Agrawal M, Allin KH, Petralia F, Colombel JF, Jess T (2022) Multiomics to elucidate inflammatory bowel disease risk factors and pathways. Nat Rev Gastroenterol Hepatol 19:399–409

Article  PubMed  PubMed Central  Google Scholar 

Ananthakrishnan AN (2015) Epidemiology and risk factors for IBD. Nat Rev Gastroenterol Hepatol 12:205–217

Article  PubMed  Google Scholar 

Asadzadeh Aghdaei H, Nazemalhosseini-Mojarad E, Nadalian B, Nadalian B, Houri H (2022) Overrepresentation of Enterobacteriaceae and Escherichia coli is the major gut microbiome signature in Crohn’s disease and ulcerative colitis; a comprehensive metagenomic analysis of IBDMDB datasets. Front Cell Infect Microbiol 12:1015890

Article  PubMed  PubMed Central  Google Scholar 

Bajic D, Niemann A, Hillmer AK, Mejias-Luque R, Bluemel S, Docampo M, Funk MC, Tonin E, Boutros M, Schnabl B, Busch DH, Miki T, Schmid RM, van den Brink MRM, Gerhard M, Stein-Thoeringer CK (2020) Gut Microbiota-Derived Propionate Regulates the Expression of Reg3 Mucosal Lectins and Ameliorates Experimental Colitis in Mice. J Crohns Colitis 14:1462–1472

Article  PubMed  PubMed Central  Google Scholar 

Bhattacharya A, Osterman MT (2020) Biologic Therapy for Ulcerative Colitis. Gastroenterol Clin North Am 49:717–729

Article  PubMed  Google Scholar 

Bian X, Wu W, Yang L, Lv L, Wang Q, Li Y, Ye J, Fang D, Wu J, Jiang X, Shi D, Li L (2019) Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice. Front Microbiol 10:2259

Article  PubMed  PubMed Central  Google Scholar 

Chambers ES, Byrne CS, Morrison DJ, Murphy KG, Preston T, Tedford C, Garcia-Perez I, Fountana S, Serrano-Contreras JI, Holmes E, Reynolds CJ, Roberts JF, Boyton RJ, Altmann DM, McDonald JAK, Marchesi JR, Akbar AN, Riddell NE, Wallis GA, Frost GS (2019) Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial. Gut 68:1430–1438

Article  CAS  PubMed  Google Scholar 

Chelakkot C, Ghim J, Ryu SH (2018) Mechanisms regulating intestinal barrier integrity and its pathological implications. Exp Mol Med 50:1–9

Article  CAS  PubMed  Google Scholar 

Di Tommaso N, Gasbarrini A, Ponziani FR (2021) Intestinal Barrier in Human Health and Disease. Int J Environ Res Public Health 18:12836

Article  PubMed  PubMed Central  Google Scholar 

Dinallo V, Marafini I, Di Fusco D, Laudisi F, Franzè E, Di Grazia A, Figliuzzi MM, Caprioli F, Stolfi C, Monteleone I, Monteleone G (2019) Neutrophil Extracellular Traps Sustain Inflammatory Signals in Ulcerative Colitis. J Crohns Colitis 13:772–784

Article  PubMed  Google Scholar 

Flynn S, Eisenstein S (2019) Inflammatory Bowel Disease Presentation and Diagnosis. Surg Clin North Am 99:1051–1062

Article  PubMed  Google Scholar 

Ganesh BP, Klopfleisch R, Loh G, Blaut M (2013) Commensal Akkermansia muciniphila exacerbates gut inflammation in Salmonella Typhimurium-infected gnotobiotic mice. PLoS ONE 8:e74963

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gearry RB (2016) IBD and Environment: Are There Differences between East and West. Dig Dis 34:84–89

Article  PubMed  Google Scholar 

Guo XY, Liu XJ, Hao JY (2020) Gut microbiota in ulcerative colitis: insights on pathogenesis and treatment. J Dig Dis 21:147–159

Article  PubMed  Google Scholar 

Jin J, Gao L, Zou X, Zhang Y, Zheng Z, Zhang X, Li J, Tian Z, Wang X, Gu J, Zhang C, Wu T, Wang Z, Zhang Q (2022) Gut Dysbiosis Promotes Preeclampsia by Regulating Macrophages and Trophoblasts. Circ Res 131:492–506

