Akdis M, Burgler S, Crameri R, Eiwegger T, Fujita H, Gomez E, Klunker S, Meyer N, O’Mahony L, Palomares O, Rhyner C, Ouaked N, Schaffartzik A, Van De Veen W, Zeller S, Zimmermann M, Akdis CA (2011) Interleukins from 1 to 37 and interferon γ receptors functions and roles in diseases. J Allergy Clin Immunol 127(3):701-721.e70. https://doi.org/10.1016/j.jaci.2010.11.050

Article  CAS  PubMed  Google Scholar 

Alam R, Stafford S, Forsythe P, Harrison R, Faubion D, Lett-Brown MA, Grant JA (1993) Rantes is a chemotactic and activating factor for human eosinophils. J Immunol 150(8):3442–3448

Article  CAS  PubMed  Google Scholar 

Appelboom T, Schuermans J, Verbruggen G, Henrotin Y, Reginster JY (2001) Symptoms modifying effect of avocado/soybean unsaponifiables (Asu) in knee osteoarthritis. a double-blind, prospective, placebo-controlled study. Scand J Rheumatol 30(4):242–247. https://doi.org/10.1080/030097401316909602

Article  CAS  PubMed  Google Scholar 

Au RY, Al-Talib TK, Au AY, Phan PV, Frondoza CG (2007) Avocado soybean unsaponifiables (Asu) suppress tnf-alpha, Il-1beta, cox-2, Inos gene expression, and prostaglandin e2 and nitric oxide production in articular chondrocytes and monocyte/macrophages. Osteoarthritis Cartilage 15(11):1249–1255. https://doi.org/10.1016/j.joca.2007.07.009

Article  CAS  PubMed  Google Scholar 

Bischoff SC, Krieger M, Brunner T, Rot A, von Tscharner V, Baggiolini M, Dahinden CA (1993) Rantes and related chemokines activate human basophil granulocytes through different G protein-coupled receptors. Eur J Immunol 23(3):761–767. https://doi.org/10.1002/eji.1830230329

Article  CAS  PubMed  Google Scholar 

Blotman F, Maheu E, Wulwik A, Caspard H, Lopez A (1997) Efficacy and safety of avocado/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip. A prospective, multicenter, three-month, randomized, double-blind, placebo-controlled trial. Rev Rhum Engl Ed 64(12):825–834

CAS  PubMed  Google Scholar 

Chatterjee P, Chiasson VL, Bounds KR, Mitchell BM (2014) Regulation of the anti-inflammatory cytokines interleukin-4 and interleukin-10 during pregnancy. Front Immunol 5:253. https://doi.org/10.3389/fimmu.2014.00253

Article  CAS  PubMed  PubMed Central  Google Scholar 

Christiansen BA, Bhatti S, Goudarzi R, Emami S (2016) Erratum: response to the letter to the editor for “Management of osteoarthritis with avocado/soybean unsaponifiables.” Cartilage 7(1):114–115. https://doi.org/10.1177/1947603515623157

Article  PubMed  PubMed Central  Google Scholar 

Dell’Isola A, Turkiewicz A, Zhang W, Kiadaliri A, Bierma-Zeinstra S, Runhaar J, Prieto-Alhambra D, Englund M (2022) Does osteoarthritis modify the association between nsaid use and risk of comorbidities and adverse events? Osteoarthr Cartil Open 4(2):100253. https://doi.org/10.1016/j.ocarto.2022.100253

Article  PubMed  PubMed Central  Google Scholar 

DiNubile NA (2010) A potential role for avocado- and soybean-based nutritional supplements in the management of osteoarthritis: a review. Phys Sportsmed 38(2):71–81. https://doi.org/10.3810/psm.2010.06.1785

Article  PubMed  Google Scholar 

Ernst E (2003) Avocado-soybean unsaponifiables (Asu) for osteoarthritis - a systematic review. Clin Rheumatol 22(4–5):285–288. https://doi.org/10.1007/s10067-003-0731-4

Article  CAS  PubMed  Google Scholar 

Frondoza CG, Fortuno LV, Grzanna MW, Ownby SL, Au AY, Rashmir-Raven AM (2018) Α-lipoic acid potentiates the anti-inflammatory activity of avocado/soybean unsaponifiables in chondrocyte cultures. Cartilage 9(3):304–312. https://doi.org/10.1177/1947603516686146

Article  CAS  PubMed  Google Scholar 

Gabay O, Gosset M, Levy A, Salvat C, Sanchez C, Pigenet A, Sautet A, Jacques C, Berenbaum F (2008) Stress-induced signaling pathways in hyalin chondrocytes: inhibition by avocado-soybean unsaponifiables (Asu). Osteoarthritis Cartilage 16(3):373–384. https://doi.org/10.1016/j.joca.2007.06.016

