Buchbinder, R. et al. Low back pain: a call for action. Lancet 391, 2384–2388 (2018).
Fehlings, M. G. et al. The aging of the global population: the changing epidemiology of disease and spinal disorders. Neurosurgery 77, S1–S5 (2015).
Fine, N. et al. Intervertebral disc degeneration and osteoarthritis: a common molecular disease spectrum. Nat. Rev. Rheumatol. 19, 136–152 (2023).
Hunter, D. J. & Bierma-Zeinstra, S. Osteoarthritis. Lancet 393, 1745–1759 (2019).
Article CAS PubMed Google Scholar
Binch, A. L. A., Fitzgerald, J. C., Growney, E. A. & Barry, F. Cell-based strategies for IVD repair: clinical progress and translational obstacles. Nat. Rev. Rheumatol. 17, 158–175 (2021).
Yang, S., Zhang, F., Ma, J. & Ding, W. Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen. Ageing Res. Rev. 57, 100978 (2020).
Article CAS PubMed Google Scholar
Xiang, Q., Zhao, Y., Lin, J., Jiang, S. & Li, W. The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights. Exp. Mol. Med. 54, 1067–1075 (2022).
Article CAS PubMed PubMed Central Google Scholar
Xiang, Q., Zhao, Y., Lin, J., Jiang, S. & Li, W. Epigenetic modifications in spinal ligament aging. Ageing Res Rev. 77, 101598 (2022).
Sampath, S. J. P., Venkatesan, V., Ghosh, S. & Kotikalapudi, N. Obesity, metabolic syndrome, and osteoarthritis-an updated review. Curr. Obes. Rep. 12, 308–331 (2023).
Fan, D., Chen, Z., Chen, Y. & Shang, Y. Mechanistic roles of leptin in osteogenic stimulation in thoracic ligament flavum cells. J. Biol. Chem. 282, 29958–29966 (2007).
Article CAS PubMed Google Scholar
Francisco, V. et al. A new immunometabolic perspective of intervertebral disc degeneration. Nat. Rev. Rheumatol. 18, 47–60 (2022).
Article CAS PubMed Google Scholar
Segar, A. H. et al. Obesity increases the odds of intervertebral disc herniation and spinal stenosis; an MRI study of 1634 low back pain patients. Eur. Spine J. 33, 915–923 (2024).
Afshin, A. et al. Health effects of overweight and obesity in 195 countries over 25 years. N. Engl. J. Med. 377, 13–27 (2017).
Singh, N. K., Singh, N. K., Verma, R. & Diwan, A. D. Validation and estimation of obesity-induced intervertebral disc degeneration through subject-specific finite element modelling of functional spinal units. Bioengineering 11, 344 (2024).
Chen, L. et al. Pathogenesis and clinical management of obesity-related knee osteoarthritis: Impact of mechanical loading. J. Orthop. Transl. 24, 66–75 (2020).
Lopez-Yus, M., Hörndler, C., Borlan, S., Bernal-Monterde, V. & Arbones-Mainar, J. M. Unraveling adipose tissue dysfunction: molecular mechanisms, novel biomarkers, and therapeutic targets for liver fat deposition. Cells 13, 5 (2024).
Nussbaumerova, B. & Rosolova, H. Obesity and dyslipidemia. Curr. Atheroscler. Rep. 25, 947–955 (2023).
Article CAS PubMed Google Scholar
He, Y. et al. Roles of organokines in intervertebral disc homeostasis and degeneration. Front. Endocrinol. 15, 1340625 (2024).
Sampara, P., Banala, R. R., Vemuri, S. K., Av, G. R. & Gpv, S. Understanding the molecular biology of intervertebral disc degeneration and potential gene therapy strategies for regeneration: a review. Gene Ther. 25, 67–82 (2018).
Article CAS PubMed Google Scholar
Lyu, F. J. et al. Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions. Bone Res. 9, 7 (2021).
Article CAS PubMed PubMed Central Google Scholar
Sakai, D. & Grad, S. Advancing the cellular and molecular therapy for intervertebral disc disease. Adv. Drug Deliv. Rev. 84, 159–171 (2015).
Article CAS PubMed Google Scholar
Liu, J. et al. Identification of CXCL16 as a diagnostic biomarker for obesity and intervertebral disc degeneration based on machine learning. Sci. Rep. 13, 21316 (2023).
Article CAS PubMed PubMed Central Google Scholar
Ambrosio, L. et al. The burden of low back pain in children and adolescents with overweight and obesity: from pathophysiology to prevention and treatment strategies. Ther. Adv. Musculoskelet. Disease 15, 1759720X231188831 (2023).
Ranson, W. A. et al. Risk factors for perioperative complications in morbidly obese patients undergoing elective posterior lumbar fusion. Glob. Spine J. 8, 795–802 (2018).
Lener, S., Wipplinger, C., Hartmann, S., Thomé, C. & Tschugg, A. The impact of obesity and smoking on young individuals suffering from lumbar disc herniation: a retrospective analysis of 97 cases. Neurosurg. Rev. 43, 1297–1303 (2020).
Coppock, J. A. et al. Increasing BMI increases lumbar intervertebral disc deformation following a treadmill walking stress test. J. Biomech. 121, 110392 (2021).
Article PubMed PubMed Central Google Scholar
Adams, M. A. & Roughley, P.J. What is intervertebral disc degeneration, and what causes it? Spine 31, 2151–2161 (2006).
Wilke, H. J., Neef, P., Caimi, M., Hoogland, T. & Claes, L. E. New in vivo measurements of pressures in the intervertebral disc in daily life. Spine 24, 755–762 (1999).
Article CAS PubMed Google Scholar
Yan, Z. et al. Static compression induces ECM remodeling and integrin α2β1 expression and signaling in a rat tail caudal intervertebral disc degeneration model. Spine 42, E448–e458, (2017).
Xiang, Q. et al. CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis. EBioMedicine 53, 102679 (2020).
Article PubMed PubMed Central Google Scholar
Ariga, K. et al. Mechanical stress-induced apoptosis of endplate chondrocytes in organ-cultured mouse intervertebral discs: an ex vivo study. Spine 28, 1528–1533 (2003).
Xu, H. G. et al. Intermittent cyclic mechanical tension promotes endplate cartilage degeneration via canonical Wnt signaling pathway and E-cadherin/β-catenin complex cross-talk. Osteoarthr. Cartil. 24, 158–168 (2016).
Wang, Z. et al. Mechanical factors regulate annulus fibrosus (AF) injury repair and remodeling: a review. ACS Biomater. Sci. Eng. 10, 219–233 (2024).
Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425–432 (1994).
Article CAS PubMed Google Scholar
Zhao, C. Q., Liu, D., Li, H., Jiang, L. S. & Dai, L. Y. Expression of leptin and its functional receptor on disc cells: contribution to cell proliferation. Spine 33, E858–864, (2008).
Miao, D. & Zhang, L. Leptin modulates the expression of catabolic genes in rat nucleus pulposus cells through the mitogen-activated protein kinase and Janus kinase 2/signal transducer and activator of transcription 3 pathways. Mol. Med. Rep. 12, 1761–1768 (2015).
Article CAS PubMed PubMed Central Google Scholar
Ding, W. et al. Leptin induces terminal differentiation of rat annulus fibrosus cells via activation of MAPK signaling. Anat. Rec. 296, 1806–1812 (2013).
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