Kufe DW. Mucins in cancer: function, prognosis and therapy. Nat Rev Cancer. 2009;9(12):874–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kufe D, Inghirami G, Abe M, Hayes D, Justi-Wheeler H, Schlom J. Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors. Hybridoma. 1984;3(3):223–32.

Article  CAS  PubMed  Google Scholar 

Ormerod MG, Steele K, Edwards PA, Taylor-Papadimitriou J. Monoclonal antibodies that react with epithelial membrane antigen. J Exp Pathol. 1984;1(4):263–71.

CAS  PubMed  Google Scholar 

Kufe DW. MUC1-C in chronic inflammation and carcinogenesis; emergence as a target for cancer treatment. Carcinogenesis. 2020;41(9):1173–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ukkonen H, Pirhonen P, Herrala M, Mikkonen JJ, Singh SP, Sormunen R, et al. Oral mucosal epithelial cells express the membrane anchored mucin MUC1. Arch Oral Biol. 2017;73:269–73.

Article  CAS  PubMed  Google Scholar 

Mather IH, Jack LJ, Madara PJ, Johnson VG. The distribution of MUC1, an apical membrane glycoprotein, in mammary epithelial cells at the resolution of the electron microscope: implications for the mechanism of milk secretion. Cell Tissue Res. 2001;304(1):91–101.

Article  CAS  PubMed  Google Scholar 

Ilkovitch D, Carrio R, Lopez DM. Mechanisms of antitumor and immune-enhancing activities of MUC1/sec, a secreted form of mucin-1. Immunol Res. 2013;57(1–3):70–80.

Article  CAS  PubMed  Google Scholar 

Scholfield DP, Simms MS, Bishop MC. MUC1 mucin in urological malignancy. BJU Int. 2003;91(6):560–6.

Article  CAS  PubMed  Google Scholar 

Jin W, Zhang M, Dong C, Huang L, Luo Q. The multifaceted role of MUC1 in tumor therapy resistance. Clin Exp Med. 2023;23(5):1441–74.

Article  CAS  PubMed  Google Scholar 

Beckwith DM, Cudic M. Tumor-associated O-glycans of MUC1: carriers of the glyco-code and targets for cancer vaccine design. Semin Immunol. 2020;47: 101389.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duraisamy S, Kufe T, Ramasamy S, Kufe D. Evolution of the human MUC1 oncoprotein. Int J Oncol. 2007;31(3):671–7.

CAS  PubMed  Google Scholar 

Duraisamy S, Ramasamy S, Kharbanda S, Kufe D. Distinct evolution of the human carcinoma-associated transmembrane mucins, MUC1, MUC4 AND MUC16. Gene. 2006;373:28–34.

Article  CAS  PubMed  Google Scholar 

Li W, Han Y, Sun C, Li X, Zheng J, Che J, et al. Novel insights into the roles and therapeutic implications of MUC1 oncoprotein via regulating proteins and non-coding RNAs in cancer. Theranostics. 2022;12(3):999–1011.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Apostolopoulos V, Stojanovska L, Gargosky SE. MUC1 (CD227): a multi-tasked molecule. Cell Mol Life Sci. 2015;72(23):4475–500.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Julian J, Dharmaraj N, Carson DD. MUC1 is a substrate for gamma-secretase. J Cell Biochem. 2009;108(4):802–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shurer CR, Kuo JC, Roberts LM, Gandhi JG, Colville MJ, Enoki TA, et al. Physical principles of membrane shape regulation by the glycocalyx. Cell. 2019;177(7):1757-70 e21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang L, Gallup M, Zlock L, Chen YT, Finkbeiner WE, McNamara NA. Pivotal role of MUC1 glycosylation by cigarette smoke in modulating disruption of airway adherens junctions in vitro. J Pathol. 2014;234(1):60–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Raina D, Ahmad R, Rajabi H, Panchamoorthy G, Kharbanda S, Kufe D. Targeting cysteine-mediated dimerization of the MUC1-C oncoprotein in human cancer cells. Int J Oncol. 2012;40(5):1643–9.

CAS  PubMed  Google Scholar 

Hashash JG, Beatty PL, Critelli K, Hartman DJ, Regueiro M, Tamim H, et al. Altered expression of the epithelial mucin MUC1 accompanies endoscopic recurrence of postoperative Crohn’s disease. J Clin Gastroenterol. 2021;55(2):127–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nath S, Mukherjee P. MUC1: a multifaceted oncoprotein with a key role in cancer progression. Trends Mol Med. 2014;20(6):332–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu G, Kim D, Kim JN, Park S, Maharjan S, Koh H, et al. A mucin1 C-terminal subunit-directed monoclonal antibody targets overexpressed mucin1 in breast cancer. Theranostics. 2018;8(1):78–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yamashita N, Kufe D. Addiction of cancer stem cells to muc1-c in triple-negative breast cancer progression. Int J Mol Sci. 2022;23(15):8219.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haratake N, Ozawa H, Morimoto Y, Yamashita N, Daimon T, Bhattacharya A, et al. MUC1-C is a common driver of acquired osimertinib resistance in NSCLC. J Thorac Oncol. 2023. https://doi.org/10.1158/1535-7163.TARG-23-B089.

Article  PubMed  Google Scholar 

Yamamoto M, Jin C, Hata T, Yasumizu Y, Zhang Y, Hong D, et al. MUC1-C integrates chromatin remodeling and PARP1 activity in the dna damage response of triple-negative breast cancer cells. Cancer Res. 2019;79(8):2031–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McAuley JL, Linden SK, Png CW, King RM, Pennington HL, Gendler SJ, et al. MUC1 cell surface mucin is a critical element of the mucosal barrier to infection. J Clin Invest. 2007;117(8):2313–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Corfield AP. Mucins: a biologically relevant glycan barrier in mucosal protection. Biochim Biophys Acta. 2015;1850(1):236–52.

Article  CAS  PubMed  Google Scholar 

Song X, Airan RD, Arifin DR, Bar-Shir A, Kadayakkara DK, Liu G, et al. Label-free in vivo molecular imaging of underglycosylated mucin-1 expression in tumour cells. Nat Commun. 2015;6:6719.

Article  CAS  PubMed  Google Scholar 

Ramasamy S, Duraisamy S, Barbashov S, Kawano T, Kharbanda S, Kufe D. The MUC1 and galectin-3 oncoproteins function in a microRNA-dependent regulatory loop. Mol Cell. 2007;27(6):992–1004.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Geraci C, Consoli GM, Granata G, Galante E, Palmigiano A, Pappalardo M, et al. First self-adjuvant multicomponent potential vaccine candidates by tethering of four or eight MUC1 antigenic immunodominant PDTRP units on a calixarene platform: synthesis and biological evaluation. Bioconjug Chem. 2013;24(10):1710–20.

Article  CAS  PubMed  Google Scholar 

Huang ZH, Shi L, Ma JW, Sun ZY, Cai H, Chen YX, et al. A totally synthetic