Abdallah HM, El-halawany AM, Sirwi A et al (2021) Repurposing of some natural product isolates as SARS-COV-2 main protease inhibitors via in vitro cell free and cell-based antiviral assessments and molecular modeling approaches. Pharmaceuticals 14:213. https://doi.org/10.3390/ph14030213

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abian O, Ortega-Alarcon D, Jimenez-Alesanco A et al (2020) Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening. Int J Biol Macromol 164:1693–1703. https://doi.org/10.1016/j.ijbiomac.2020.07.235

Article  CAS  PubMed  PubMed Central  Google Scholar 

Agarwal A, Hunt B, Stegemann M et al (2020) A living WHO guideline on drugs for covid-19. BMJ 370:m3379. https://doi.org/10.1136/bmj.m3379

Article  PubMed  Google Scholar 

Al-Ani B, Shamseldeen AM, Kamar SS et al (2022) Lipopolysaccharide induces acute lung injury and alveolar haemorrhage in association with the cytokine storm, coagulopathy and AT1R/JAK/STAT augmentation in a rat model that mimics moderate and severe Covid-19 pathology. Clin Exp Pharmacol Physiol 49:483–491. https://doi.org/10.1111/1440-1681.13620

Article  CAS  PubMed  Google Scholar 

Aldea M, Michot J, Danlos F et al (2021) Repurposing of anticancer drugs expands possibilities for antiviral and anti-inflammatory discovery in COVID-19. Cancer Discov 11:1336–1344. https://doi.org/10.1158/2159-8290.CD-21-0144

Article  CAS  PubMed  Google Scholar 

Amporndanai K, Meng X, Shang W et al (2021) Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives. Nat Commun 12:3061. https://doi.org/10.1038/s41467-021-23313-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

An L, Liu CT, Yu MJ et al (2012) Heme oxygenase-1 system, inflammation and ventilator-induced lung injury. Eur J Pharmacol 677:1–4. https://doi.org/10.1016/j.ejphar.2011.12.010

Article  CAS  PubMed  Google Scholar 

Anjum J, Mitra S, Das R et al (2022) A renewed concept on the MAPK signaling pathway in cancers: polyphenols as a choice of therapeutics. Pharmacol Res 184:106398. https://doi.org/10.1016/j.phrs.2022.106398

Article  CAS  PubMed  Google Scholar 

Anton DB, Pedreira JGB, Zvirtes ML et al (2023) Targeting SARS-CoV-2 main protease (MPro) with kinase inhibitors: a promising approach for discovering antiviral and anti-inflammatory molecules against SARS-CoV-2. J Chem Inf Model 63:4138–4146. https://doi.org/10.1021/acs.jcim.3c00324

Article  CAS  PubMed  Google Scholar 

Arthur JSC, Ley SC (2013) Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol 13:679–692. https://doi.org/10.1038/nri3495

Article  CAS  PubMed  Google Scholar 

Babaei F, Nassiri-Asl M, Hosseinzadeh H (2020) Curcumin (a constituent of turmeric): new treatment option against COVID-19. Food Sci Nutr 8:5215–5227. https://doi.org/10.1002/fsn3.1858

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bayati A, Kumar R, Francis V, McPherson PS (2021) SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis. J Biol Chem 296:100306. https://doi.org/10.1016/j.jbc.2021.100306

Article  CAS  PubMed  PubMed Central  Google Scholar 

Behl T, Rana T, Alotaibi GH et al (2022) Polyphenols inhibiting MAPK signalling pathway mediated oxidative stress and inflammation in depression. Biomed Pharmacother 146:112545. https://doi.org/10.1016/j.biopha.2021.112545

Article  CAS  PubMed  Google Scholar 

Beigel JH, Tomashek KM, Dodd LE et al (2020) Remdesivir for the treatment of covid-19—final report. N Engl J Med 383:1813–1826. https://doi.org/10.1056/NEJMoa2007764

Article  CAS  PubMed  Google Scholar 

Belvisi MG, Haddad EB, Battram C et al (2000) Anti-inflammatory properties of ebselen in a model of sephadex-induced lung inflammation. Eur Respir J 15:579–581. https://doi.org/10.1034/j.1399-3003.2000.15.25.x

Article  CAS  PubMed  Google Scholar 

Birra D, Benucci M, Landolfi L et al (2020) COVID 19: a clue from innate immunity. Immunol Res 68:161–168. https://doi.org/10.1007/s12026-020-09137-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bouhaddou M, Memon D, Meyer B et al (2020) The global phosphorylation landscape of SARS-CoV-2 infection. Cell 182:685-712.e19. https://doi.org/10.1016/j.cell.2020.06.034

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cáceres CJ, Cardenas-Garcia S, Carnaccini S et al (2021) Efficacy of GC-376 against SARS-CoV-2 virus infection in the K18 hACE2 transgenic mouse model. Sci Rep 11:1–13. https://doi.org/10.1038/s41598-021-89013-w

Article  CAS  Google Scholar 

Camprubí-Rimblas M, Guillamat-Prats R, Lebouvier T et al (2017) Role of heparin in pulmonary cell populations in an in-vitro model of acute lung injury. Respir Res 18:89. https://doi.org/10.1186/s12931-017-0572-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carabelli AM, Peacock TP, Thorne LG et al (2023) SARS-CoV-2 variant biology: immune escape, transmission and fitness. Nat Rev Microbiol 21:162–177. https://doi.org/10.1038/s41579-022-00841-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cargnello M, Roux PP (2011) Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev 75:50–83. https://doi.org/10.1128/mmbr.00031-10

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chakraborty C, Bhattacharya M, Dhama K (2023) SARS-CoV-2 vaccines, vaccine development technologies, and significant efforts in vaccine development during the pandemic: the lessons learned might help to fight against the next pandemic. Vaccines 11:682. https://doi.org/10.3390/vaccines11030682

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chaves OA, Sacramento CQ, Ferreira AC et al (2022) Atazanavir is a competitive inhibitor of SARS-CoV-2 Mpro, Impairing variants replication in vitro and in vivo. Pharmaceuticals 15:21. https://doi.org/10.3390/ph15010021

Article  CAS  Google Scholar 

Chen S, Ding Y, Tao W et al (2012) Naringenin inhibits TNF-α induced VSMC proliferation and migration via induction of HO-1. Food Chem Toxicol 50:3025–3031. https://doi.org/10.1016/j.fct.2012.06.006

Article  CAS  PubMed  Google Scholar 

Chen FT, Yang CM, Yang CH (2013) The protective effects of the proteasome inhibitor bortezomib (velcade) on ischemia-reperfusion injury in the rat retina. PLoS One 8:e64262. https://doi.org/10.1371/journal.pone.0064262

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen G, Wu D, Guo W et al (2020a) Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest 130:2620–2629. https://doi.org/10.1172/JCI137244

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen M, Chen Z, Huang D et al (2020b) Myricetin inhibits TNF-α-induced inflammation in A549 cells via the SIRT1/NF-κB pathway. Pulm Pharmacol Ther 65:102000. https://doi.org/10.1016/j.pupt.2021.102000

Article