Iynedjian PB. Molecular physiology of mammalian glucokinase. Cell Mol Life Sci. 2009;66(1):27–42.

Article  CAS  PubMed  Google Scholar 

Matschinsky FM, Magnuson MA, Zelent D, Jetton TL, Doliba N, Han Y, et al. The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy. Diabetes. 2006;55(1):1–12.

Article  CAS  PubMed  Google Scholar 

Matschinsky FM, Wilson DF. The central role of glucokinase in glucose homeostasis: a perspective 50 years after demonstrating the presence of the enzyme in islets of langerhans. Front Physiol. 2019;10:148.

Article  PubMed  PubMed Central  Google Scholar 

Matschinsky FM, Ellerman JE. Metabolism of glucose in the islets of Langerhans. J Biol Chem. 1968;243(10):2730–6.

Article  CAS  PubMed  Google Scholar 

Salas M, Vinuela E, Sols A. Insulin-dependent synthesis of liver glucokinase in the rat. J Biol Chem. 1963;238:3535–8.

Article  CAS  PubMed  Google Scholar 

Hattersley AT, Turner RC, Permutt MA, Patel P, Tanizawa Y, Chiu KC, et al. Linkage of type 2 diabetes to the glucokinase gene. Lancet. 1992;339(8805):1307–10.

Article  CAS  PubMed  Google Scholar 

Njolstad PR, Sovik O, Cuesta-Munoz A, Bjorkhaug L, Massa O, Barbetti F, et al. Neonatal diabetes mellitus due to complete glucokinase deficiency. N Engl J Med. 2001;344(21):1588–92.

Article  CAS  PubMed  Google Scholar 

Sternisha SM, Miller BG. Molecular and cellular regulation of human glucokinase. Arch Biochem Biophys. 2019;663:199–213.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Osbak KK, Colclough K, Saint-Martin C, Beer NL, Bellanne-Chantelot C, Ellard S, et al. Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia. Hum Mutat. 2009;30(11):1512–26.

Article  CAS  PubMed  Google Scholar 

Capuano M, Garcia-Herrero CM, Tinto N, Carluccio C, Capobianco V, Coto I, et al. Glucokinase (GCK) mutations and their characterization in MODY2 children of southern Italy. PLoS ONE. 2012;7(6): e38906.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lopez AP, de Dios A, Chiesa I, Perez MS, Frechtel GD. Analysis of mutations in the glucokinase gene in people clinically characterized as MODY2 without a family history of diabetes. Diabetes Res Clin Pract. 2016;118:38–43.

Article  CAS  PubMed  Google Scholar 

Shoemaker AH, Zienkiewicz J, Moore DJ. Clinical assessment of HNF1A and GCK variants and identification of a novel mutation causing MODY2. Diabetes Res Clin Pract. 2012;96(2):e36–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jetton TL, Liang Y, Pettepher CC, Zimmerman EC, Cox FG, Horvath K, et al. Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut. J Biol Chem. 1994;269(5):3641–54.

Article  CAS  PubMed  Google Scholar 

Agius L. Hormonal and metabolite regulation of hepatic glucokinase. Annu Rev Nutr. 2016;36:389–415.

Article  CAS  PubMed  Google Scholar 

Kamata K, Mitsuya M, Nishimura T, Eiki J, Nagata Y. Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase. Structure. 2004;12(3):429–38.

Article  CAS  PubMed  Google Scholar 

Andreone TL, Printz RL, Pilkis SJ, Magnuson MA, Granner DK. The amino acid sequence of rat liver glucokinase deduced from cloned cDNA. J Biol Chem. 1989;264(1):363–9.

Article  CAS  PubMed  Google Scholar 

Aleshin AE, Zeng C, Bartunik HD, Fromm HJ, Honzatko RB. Regulation of hexokinase I: crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate. J Mol Biol. 1998;282(2):345–57.

Article  CAS  PubMed  Google Scholar 

Mitsuya M, Kamata K, Bamba M, Watanabe H, Sasaki Y, Sasaki K, et al. Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators. Bioorg Med Chem Lett. 2009;19(10):2718–21.

Article  CAS  PubMed  Google Scholar 

Takahashi K, Hashimoto N, Nakama C, Kamata K, Sasaki K, Yoshimoto R, et al. The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators. Bioorg Med Chem. 2009;17(19):7042–51.

Article  CAS  PubMed  Google Scholar 

Bebernitz GR, Beaulieu V, Dale BA, Deacon R, Duttaroy A, Gao J, et al. Investigation of functionally liver selective glucokinase activators for the treatment of type 2 diabetes. J Med Chem. 2009;52(19):6142–52.

Article  CAS  PubMed  Google Scholar 

Petit P, Antoine M, Ferry G, Boutin JA, Lagarde A, Gluais L, et al. The active conformation of human glucokinase is not altered by allosteric activators. Acta Crystallogr D Biol Crystallogr. 2011;67(Pt 11):929–35.

Article  CAS  PubMed  Google Scholar 

Zhang J, Li C, Shi T, Chen K, Shen X, Jiang H. Lys169 of human glucokinase is a determinant for glucose phosphorylation: implication for the atomic mechanism of glucokinase catalysis. PLoS ONE. 2009;4(7): e6304.

Article  PubMed  PubMed Central  Google Scholar 

Antoine M, Boutin JA, Ferry G. Binding kinetics of glucose and allosteric activators to human glucokinase reveal multiple conformational states. Biochemistry. 2009;48(23):5466–82.

Article  CAS  PubMed  Google Scholar 

Liu S, Ammirati MJ, Song X, Knafels JD, Zhang J, Greasley SE, et al. Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations. J Biol Chem. 2012;287(17):13598–610.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi JM, Seo MH, Kyeong HH, Kim E, Kim HS. Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase. Proc Natl Acad Sci U S A. 2013;110(25):10171–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Futamura M, Hosaka H, Kadotani A, Shimazaki H, Sasaki K, Ohyama S, et al. An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism. J Biol Chem. 2006;281(49):37668–74.

Article  CAS  PubMed  Google Scholar 

Anderka O, Boyken J, Aschenbach U, Batzer A, Boscheinen O, Schmoll D. Biophysical characterization of the interaction between hepatic glucokinase and its regulatory protein: impact of physiological and pharmacological effectors. J Biol Chem. 2008;283(46):31333–40.

Article  CAS  PubMed  Google Scholar 

Beck T, Miller BG. Structural basis for regulation of human glucokinase by glucokinase regulatory protein. Biochemistry. 2013;52(36):6232–9.

Article  CAS  PubMed  Google Scholar 

Bosco D, Meda P, Iynedjian PB. Glucokinase and glucokinase regulatory protein: mutual dependence for nuclear localization. Biochem J. 2000;348(Pt 1):215–22.

Article  CAS  PubMed  PubMed Central