Research ArticleInflammationVascular biology Open Access | 10.1172/jci.insight.158127

Francesco Potì,1,2 Enrica Scalera,3,4 Renata Feuerborn,4 Josephine Fischer,5 Lilli Arndt,6 Georg Varga,7 Evangelia Pardali,8,9 Matthias D. Seidl,10 Manfred Fobker,4 Gerhard Liebisch,11 Bettina Hesse,12 Alexander H. Lukasz,12 Jan Rossaint,13 Beate E. Kehrel,13 Frank Rosenbauer,5 Thomas Renné,14,15,16 Christina Christoffersen,17 Manuela Simoni,2 Ralph Burkhardt,11 and Jerzy-Roch Nofer2,4,14,18

1Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, Parma, Italy.

2Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.

3Department of Food and Drug, University of Parma, Parma, Italy.

4Central Laboratory Facility, University Hospital Münster, Münster, Germany.

5Institute of Molecular Tumor Biology, University of Münster, Münster, Germany.

6Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany.

7Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Münster, Münster, Germany.

8Department of Cardiology, University Hospital Münster, Münster, Germany.

9Pharvaris GmbH, Zug, Switzerland.

10Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

11Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.

12Division of General Internal Medicine, Nephrology, and Rheumatology, Department of Medicine D, and

13Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.

14Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

15Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

16Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, Mainz, Germany.

17Department of Clinical Biochemistry, Rigshospitalet, and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

18Institute for Laboratory Medicine, Marien-Hospital, Niels-Stensen-Kliniken, Osnabrück, Germany.

Address correspondence to: Jerzy-Roch Nofer, Zentrale Einrichtung UKM Labor, Universitätsklinikum Münster, Albert-Schweizer-Campus 1, Geb. A1, 48149 Münster, Germany. Phone: 49.251.83.47228; Email: nofer@uni-muenster.de. Or to: Ralph Burkhardt, Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany. Phone: 49.941.944.6201; Email: Ralph.Burkhardt@klinik.uni-regensburg.de.

Authorship note: FP and ES contributed equally to this work. RB and JRN contributed equally to this work.

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1Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, Parma, Italy.

2Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.

3Department of Food and Drug, University of Parma, Parma, Italy.

4Central Laboratory Facility, University Hospital Münster, Münster, Germany.

5Institute of Molecular Tumor Biology, University of Münster, Münster, Germany.

6Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany.

7Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Münster, Münster, Germany.

8Department of Cardiology, University Hospital Münster, Münster, Germany.

9Pharvaris GmbH, Zug, Switzerland.

10Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

11Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.

12Division of General Internal Medicine, Nephrology, and Rheumatology, Department of Medicine D, and

13Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.

14Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

15Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

16Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, Mainz, Germany.

17Department of Clinical Biochemistry, Rigshospitalet, and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

18Institute for Laboratory Medicine, Marien-Hospital, Niels-Stensen-Kliniken, Osnabrück, Germany.

Address correspondence to: Jerzy-Roch Nofer, Zentrale Einrichtung UKM Labor, Universitätsklinikum Münster, Albert-Schweizer-Campus 1, Geb. A1, 48149 Münster, Germany. Phone: 49.251.83.47228; Email: nofer@uni-muenster.de. Or to: Ralph Burkhardt, Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany. Phone: 49.941.944.6201; Email: Ralph.Burkhardt@klinik.uni-regensburg.de.

Authorship note: FP and ES contributed equally to this work. RB and JRN contributed equally to this work.

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1Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, Parma, Italy.

2Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.

3Department of Food and Drug, University of Parma, Parma, Italy.

4Central Laboratory Facility, University Hospital Münster, Münster, Germany.

5Institute of Molecular Tumor Biology, University of Münster, Münster, Germany.

6Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany.

7Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Münster, Münster, Germany.

8Department of Cardiology, University Hospital Münster, Münster, Germany.

