Adriana S. Leme

William J. Janssen

Maria C. Basil

Corrine R. Kliment

Christopher M. Evans

Herbert B. Schiller

European Respiratory Journal 2302071; DOI: 10.1183/13993003.02071-2023 Published 21 November 2024

Emphysema, the progressive destruction of gas exchange surfaces in the lungs, is a hallmark of chronic obstructive pulmonary disease (COPD) that is presently incurable. This therapeutic gap is largely due to a poor understanding of potential drivers of impaired tissue regeneration, such as abnormal lung epithelial progenitor cells, including alveolar type II (ATII) and airway…