Rosuvastatin repurposing for prophylaxis against ethanol-induced acute gastric ulceration in rats: a biochemical, histological, and ultrastructural perspective

Abdeen A, Aboubakr M, Elgazzar D, Abdo M, Abdelkader A, Ibrahim S, Elkomy A (2019) Rosuvastatin attenuates piroxicam-mediated gastric ulceration and hepato-renal toxicity in rats. Biomed Pharmacother 110:895–905. https://doi.org/10.1016/j.biopha.2018.11.004

Article  CAS  PubMed  Google Scholar 

Abdullah DA, Almukhtar H (2023) Statin gastroprotective mechanisms independent of gastric acid suppression. Iraqi J Pharm 20:89–194

Article  Google Scholar 

Açar Y, Ağagündüz D, De Cicco P, Capasso R (2023) Flavonoids: their putative neurologic roles, epigenetic changes, and gut microbiota alterations in Parkinson’s disease. Biomed Pharmacother 168:115788. https://doi.org/10.1016/j.biopha.2023.115788

Article  CAS  PubMed  Google Scholar 

Adinortey MB, Ansah C, Galyuon I, Nyarko A (2013) In vivo models used for evaluation of potential antigastroduodenal ulcer agents. Ulcers 2013:1–12. https://doi.org/10.1155/2013/796405

Article  CAS  Google Scholar 

Ağagündüz D, GençerBingöl F, Çelik E, Cemali Ö, Özenir Ç, Özoğul F, Capasso R (2022) Recent developments in the probiotics as live biotherapeutic products (LBPs) as modulators of gut brain axis related neurological conditions. J Transl Med 20:460. https://doi.org/10.1186/s12967-022-03609-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ağagündüz D, Kocaadam-Bozkurt B, Bozkurt O, Sharma H, Esposito R, Özoğul F, Capasso R (2022) Microbiota alteration and modulation in Alzheimer’s disease by gerobiotics: the gut-health axis for a good mind. Biomed Pharmacother 153:113430. https://doi.org/10.1016/j.biopha.2022.113430

Article  CAS  PubMed  Google Scholar 

Ağagündüz D, Cocozza E, Cemali Ö, Bayazıt AD, Nanì MF, Cerqua I, Morgillo F, Saygılı SK, BerniCanani R, Amero P, Capasso R (2023) Understanding the role of the gut microbiome in gastrointestinal cancer: a review. Front Pharmacol. https://doi.org/10.3389/fphar.2023.1130562

Article  PubMed  PubMed Central  Google Scholar 

Ağagündüz D, Icer MA, Yesildemir O, Koçak T, Kocyigit E, Capasso R (2023) The roles of dietary lipids and lipidomics in gut-brain axis in type 2 diabetes mellitus. J Transl Med 21:240. https://doi.org/10.1186/s12967-023-04088-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andreou I, Tousoulis D, Miliou A, Tentolouris C, Zisimos K, Gounari P, Siasos G, Papageorgiou N, Papadimitriou CA, Dimopoulos MA, Stefanadis C (2010) Effects of rosuvastatin on myeloperoxidase levels in patients with chronic heart failure: a randomized placebo-controlled study. Atherosclerosis 210:194–198. https://doi.org/10.1016/j.atherosclerosis.2009.10.046

Article  CAS  PubMed  Google Scholar 

Ansari JA, Bhandari U, Haque SE, Pillai KK (2012) Enhancement of antioxidant defense mechanism by pitavastatin and rosuvastatin on obesity-induced oxidative stress in Wistar rats. Toxicol Mech Methods 22:67–73. https://doi.org/10.3109/15376516.2011.603391

Article  CAS  PubMed  Google Scholar 

Bancroft JD, Layton C (2019) The hematoxylin and eosin. In: Suvarna SK, Layton C, Bancroft JD (eds) Bancroft’s theory and practice of histological techniques, 8th edn. Elsevier, Philadelphia, pp 126–138

Chapter  Google Scholar 

Begg M, Tarhuni M, Fotso NM, Gonzalez NA, Sanivarapu RR, Osman U, Latha Kumar A, Sadagopan A, Mahmoud A, Khan S (2023) Comparing the safety and efficacy of proton pump inhibitors and histamine-2 receptor antagonists in the management of patients with peptic ulcer disease: a systematic review. Cureus 15:e44341. https://doi.org/10.7759/cureus.44341

Article  PubMed  PubMed Central  Google Scholar 

Beiranvand M (2022) A review of the most common in vivo models of stomach ulcers and natural and synthetic anti-ulcer compounds: a comparative systematic study. Phytomedicine Plus 2:100264. https://doi.org/10.1016/j.phyplu.2022.100264

Article  Google Scholar 

Beutler E, Duron O, Kelly BM (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61:882–888

CAS  PubMed  Google Scholar 

Bhattacharyya A, Chattopadhyay R, Mitra S, Crowe SE (2014) Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev 94:329–354. https://doi.org/10.1152/physrev.00040.2012