9Pharvaris GmbH, Zug, Switzerland.

10Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

11Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.

12Division of General Internal Medicine, Nephrology, and Rheumatology, Department of Medicine D, and

13Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.

14Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

15Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

16Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, Mainz, Germany.

17Department of Clinical Biochemistry, Rigshospitalet, and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

18Institute for Laboratory Medicine, Marien-Hospital, Niels-Stensen-Kliniken, Osnabrück, Germany.

Address correspondence to: Jerzy-Roch Nofer, Zentrale Einrichtung UKM Labor, Universitätsklinikum Münster, Albert-Schweizer-Campus 1, Geb. A1, 48149 Münster, Germany. Phone: 49.251.83.47228; Email: nofer@uni-muenster.de. Or to: Ralph Burkhardt, Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany. Phone: 49.941.944.6201; Email: Ralph.Burkhardt@klinik.uni-regensburg.de.

Authorship note: FP and ES contributed equally to this work. RB and JRN contributed equally to this work.

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1Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, Parma, Italy.

2Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.

3Department of Food and Drug, University of Parma, Parma, Italy.

4Central Laboratory Facility, University Hospital Münster, Münster, Germany.

5Institute of Molecular Tumor Biology, University of Münster, Münster, Germany.

6Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany.

7Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Münster, Münster, Germany.

8Department of Cardiology, University Hospital Münster, Münster, Germany.

9Pharvaris GmbH, Zug, Switzerland.

10Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

11Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.

12Division of General Internal Medicine, Nephrology, and Rheumatology, Department of Medicine D, and

13Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.

14Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

15Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

16Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, Mainz, Germany.

17Department of Clinical Biochemistry, Rigshospitalet, and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

18Institute for Laboratory Medicine, Marien-Hospital, Niels-Stensen-Kliniken, Osnabrück, Germany.

Address correspondence to: Jerzy-Roch Nofer, Zentrale Einrichtung UKM Labor, Universitätsklinikum Münster, Albert-Schweizer-Campus 1, Geb. A1, 48149 Münster, Germany. Phone: 49.251.83.47228; Email: nofer@uni-muenster.de. Or to: Ralph Burkhardt, Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany. Phone: 49.941.944.6201; Email: Ralph.Burkhardt@klinik.uni-regensburg.de.

Authorship note: FP and ES contributed equally to this work. RB and JRN contributed equally to this work.

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1Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, Parma, Italy.

2Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.

3Department of Food and Drug, University of Parma, Parma, Italy.

4Central Laboratory Facility, University Hospital Münster, Münster, Germany.

5Institute of Molecular Tumor Biology, University of Münster, Münster, Germany.

6Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany.

7Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Münster, Münster, Germany.

8Department of Cardiology, University Hospital Münster, Münster, Germany.

9Pharvaris GmbH, Zug, Switzerland.

10Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

11Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.

12Division of General Internal Medicine, Nephrology, and Rheumatology, Department of Medicine D, and

13Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.

14Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

15Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

16Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, Mainz, Germany.

17Department of Clinical Biochemistry, Rigshospitalet, and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

18Institute for Laboratory Medicine, Marien-Hospital, Niels-Stensen-Kliniken, Osnabrück, Germany.

Address correspondence to: Jerzy-Roch Nofer, Zentrale Einrichtung UKM Labor, Universitätsklinikum Münster, Albert-Schweizer-Campus 1, Geb. A1, 48149 Münster, Germany. Phone: 49.251.83.47228; Email: nofer@uni-muenster.de. Or to: Ralph Burkhardt, Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany. Phone: 49.941.944.6201; Email: Ralph.Burkhardt@klinik.uni-regensburg.de.

Authorship note: FP and ES contributed equally to this work. RB and JRN contributed equally to this work.

Find articles by Arndt, L. in: JCI | PubMed | Google Scholar

1Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, Parma, Italy.

2Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.

