnancy. Nutrients 13(4):1244. https://doi.org/10.3390/nu13041244

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dang AT, Marsland BJ (2019) Microbes, metabolites, and the gut-lung axis. Mucosal Immunol 12(4):843–850. https://doi.org/10.1038/s41385-019-0160-6

Article  CAS  PubMed  Google Scholar 

Betancourt S (2019) Opportunistic fungal infection. Chest Imaging. https://doi.org/10.1093/MED/9780199858064.003.0037

Article  Google Scholar 

Henao-Martínez AF, Corbisiero MF, Salter I et al (2023) Invasive pulmonary aspergillosis real-world outcomes: clinical features and risk factors associated with increased mortality. Med Mycol 61(8):myad074. https://doi.org/10.1093/mmy/myad074

Article  CAS  PubMed  Google Scholar 

Corcione S, Lupia T, Raviolo S et al (2021) Putative invasive pulmonary aspergillosis within medical wards and intensive care units: a 4-year retrospective observational single-centre study. Intern Emerg Med 16:1619–1627. https://doi.org/10.1007/s11739-021-02705-z

Article  PubMed  PubMed Central  Google Scholar 

Beltrame A, Stevens DA, Haiduven D (2023) Mortality in ICU patients with COVID-19-associated pulmonary aspergillosis. J Fungi 9(6):689. https://doi.org/10.3390/jof9060689

Article  Google Scholar 

Hérivaux A, Willis JR, Mercier T et al (2022) Lung microbiota predict invasive pulmonary aspergillosis and its outcome in immunocompromised patients. Thorax 77(3):283–291. https://doi.org/10.1136/thoraxjnl-2020-216179

Article  PubMed  Google Scholar 

Heung LJ, Wiesner DL, Wang K et al (2023) Immunity to fungi in the lung. Semin Immunol 66:101728. https://doi.org/10.1016/j.smim.2023.101728

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kuboyama T, Wahane S, Huang Y et al (2017) HDAC3 inhibition ameliorates spinal cord injury by immunomodulation. Sci Rep 7:08535–08544. https://doi.org/10.1038/s41598-017-08535-4

Article  CAS  Google Scholar 

Li M, Esch B, Henricks P et al (2018) The anti-inflammatory effects of short chain fatty acids on lipopolysaccharide- or tumor necrosis factor α-stimulated endothelial cells via activation of GPR41/43 and inhibition of HDACs. Front Pharmacol 9:00533. https://doi.org/10.3389/fphar.2018.00533

Article  CAS  Google Scholar 

Sanchez H, Moroney J, Gan H et al (2020) B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids. Nat Commun 11:13603–13606. https://doi.org/10.1038/s41467-019-13603-6

Article  CAS  Google Scholar 

Butterfield TA, Best TM, Merrick MA (2006) The dual roles of neutrophils and macrophages in inflammation: a critical balance between tissue damage and repair. J Athl Train 41(4):457–465

PubMed  PubMed Central  Google Scholar 

Wu T, Li H, Su C et al (2020) Microbiota-derived short-chain fatty acids promote LAMTOR2-mediated immune responses in macrophages. mSystems 5(6):e00587-20. https://doi.org/10.1128/mSystems.00587-20

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schulthess J, Pandey S, Capitani M et al (2019) The short chain fatty acid butyrate imprints an antimicrobial program in macrophages. Immunity 50(2):432–45.e7. https://doi.org/10.1016/j.immuni.2018.12.018

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cox MA, Jackson J, Stanton M et al (2009) Short-chain fatty acids act as anti-inflammatory mediators by regulating prostaglandin E(2) and cytokines. World J Gastroenterol 15(44):5549–5557. https://doi.org/10.3748/wjg.15.5549

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maa MC, Chang MY, Hsieh MY et al (2010) Butyrate reduced lipopolysaccharide-mediated macrophage migration by suppression of Src enhancement and focal adhesion kinase activity. J Nutr Biochem 21(12):1186–1192. https://doi.org/10.1016/j.jnutbio.2009.10.004

Article  CAS  PubMed  Google Scholar 

Nakkarach A, Foo HL, Song AA et al (2021) Anti-cancer and anti-inflammatory effects elicited by short chain fatty acids produced by Escherichia coli isolated from healthy human gut microbiota. Microb Cell Fact 20(1):36. https://doi.org/10.1186/s12934-020-01477-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eslick S, Williams EJ, Berthon BS et al (2022) Weight loss and short-chain fatty acids reduce systemic inflammation in monocytes and adipose tissue macrophages from obese subjects. Nutrients 14(4):765. https://doi.org/10.3390/nu14040765

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsugawa H, Kabe Y, Kanai A et al (2020) Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection. PLoS Biol 18(9):e3000813. https://doi.org/10.1371/journal.pbio.3000813

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park JW, Kim HY, Kim MG et al (2019) Short-chain fatty acids inhibit staphylococcal lipoprotein-induced nitric oxide production in murine macrophages. Immune Netw 19(2):e9. https://doi.org/10.4110/in.2019.19.e9

Article  PubMed  PubMed Central  Google Scholar 

Masui R, Sasaki M, Funaki Y et al (2013) G protein-coupled receptor 43 moderates gut inflammation through cytokine regulation from mononuclear cells. Inflamm Bowel Dis 19(13):2848–2856. https://doi.org/10.1097/01.MIB.0000435444.14860.ea

Article  PubMed  Google Scholar 

Carbone AM, Borges JI, Suster MS et al (2022) Regulator of G-protein signaling-4 attenuates cardiac adverse remodeling and neuronal norepinephrine release-promoting free fatty acid receptor FFAR3 signaling. Int J Mol Sci 23(10):5803. https://doi.org/10.3390/ijms23105803

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zapolska-Downar D, Naruszewicz M (2009) Propionate reduces the cytokine-induced VCAM-1 and ICAM-1 expression by inhibiting nuclear factor-kappa B (NF-kappaB) activation. J Physiol Pharmacol 60(2):123–131

CAS  PubMed  Google Scholar 

Poelaert KCK, Van Cleemput J, Laval K et al (2019) Beyond gut instinct: metabolic short-chain fatty acids moderate the pathogenesis of alphaherpesviruses. Front Microbiol 10:723. https://doi.org/10.3389/fmicb.2019.00723

Article  PubMed  PubMed Central  Google Scholar 

Wang Y, Pawar S, Dutta O et al (2022) Macrophage mediated immunomodulation during Cryptococcus pulmonary infection. Front Cell Infect Microbiol 12:859049. https://doi.org/10.3389/fcimb.2022.859049

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sarkar A, Mitra P, Lahiri A et al (2023) Butyrate limits inflammatory macrophage niche in NASH. Cell Death Dis 14(5):332. https://doi.org/10.1038/s41419-023-05853-6

Article  CAS  PubMed  PubMed Central 

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