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bode C, Christian Bode J (2003) Effect of alcohol consumption on the gut. Best Pract Res Clin Gastroenterol 17(4):575–592. https://doi.org/10.1016/S1521-6918(03)00034-9

Article  CAS  PubMed  Google Scholar 

Dash VB (2001) Herbal Treatment for Peptic Ulcer (Herbal Cure). B Jain Publishers Pvt Ltd 21 N New Delhi India

Dolkart O, Amar E, Shapira S, Marmor S, Steinberg EL, Weinbroum AA (2015) Protective effects of rosuvastatin in a rat model of lung contusion: stimulation of the cyclooxygenase 2–prostaglandin E-2 pathway. Surgery 157:944–953. https://doi.org/10.1016/j.surg.2014.12.017

Article  PubMed  Google Scholar 

Dykstra MJ, Reuss LE (2003) Biological electron microscopy. Theory techniques and troubleshooting, 2nd edn. Springer, Boston, MA US

Google Scholar 

Engen PA, Green SJ, Voigt RM, Forsyth CB, Keshavarzian A (2015) The gastrointestinal microbiome: alcohol effects on the composition of intestinal microbiota. Alcohol Res 37:223–236

PubMed  PubMed Central  Google Scholar 

Feng A, Chuang E, Wu SH, Wang JC, Chang SN, Lin CL, Kao CH (2015) The effect of statins on the occurrence of peptic ulcer. Eur J Intern Med 26:731–735. https://doi.org/10.1016/j.ejim.2015.07.015

Article  CAS  PubMed  Google Scholar 

Fujii T, Nakabayashi T, Hashimoto S, Kuwano H (2009) Statin use and risk of gastroduodenal ulcer and reflux esophagitis. Hepatogastroenterology 56:641–644

PubMed  Google Scholar 

Gebrayel P, Nicco C, Al Khodor S, Bilinski J, Caselli E, Comelli EM, Egert M, Giaroni C, Karpinski TM, Loniewski I, Mulak A, Reygner J, Samczuk P, Serino M, Sikora M, Terranegra A, Ufnal M, Villeger R, Pichon C, Konturek P, Edeas M (2022) Microbiota medicine: towards clinical revolution. J Transl Med 20:111. https://doi.org/10.1186/s12967-022-03296-9

Article  PubMed  PubMed Central  Google Scholar 

Ghaisas MM, Dandawate PR, Zawar SA, Ahire YS, Gandhi SP (2010) Antioxidant, antinociceptive and anti-inflammatory activities of atorvastatin and rosuvastatin in various experimental models. Inflammopharmacology 18:169–177. https://doi.org/10.1007/s10787-010-0044-6

Article  CAS  PubMed  Google Scholar 

Günbatan T, Gürbüz İ, Bedir E, GençlerÖzkan AM, Özçınar Ö (2020) Investigations on the antiulcerogenic activity of Sideritis caesarea H Duman Aytaç & Başer. J Ethnopharmacol. https://doi.org/10.1016/j.jep.2020.112920

Article  PubMed  Google Scholar 

Haber PS, Kortt NC (2021) Alcohol use disorder and the gut. Addiction 116:658–667. https://doi.org/10.1111/add.15147

Article  PubMed  Google Scholar 

Holdgate GA, Ward WHJ, McTaggart F (2003) Molecular mechanism for inhibition of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase by rosuvastatin. Biochem Soc Trans 31:528–531. https://doi.org/10.1042/bst0310528

Article  CAS  PubMed  Google Scholar 

Hsia J, MacFadyen JG, Monyak J, Ridker PM (2011) Cardiovascular event reduction and adverse events among subjects attaining low-density lipoprotein cholesterol <50 mg/dl with rosuvastatin. J Am Coll Cardiol 57:1666–1675. https://doi.org/10.1016/j.jacc.2010.09.082

Article  CAS  PubMed  Google Scholar 

Hu Y, Wang X, Ye L, Li C, Chen W, Cheng H (2020) Rosuvastatin Alleviates intestinal injury by down-regulating the CD40 pathway in the intestines of rats following traumatic brain injury. Front Neurol 11:816. https://doi.org/10.3389/fneur.2020.00816

Article  PubMed  PubMed Central  Google Scholar 

Ismail IF, Golbabapour S, Hassandarvish P, Hajrezaie M, Abdul Majid N, Kadir FA, Al-Bayaty F, Awang K, Hazni H, Abdulla MA (2012) Gastroprotective activity of polygonum chinense aqueous leaf extract on ethanol-induced hemorrhagic mucosal lesions in rats. Evidence-Based Complement Altern Med 2012:1–9. https://doi.org/10.1155/2012/404012

Article  Google Scholar 

Jowkar F, Namazi MR (2010) Statins in dermatology. Int J Dermatol 49:1235–1243. https://doi.org/10.1111/j.1365-4632.2010.04579.x

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