3Department of Food and Drug, University of Parma, Parma, Italy.

4Central Laboratory Facility, University Hospital Münster, Münster, Germany.

5Institute of Molecular Tumor Biology, University of Münster, Münster, Germany.

6Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany.

7Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Münster, Münster, Germany.

8Department of Cardiology, University Hospital Münster, Münster, Germany.

9Pharvaris GmbH, Zug, Switzerland.

10Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

11Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.

12Division of General Internal Medicine, Nephrology, and Rheumatology, Department of Medicine D, and

13Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.

14Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

15Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

16Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, Mainz, Germany.

17Department of Clinical Biochemistry, Rigshospitalet, and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

18Institute for Laboratory Medicine, Marien-Hospital, Niels-Stensen-Kliniken, Osnabrück, Germany.

Address correspondence to: Jerzy-Roch Nofer, Zentrale Einrichtung UKM Labor, Universitätsklinikum Münster, Albert-Schweizer-Campus 1, Geb. A1, 48149 Münster, Germany. Phone: 49.251.83.47228; Email: nofer@uni-muenster.de. Or to: Ralph Burkhardt, Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany. Phone: 49.941.944.6201; Email: Ralph.Burkhardt@klinik.uni-regensburg.de.

Authorship note: FP and ES contributed equally to this work. RB and JRN contributed equally to this work.

Find articles by Varga, G. in: JCI | PubMed | Google Scholar

1Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, Parma, Italy.

2Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.

3Department of Food and Drug, University of Parma, Parma, Italy.

4Central Laboratory Facility, University Hospital Münster, Münster, Germany.

5Institute of Molecular Tumor Biology, University of Münster, Münster, Germany.

6Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany.

7Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Münster, Münster, Germany.

8Department of Cardiology, University Hospital Münster, Münster, Germany.

9Pharvaris GmbH, Zug, Switzerland.

10Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

11Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.

12Division of General Internal Medicine, Nephrology, and Rheumatology, Department of Medicine D, and

13Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.

14Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

15Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

16Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, Mainz, Germany.

17Department of Clinical Biochemistry, Rigshospitalet, and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

18Institute for Laboratory Medicine, Marien-Hospital, Niels-Stensen-Kliniken, Osnabrück, Germany.

Address correspondence to: Jerzy-Roch Nofer, Zentrale Einrichtung UKM Labor, Universitätsklinikum Münster, Albert-Schweizer-Campus 1, Geb. A1, 48149 Münster, Germany. Phone: 49.251.83.47228; Email: nofer@uni-muenster.de. Or to: Ralph Burkhardt, Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany. Phone: 49.941.944.6201; Email: Ralph.Burkhardt@klinik.uni-regensburg.de.

Authorship note: FP and ES contributed equally to this work. RB and JRN contributed equally to this work.

Find articles by Pardali, E. in: JCI | PubMed | Google Scholar

1Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, Parma, Italy.

2Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.

3Department of Food and Drug, University of Parma, Parma, Italy.

4Central Laboratory Facility, University Hospital Münster, Münster, Germany.

5Institute of Molecular Tumor Biology, University of Münster, Münster, Germany.

6Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany.

7Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Münster, Münster, Germany.

8Department of Cardiology, University Hospital Münster, Münster, Germany.

9Pharvaris GmbH, Zug, Switzerland.

10Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

11Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.

12Division of General Internal Medicine, Nephrology, and Rheumatology, Department of Medicine D, and

13Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.

14Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

15Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

16Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, Mainz, Germany.

17Department of Clinical Biochemistry, Rigshospitalet, and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

18Institute for Laboratory Medicine, Marien-Hospital, Niels-Stensen-Kliniken, Osnabrück, Germany.

