De Duve C, Wattiaux R. Functions of lysosomes. Annu Rev Physiol. 1966;28:435–92.
De Duve C, Pressman BC, Gianetto R, Wattiaux R, Applemans F. Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue. Biochem J. 1955;60(4):604–17. https://doi.org/10.1042/bj0600604.
Article PubMed PubMed Central Google Scholar
Seglen PO, Gordon PBHI. Non-selective autophagy. Semin Cell Biol. 1990;1(6):441–8.
Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell. 2010;141(2):290–303.
Article CAS PubMed PubMed Central Google Scholar
Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H±ATPase. Science. 2011;334(6056):678–83.
Article CAS PubMed PubMed Central Google Scholar
Gray MA, Choy CH, Dayam RM, Escobar EO, Somerville A, Xiao X, et al. Phagocytosis enhances lysosomal and bactericidal properties by activating the transcription factor TFEB Matthew. Curr Biol. 2017;26(15):1955–64.
Reddy A, Caler EV, Andrews NW, Haven N. Plasma membrane repair is mediated by Ca 2 ± regulated exocytosis of lysosomes. Cell. 2001;106:157–69.
Article CAS PubMed Google Scholar
Encarnação M, Espada L, Escrevente C, Mateus D, Ramalho J, Michelet X, et al. A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair. J Cell Biol. 2016. https://doi.org/10.1083/jcb.201511093.
Article PubMed PubMed Central Google Scholar
Lim CY, Zoncu R. The lysosome as a command-and-control center for cellular metabolism. J Cell Biol. 2016;214(6):653–64.
Article CAS PubMed PubMed Central Google Scholar
Lawrence RE, Zoncu R. The lysosome as a cellular centre for signalling, metabolism and quality control. Nat Cell Biol. 2019;21(2):133–42.
Article CAS PubMed Google Scholar
Repnik U, Česen MH, Turk B. The endolysosomal system in cell death and survival. Cold Spring Harb Perspect Biol. 2013;5(1): a008755.
Article PubMed PubMed Central Google Scholar
Sun A. Lysosomal storage disease overview. Ann Transl Med. 2018. https://doi.org/10.21037/atm.2018.11.39.
Article PubMed PubMed Central Google Scholar
Parenti G, Andria G, Ballabio A. Lysosomal storage diseases : from pathophysiology to therapy. Annu Rev Med. 2015. https://doi.org/10.1146/annurev-med-122313-085916.
Marques ARA, Saftig P. Lysosomal storage disorders—challenges, concepts and avenues for therapy: beyond rare diseases. J Cell Sci. 2019. https://doi.org/10.1242/jcs.221739.
Kirkegaard T, Jäättelä M. Biochimica et biophysica acta lysosomal involvement in cell death and cancer. BBA Mol Cell Res. 2009;1793(4):746–54.
Davidson SM, Vander HMG. Critical functions of the lysosome in cancer biology. Annu Rev Pharmacol Toxicol. 2017;57:481–510.
Article CAS PubMed Google Scholar
Herbst S, Campbell P, Harvey J, Bernard EM, Papayannopoulos V, Wood NW, et al. LRRK 2 activation controls the repair of damaged endomembranes in macrophages. EMBO J. 2020;39(18):1–14.
Feng T, Mai S, Roscoe JM, Sheng RR, Ullah M, Zhang J, et al. Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice. EMBO Rep. 2020;21(10): e50219.
Article CAS PubMed PubMed Central Google Scholar
Tedeschi V, Petrozziello T, Secondo A. Calcium dyshomeostasis and lysosomal Ca2+ dysfunction in amyotrophic lateral sclerosis. Cells. 2019. https://doi.org/10.3390/cells8101216.
Article PubMed PubMed Central Google Scholar
Cortes CJ, La Spada AR. TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: molecular mechanisms, cellular processes, and emerging therapeutic opportunities. Neurobiol Dis. 2018. https://doi.org/10.1016/j.nbd.2018.05.012.
Article PubMed PubMed Central Google Scholar
Wang Y, Martinez-Vicente M, Krüger U, Kaushik S, Wong E, Mandelkow EM, et al. Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. Hum Mol Genet. 2009;18(21):4153–70.
Article CAS PubMed PubMed Central Google Scholar
Dodson MW, Zhang T, Jiang C, Chen S, Guo M. Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning. Hum Mol Genet. 2012;21(6):1350–63.
Article CAS PubMed Google Scholar
Tohnai G, Adachi H, Katsuno M, Doi H, Matsumoto S, Kondo N, et al. Paeoniflorin eliminates a mutant AR via NF-YA-dependent proteolysis in spinal and bulbar muscular atrophy. Hum Mol Genet. 2014. https://doi.org/10.1093/hmg/ddu066.
Mathis S, Goizet C, Soulages A, Vallat JM, Le MG. Genetics of amyotrophic lateral sclerosis: a review. J Neurol Sci. 2019;399(February):217–26.
Article CAS PubMed Google Scholar
Carmona-gutierrez D, Hughes AL, Madeo F, Ruckenstuhl C. The crucial impact of lysosomes in aging and longevity. Age Res Rev. 2016;32:2–12.
Peters C, von Figura K. Biogenesis of lysosomal membranes. FEBS Lett. 1994;346(1):108–14.
Article CAS PubMed Google Scholar
Schwake M, Schröder B, Saftig P. Lysosomal membrane proteins and their central role in physiology. Traffic. 2013;14(7):739–48.
Article CAS PubMed Google Scholar
Schröder B, Wrocklage C, Pan C, Jäger R, Kösters B, Schäfer H, et al. Integral and associated lysosomal membrane proteins. Traffic. 2007;8(12):1676–86.
Schröder BA, Wrocklage C, Hasilik A, Saftig P. The proteome of lysosomes. Proteomics. 2010;10(22):4053–76.
Lewis V, Green SA, Marsh M, Vlhko P, Helenius A, Mellman I. Glycoproteins of the lysosomal membrane. J Cell Biol. 1985;100(6):1839–47.
Article CAS PubMed Google Scholar
Andrejewski N, Punnonen EL, Guhde G, Tanaka Y, Lüllmann-Rauch R, Hartmann D, et al. Normal lysosomal morphology and function in LAMP-1-deficient mice. J Biol Chem. 1999;274(18):12692–701.
Article CAS PubMed Google Scholar
Tanaka Y, Guhde G, Suter A, Eskelinen EL, Hartmann D, Lüllmann-Rauch R, et al. Accumulation of autophagic vacuoles and cardiomyopathy LAMP-2-deficient mice. Nature. 2000;406(6798):902–6.
留言 (0)