Article  CAS  PubMed  Google Scholar 

Kaplan GG (2015) The global burden of IBD: from 2015 to 2025. Nat Rev Gastroenterol Hepatol 12:720–727

Article  PubMed  Google Scholar 

Ko HM, Jee W, Lee D, Jang HJ, Jung JH (2022) Ophiopogonin D increase apoptosis by activating p53 via ribosomal protein L5 and L11 and inhibiting the expression of c-Myc via CNOT2. Front Pharmacol 13:974468

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lam P, Cheung F, Tan HY, Wang N, Yuen MF, Feng Y (2016) Hepatoprotective Effects of Chinese Medicinal Herbs: A Focus on Anti-Inflammatory and Anti-Oxidative Activities. Int J Mol Sci 17:465

Article  PubMed  PubMed Central  Google Scholar 

Lasa JS, Olivera PA, Danese S, Peyrin-Biroulet L (2022) Efficacy and safety of biologics and small molecule drugs for patients with moderate-to-severe ulcerative colitis: a systematic review and network meta-analysis. Lancet Gastroenterol Hepatol 7:161–170

Article  PubMed  Google Scholar 

Li W, Ji L, Tian J, Tang W, Shan X, Zhao P, Chen H, Zhang C, Xu M, Lu R, Guo W (2021) Ophiopogonin D alleviates diabetic myocardial injuries by regulating mitochondrial dynamics. J Ethnopharmacol 271:113853

Article  CAS  PubMed  Google Scholar 

Li MX, Li MY, Lei JX, Wu YZ, Li ZH, Chen LM, Zhou CL, Su JY, Huang GX, Huang XQ, Zheng XB (2022) Huangqin decoction ameliorates DSS-induced ulcerative colitis: Role of gut microbiota and amino acid metabolism, mTOR pathway and intestinal epithelial barrier. Phytomedicine 100:154052

Article  PubMed  Google Scholar 

Lu Z, Wu C, Zhu M, Song W, Wang H, Wang J, Guo J, Li N, Liu J, Li Y, Xu H (2020) Ophiopogonin D’ induces RIPK1-dependent necroptosis in androgen-dependent LNCaP prostate cancer cells. Int J Oncol 56:439–447

CAS  PubMed  Google Scholar 

Maaser C, Sturm A, Vavricka SR, Kucharzik T, Fiorino G, Annese V, Calabrese E, Baumgart DC, Bettenworth D, Borralho Nunes P, Burisch J (2019) ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications. J Crohns Colitis 13:144–164

Article  PubMed  Google Scholar 

Mentella MC, Scaldaferri F, Pizzoferrato M, Gasbarrini A, Miggiano GAD (2020) Nutrition, IBD and Gut Microbiota: A Review. Nutrients 12:944

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nagpal R, Neth BJ, Wang S, Craft S, Yadav H (2019) Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer’s disease markers in subjects with mild cognitive impairment. EBioMedicine 47:529–542

Article  PubMed  PubMed Central  Google Scholar 

Ni J, Wu GD, Albenberg L, Tomov VT (2017) Gut microbiota and IBD: causation or correlation? Nat Rev Gastroenterol Hepatol 14:573–584

Article  PubMed  PubMed Central  Google Scholar 

Papamichael K, Lin S, Moore M, Papaioannou G, Sattler L, Cheifetz AS (2019) Infliximab in inflammatory bowel disease. Ther Adv Chronic Dis 10:2040622319838443

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roda G, Jharap B, Neeraj N, Colombel JF (2016) Loss of Response to Anti-TNFs: Definition, Epidemiology, and Management. Clin Transl Gastroenterol 7:e135

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rokkas T, Portincasa P, Koutroubakis IE (2018) Fecal calprotectin in assessing inflammatory bowel disease endoscopic activity: a diagnostic accuracy meta-analysis. J Gastrointestin Liver Dis 27:299–306

Article  PubMed  Google Scholar 

Segal JP, Leblanc JF, Hart AL (2021) Ulcerative Colitis: an Update Clin Med (lond) 21:135–139

PubMed  Google Scholar 

Seyedian SS, Nokhostin F, Malamir MD (2019) A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease. J Med Life 12:113–122

Article  PubMed  PubMed Central