The interplay between mitochondrial dynamics and autophagy: From a key homeostatic mechanism to a driver of pathology

ADOA

Autosomal dominant optic atrophy

AMBRA1

Autophagy/BECN1regulator-1

AMPK

AMP-activated protein kinase

ARIH1

Ariadne RBR E3 ubiquitin protein ligase 1

ATAT1

alpha-tubulin N-acetyltransferase 1

BNIP3

BCL2/adenovirus E1B 19 kDa interacting protein 3

CaMKII

Calcium/calmodulin-dependent protein kinase II

CCCP

Carbonyl cyanide m-chlorophenyl hydrazone

CMA

Chaperone-mediated autophagy

CMT2A

Charcot–Marie–Tooth type 2A

DRP1

Dynamin-related protein 1

ESCRT

Endosomal sorting complexes required for transport

FCCP

Carbonyl cyanide-p-trifluoromethoxyphenylhydrazone

FIP200

Focal adhesion kinase family-interacting protein of 200 kDa

FKBP8

FK506-binding protein 8

FUNDC1

FUN14 domain contains 1

GABARAP

Gamma-aminobutyric acid receptor-associated protein

IMM

Inner mitochondrial membrane

LAMP2A

Lysosomal membrane protein 2A

LIR

LC3-interacting region

MAM

Mitochondrial-associated ER membrane

MAO-B

Monoamine Oxidase Type B

MAPL

Mitochondrial-anchored protein ligase

MCL-1

Myeloid cell leukemia-1

MERC

Mitochondrion-ER contact

MFF

Mitochondrial fission factor

MIRO

Mitochondrial Rho GTPase

MPP

Mitochondrial-processing protease

mTORC1

Mechanistic target of rapamycin complex 1 kinase

MUL1

Mitochondrial E3 ubiquitin protein ligase 1

NDP52

Nuclear dot protein 52

OMA1

Metalloproteases M-AAA protease 1

OMM

Outer mitochondrial membrane

PARL

Presenilin-associated rhomboid-like

PE

Phosphatidylethanolamine

PGAM5

PGAM family member 5

PI3K

Phosphoinositide 3-kinases

PI3P

Phosphatidylinositol-3-phosphate

PINK1

PTEN-induced kinase 1

PPARγ

Peroxisome proliferator activated receptor γ

PTM

Post-translational modification

SIAH1

Seven in absentia homolog 1

SNARE

Soluble N-ethylmaleimide-sensitive factor attachment protein receptor

TAX1BP1

Tax1-binding protein 1

TIM

Translocase of the inner mitochondrial membrane

TOM

Translocase of the outer membrane

TRAK

Trafficking Kinesin Protein

UBE2E3

Ubiquitin-conjugating enzyme E2 E3

VDAC1

Voltage-dependent anion channel 1

VPS

Vacuolar protein sorting protein

ΔΨm

Mitochondrial membrane potential

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