Article  CAS  PubMed  Google Scholar 

Głuszko P, Stasiek M (2016) Symptom-modifying effects of oral avocado/soybean unsaponifiables in routine treatment of knee osteoarthritis in poland. an open, prospective observational study of patients adherent to a 6-month treatment. Reumatologia 54(5):217–226. https://doi.org/10.5114/reum.2016.63661

Article  PubMed  PubMed Central  Google Scholar 

Goudarzi R, Taylor JF, Yazdi PG, Pedersen BA (2017) Effects of arthrocen, an avocado/soy unsaponifiables agent, on inflammatory mediators and gene expression in human chondrocytes. FEBS Open Bio 7(2):187–194. https://doi.org/10.1002/2211-5463.12176

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goudarzi R, Reid A, McDougall JJ (2018) Evaluation of the novel avocado/soybean unsaponifiable arthrocen to alter joint pain and inflammation in a rat model of osteoarthritis. PLoS ONE 13(2):e0191906. https://doi.org/10.1371/journal.pone.0191906

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goudarzi R, Thomas P, Ryan S (2022) Joint dysfunctionality alleviation along with systemic inflammation reduction following arthrocen treatment in patients with knee osteoarthritis a randomized double-blind placebo-controlled clinical trial. Medicina (kaunas) 58(2):228. https://doi.org/10.3390/medicina58020228

Article  PubMed  Google Scholar 

Gregson CL, Armstrong DJ, Bowden J, Cooper C, Edwards J, Gittoes NJL, Harvey N, Kanis J, Leyland S, Low R, McCloskey E, Moss K, Parker J, Paskins Z, Poole K, Reid DM, Stone M, Thomson J, Vine N, Compston J (2022) UK clinical guideline for the prevention and treatment of osteoporosis. Arch Osteoporos 17(1):58. https://doi.org/10.1007/s11657-022-01061-5

Article  PubMed  PubMed Central  Google Scholar 

Grzanna MW, Secor EJ, Fortuno LV, Au AY, Frondoza CG (2020) Anti-Inflammatory effect of carprofen is enhanced by avocado/soybean unsaponifiables, glucosamine and chondroitin sulfate combination in chondrocyte microcarrier spinner culture. Cartilage 11(1):108–116. https://doi.org/10.1177/1947603518783495

Article  CAS  PubMed  Google Scholar 

Gulen MF, Kang Z, Bulek K, Youzhong W, Kim TW, Chen Y, Altuntas CZ, Sass Bak-Jensen K, McGeachy MJ, Do JS, Xiao H, Delgoffe GM, Min B, Powell JD, Tuohy VK, Cua DJ, Li X (2010) The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin 1 receptor pathway and mtor kinase activation. Immunity 32(1):54–66. https://doi.org/10.1016/j.immuni.2009.12.003

Article  CAS  PubMed  PubMed Central  Google Scholar 

Henrotin Y, Mobasheri A (2018) Natural products for promoting joint health and managing osteoarthritis. Curr Rheumatol Rep 20(11):72. https://doi.org/10.1007/s11926-018-0782-9

Article  PubMed  Google Scholar 

Henrotin YE, Deberg MA, Crielaard JM, Piccardi N, Msika P, Sanchez C (2006) Avocado/soybean unsaponifiables prevent the inhibitory effect of osteoarthritic subchondral osteoblasts on aggrecan and type Ii collagen synthesis by chondrocytes. J Rheumatol 33(8):1668–1678

PubMed  Google Scholar 

Henrotin Y, Chevalier X, Deberg M, Balblanc JC, Richette P, Mulleman D, Maillet B, Rannou F, Piroth C, Mathieu P, Conrozier T (2013) Early decrease of serum biomarkers of type ii collagen degradation (Coll2-1) and joint inflammation (Coll2-1 No2 ) by hyaluronic acid intra-articular injections in patients with knee osteoarthritis: a research study part of the biovisco study. J Orthop Res 31(6):901–907. https://doi.org/10.1002/jor.22297

Article  CAS  PubMed  Google Scholar 

Hermann W, Lambova S, Muller-Ladner U (2018) Current treatment options for osteoarthritis. Curr Rheumatol Rev 14(2):108–116. https://doi.org/10.2174/1573397113666170829155149

Article  CAS  PubMed  Google Scholar 

Hunter DJ, Bierma-Zeinstra S (2019) Osteoarthritis. Lancet 393(10182):1745–1759. https://doi.org/10.1016/s0140-6736(19)30417-9

Article  CAS  PubMed  Google Scholar 

James SL, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, Briggs AM (2018) Global, regional and national incidence prevalence and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017 a systematic analysis for the global burden of disease study 2017. Lancet 392(10159):1789–1858. https://doi.org/10.1016/s0140-6736(18)32279-7

Article  Google Scholar 

Jansen NW, Roosendaal G, Hooiveld MJ, Bijlsma JW, van Roon JA, Theobald M, Lafeber FP (2008) Interleukin-10 protects against blood-induced joint damage. Br J Haematol 142(6):953–961. https://doi.org/10.1111/j.1365-2141.2008.07278.x