Address correspondence to: Jerzy-Roch Nofer, Zentrale Einrichtung UKM Labor, Universitätsklinikum Münster, Albert-Schweizer-Campus 1, Geb. A1, 48149 Münster, Germany. Phone: 49.251.83.47228; Email: nofer@uni-muenster.de. Or to: Ralph Burkhardt, Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany. Phone: 49.941.944.6201; Email: Ralph.Burkhardt@klinik.uni-regensburg.de.

Authorship note: FP and ES contributed equally to this work. RB and JRN contributed equally to this work.

Find articles by Seidl, M. in: JCI | PubMed | Google Scholar

1Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, Parma, Italy.

2Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.

3Department of Food and Drug, University of Parma, Parma, Italy.

4Central Laboratory Facility, University Hospital Münster, Münster, Germany.

5Institute of Molecular Tumor Biology, University of Münster, Münster, Germany.

6Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany.

7Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Münster, Münster, Germany.

8Department of Cardiology, University Hospital Münster, Münster, Germany.

9Pharvaris GmbH, Zug, Switzerland.

10Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

11Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.

12Division of General Internal Medicine, Nephrology, and Rheumatology, Department of Medicine D, and

13Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.

14Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

15Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

16Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, Mainz, Germany.

17Department of Clinical Biochemistry, Rigshospitalet, and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

18Institute for Laboratory Medicine, Marien-Hospital, Niels-Stensen-Kliniken, Osnabrück, Germany.

Address correspondence to: Jerzy-Roch Nofer, Zentrale Einrichtung UKM Labor, Universitätsklinikum Münster, Albert-Schweizer-Campus 1, Geb. A1, 48149 Münster, Germany. Phone: 49.251.83.47228; Email: nofer@uni-muenster.de. Or to: Ralph Burkhardt, Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany. Phone: 49.941.944.6201; Email: Ralph.Burkhardt@klinik.uni-regensburg.de.

Authorship note: FP and ES contributed equally to this work. RB and JRN contributed equally to this work.

Find articles by Fobker, M. in: JCI | PubMed | Google Scholar

1Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, Parma, Italy.

2Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.

3Department of Food and Drug, University of Parma, Parma, Italy.

4Central Laboratory Facility, University Hospital Münster, Münster, Germany.

5Institute of Molecular Tumor Biology, University of Münster, Münster, Germany.

6Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany.

7Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Münster, Münster, Germany.

8Department of Cardiology, University Hospital Münster, Münster, Germany.

9Pharvaris GmbH, Zug, Switzerland.

10Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

11Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.

12Division of General Internal Medicine, Nephrology, and Rheumatology, Department of Medicine D, and

13Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.

14Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

15Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

16Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, Mainz, Germany.

17Department of Clinical Biochemistry, Rigshospitalet, and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

18Institute for Laboratory Medicine, Marien-Hospital, Niels-Stensen-Kliniken, Osnabrück, Germany.

Address correspondence to: Jerzy-Roch Nofer, Zentrale Einrichtung UKM Labor, Universitätsklinikum Münster, Albert-Schweizer-Campus 1, Geb. A1, 48149 Münster, Germany. Phone: 49.251.83.47228; Email: nofer@uni-muenster.de. Or to: Ralph Burkhardt, Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany. Phone: 49.941.944.6201; Email: Ralph.Burkhardt@klinik.uni-regensburg.de.

Authorship note: FP and ES contributed equally to this work. RB and JRN contributed equally to this work.

Find articles by Liebisch, G. in: JCI | PubMed | Google Scholar |

1Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, Parma, Italy.

2Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.

3Department of Food and Drug, University of Parma, Parma, Italy.

4Central Laboratory Facility, University Hospital Münster, Münster, Germany.

5Institute of Molecular Tumor Biology, University of Münster, Münster, Germany.

6Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany.

7Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Münster, Münster, Germany.

8Department of Cardiology, University Hospital Münster, Münster, Germany.

9Pharvaris GmbH, Zug, Switzerland.

10Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

11Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.

12Division of General Internal Medicine, Nephrology, and Rheumatology, Department of Medicine D, and

13Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.

14Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

15Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

16Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, Mainz, Germany.

17Department of Clinical Biochemistry, Rigshospitalet, and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

18Institute for Laboratory Medicine, Marien-Hospital, Niels-Stensen-Kliniken, Osnabrück, Germany.

Address correspondence to: Jerzy-Roch Nofer, Zentrale Einrichtung UKM Labor, Universitätsklinikum Münster, Albert-Schweizer-Campus 1, Geb. A1, 48149 Münster, Germany. Phone: 49.251.83.47228; Email: nofer@uni-muenster.de. Or to: Ralph Burkhardt, Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany. Phone: 49.941.944.6201; Email: Ralph.Burkhardt@klinik.uni-regensburg.de.

Authorship note: FP and ES contributed equally to this work. RB and JRN contributed equally to this work.

Find articles by Hesse, B. in: JCI | PubMed | Google Scholar

1Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, Parma, Italy.

2Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.

3Department of Food and Drug, University of Parma, Parma, Italy.

4Central Laboratory Facility, University Hospital Münster, Münster, Germany.

5Institute of Molecular Tumor Biology, University of Münster, Münster, Germany.

6Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany.

7Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Münster, Münster, Germany.

8Department of Cardiology, University Hospital Münster, Münster, Germany.

9Pharvaris GmbH, Zug, Switzerland.

10Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

11Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.

12Division of General Internal Medicine, Nephrology, and Rheumatology, Department of Medicine D, and

13Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.

14Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

15Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

16Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, Mainz, Germany.

17Department of Clinical Biochemistry, Rigshospitalet, and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

18Institute for Laboratory Medicine, Marien-Hospital, Niels-Stensen-Kliniken, Osnabrück, Germany.

Address correspondence to: Jerzy-Roch Nofer, Zentrale Einrichtung UKM Labor, Universitätsklinikum Münster, Albert-Schweizer-Campus 1, Geb. A1, 48149 Münster, Germany. Phone: 49.251.83.47228; Email: nofer@uni-muenster.de. Or to: Ralph Burkhardt, Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany. Phone: 49.941.944.6201; Email: Ralph.Burkhardt@klinik.uni-regensburg.de.

Authorship note: FP and ES contributed equally to this work. RB and JRN contributed equally to this work.

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1Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, Parma, Italy.

2Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.

3Department of Food and Drug, University of Parma, Parma, Italy.

4Central Laboratory Facility, University Hospital Münster, Münster, Germany.

5Institute of Molecular Tumor Biology, University of Münster, Münster, Germany.

6Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany.

7Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Münster, Münster, Germany.

8Department of Cardiology, University Hospital Münster, Münster, Germany.

9Pharvaris GmbH, Zug, Switzerland.

10Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

11Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.

12Division of General Internal Medicine, Nephrology, and Rheumatology, Department of Medicine D, and

13Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.

14Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

15Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

16Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, Mainz, Germany.

17Department of Clinical Biochemistry, Rigshospitalet, and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

18Institute for Laboratory Medicine, Marien-Hospital, Niels-Stensen-Kliniken, Osnabrück, Germany.

Address correspondence to: Jerzy-Roch Nofer, Zentrale Einrichtung UKM Labor, Universitätsklinikum Münster, Albert-Schweizer-Campus 1, Geb. A1, 48149 Münster, Germany. Phone: 49.251.83.47228; Email: nofer@uni-muenster.de. Or to: Ralph Burkhardt, Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany. Phone: 49.941.944.6201; Email: Ralph.Burkhardt@klinik.uni-regensburg.de.

Authorship note: FP and ES contributed equally to this work. RB and JRN contributed equally to this work.

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1Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, Parma, Italy.

2Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.

3Department of Food and Drug, University of Parma, Parma, Italy.

4Central Laboratory Facility, University Hospital Münster, Münster, Germany.

5Institute of Molecular Tumor Biology, University of Münster, Münster, Germany.

6Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany.

7Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Münster, Münster, Germany.

8Department of Cardiology, University Hospital Münster, Münster, Germany.

9Pharvaris GmbH, Zug, Switzerland.

10Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

11Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.

12Division of General Internal Medicine, Nephrology, and Rheumatology, Department of Medicine D, and

13Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.

14Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

15Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

16Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, Mainz, Germany.

17Department of Clinical Biochemistry, Rigshospitalet, and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

18Institute for Laboratory Medicine, Marien-Hospital, Niels-Stensen-Kliniken, Osnabrück, Germany.

Address correspondence to: Jerzy-Roch Nofer, Zentrale Einrichtung UKM Labor, Universitätsklinikum Münster, Albert-Schweizer-Campus 1, Geb. A1, 48149 Münster, Germany. Phone: 49.251.83.47228; Email: nofer@uni-muenster.de. Or to: Ralph Burkhardt, Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany. Phone: 49.941.944.6201; Email: Ralph.Burkhardt@klinik.uni-regensburg.de.

Authorship note: FP and ES contributed equally to this work. RB and JRN contributed equally to this work.

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1Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, Parma, Italy.

2Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.

3Department of Food and Drug, University of Parma, Parma, Italy.

4Central Laboratory Facility, University Hospital Münster, Münster, Germany.

5Institute of Molecular Tumor Biology, University of Münster, Münster, Germany.

6Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany.

7Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Münster, Münster, Germany.

8Department of Cardiology, University Hospital Münster, Münster, Germany.

9Pharvaris GmbH, Zug, Switzerland.

10Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

11Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.

12Division of General Internal Medicine, Nephrology, and Rheumatology, Department of Medicine D, and

13Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.

14Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

15Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

16Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, Mainz, Germany.

17Department of Clinical Biochemistry, Rigshospitalet, and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

18Institute for Laboratory Medicine, Marien-Hospital, Niels-Stensen-Kliniken, Osnabrück, Germany.

Address correspondence to: Jerzy-Roch Nofer, Zentrale Einrichtung UKM Labor, Universitätsklinikum Münster, Albert-Schweizer-Campus 1, Geb. A1, 48149 Münster, Germany. Phone: 49.251.83.47228; Email: nofer@uni-muenster.de. Or to: Ralph Burkhardt, Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany. Phone: 49.941.944.6201; Email: Ralph.Burkhardt@klinik.uni-regensburg.de.

Authorship note: FP and ES contributed equally to this work. RB and JRN contributed equally to this work.

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1Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, Parma, Italy.

2Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.

3Department of Food and Drug, University of Parma, Parma, Italy.

4Central Laboratory Facility, University Hospital Münster, Münster, Germany.

5Institute of Molecular Tumor Biology, University of Münster, Münster, Germany.

6Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany.

7Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Münster, Münster, Germany.

8Department of Cardiology, University Hospital Münster, Münster, Germany.

9Pharvaris GmbH, Zug, Switzerland.

10Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

11Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.

12Division of General Internal Medicine, Nephrology, and Rheumatology, Department of Medicine D, and

13Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.

14Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

15Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

16Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, Mainz, Germany.

17Department of Clinical Biochemistry, Rigshospitalet, and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

18Institute for Laboratory Medicine, Marien-Hospital, Niels-Stensen-Kliniken, Osnabrück, Germany.

Address correspondence to: Jerzy-Roch Nofer, Zentrale Einrichtung UKM Labor, Universitätsklinikum Münster, Albert-Schweizer-Campus 1, Geb. A1, 48149 Münster, Germany. Phone: 49.251.83.47228; Email: nofer@uni-muenster.de. Or to: Ralph Burkhardt, Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany. Phone: 49.941.944.6201; Email: Ralph.Burkhardt@klinik.uni-regensburg.de.

Authorship note: FP and ES contributed equally to this work. RB and JRN contributed equally to this work.

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