Aleman RS, Moncada M, Aryana KJ (2023) Leaky gut and the ingredients that help treat it: a review. Molecules 28(2):619

Article  CAS  PubMed  PubMed Central  Google Scholar 

Amic F, Drmic D, Bilic Z et al (2018) Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157 L-NAME and L-Arginine. World J Gastroenterol 24(47):5366–5378

Article  PubMed  PubMed Central  Google Scholar 

Anderson G, Seo M, Berk M et al (2016) Gut permeability and microbiota in Parkinson’s disease: role of depression, tryptophan catabolites, oxidative and nitrosative stress and melatonergic pathways. Curr Pharm Des 22(40):6142–6151

Article  CAS  PubMed  Google Scholar 

Balenovic D, Bencic ML, Udovicic M et al (2009) Inhibition of methyldigoxin-induced arrhythmias by pentadecapeptide BPC 157: a relation with NO-system. Regul Pept 156(1–3):83–89

Article  CAS  PubMed  Google Scholar 

Baric M, Sever AZ, Vuletic LB et al (2016) Stable gastric pentadecapeptide BPC 157 heals rectovaginal fistula in rats. Life Sci 148:63–70

Article  CAS  PubMed  Google Scholar 

Barisic I, Balenovic D, Klicek R et al (2013) Mortal hyperkalemia disturbances in rats are NO-system related. The life saving effect of pentadecapeptide BPC 157. Regul Pept 181:50–66

Article  CAS  PubMed  Google Scholar 

Barisic I, Balenovic D, Udovicic M et al (2022) Stable gastric pentadecapeptide BPC 157 may counteract myocardial infarction induced by isoprenaline in rats. Biomedicines 10(2):265

Article  CAS  PubMed  PubMed Central  Google Scholar 

Becejac T, Cesarec V, Drmic D et al (2018) An endogenous defensive concept, renewed cytoprotection/adaptive cytoprotection: intra(per)-oral/intragastric strong alcohol in rat. Involvement of pentadecapeptide BPC 157 and nitric oxide system. J Physiol Pharmacol 69(3):429–440

CAS  Google Scholar 

Bedekovic V, Mise S, Anic T et al (2003) Different effect of antiulcer agents on rat cysteamine-induced duodenal ulcer after sialoadenectomy, but not gastrectomy. Eur J Pharmacol 477(1):73–80

Article  CAS  PubMed  Google Scholar 

Belosic Halle Z, Vlainic J, Drmic D et al (2017) Class side effects: decreased pressure in the lower oesophageal and the pyloric sphincters after the administration of dopamine antagonists, neuroleptics, anti-emetics, L-NAME, pentadecapeptide BPC 157 and L-arginine. Inflammopharmacology 25:511–522

Article  CAS  Google Scholar 

Bilic I, Zoricic I, Anic T et al (2001) Haloperidol-stomach lesions attenuation by pentadecapeptide BPC 157, omeprazole, bromocriptine, but not atropine, lansoprazole, pantoprazole, ranitidine, cimetidine and misoprostol in mice. Life Sci 68(16):1905–1912

Article  CAS  PubMed  Google Scholar 

Bilic M, Bumber Z, Blagaic AB et al (2005) The stable gastric pentadecapeptide BPC 157, given locally, improves CO2 laser healing in mice. Burns 31(3):310–315

Article  CAS  PubMed  Google Scholar 

Bilic Z, Gojkovic S, Kalogjera L et al (2021) Novel insight into Robert’s cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-NG-nitro-L-arginine methyl ester worsening. J Physiol Pharmacol 72(6):939–955

CAS  Google Scholar 

Bódis B, Karádi O, Nagy L et al (1997a) Direct cellular effects of some mediators, hormones and growth factor-like agents on denervated (isolated) rat gastric mucosal cells. J Physiol Paris 91(3–5):183–187

Article  PubMed  Google Scholar 

Bódis B, Karádi O, Németh P et al (1997b) Evidence for direct cellular protective effect of PL-10 substances (synthesized parts of body protection compound, BPC) and their specificity to gastric mucosal cells. Life Sci 61(16):PL243-248

Article  Google Scholar 

Brcic L, Brcic I, Staresinic M et al (2009) Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing. J Physiol Pharmacol 60(Suppl 7):191–196

PubMed  Google Scholar 

Camillleri M (2019) Leaky gut: mechanisms, measurement and clinical implications in humans. Gut 68(8):1516–1526

Article  Google Scholar 

Cerovecki T, Bojanic I, Brcic L et al (2010) Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat. J Orthop Res 28(9):1155–1161

Cesarec V, Becejac T, Misic M et al (2013) Pentadecapeptide BPC 157 and the esophagocutaneous fistula healing therapy. Eur J Pharmacol 701(1–3):203–212

Article  CAS  PubMed  Google Scholar 

Chang CH, Tsai WC, Lin MS et al  (2011) The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol 110(3):774–780

Article  CAS  PubMed  Google Scholar 

Chang CH, Tsai WC, Hsu YH et al (2014) Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules 19:19066–19077

Article  PubMed  PubMed Central  Google Scholar 

Cheer SM, Wagstaff AJ (2004) Quetiapine. A review of its use in the management of schizophrenia. CNS Drugs 18:173–199

Article  CAS  PubMed  Google Scholar 

Deng X, Szabo S, Chen L et al (2011) New cell therapy using bone marrow-derived stem cells/endothelial progenitor cells to accelerate neovascularization in healing of experimental ulcerative colitis. Curr Pharm Des 17(16):1643–1651

Article  CAS  PubMed  Google Scholar 

Djakovic Z, Djakovic I, Cesarec V et al (2016) Esophagogastric anastomosis in rats: improved healing by BPC 157 and L-arginine, aggravated by L-NAME. World J Gastroenterol 22(41):9127–9140

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dobric I, Drvis P, Petrovic I et al (2007) Prolonged esophagitis after primary dysfunction of the pyloric sphincter in the rat and therapeutic potential of the gastric pentadecapeptide BPC 157. J Pharmacol Sci 104(1):7–18

Article  CAS  PubMed  Google Scholar 

Docherty JR, Alsufyani HA (2021) Pharmacology of drugs used as stimulants. J Clin Pharmacol 61(Suppl 2):S53–S69

CAS  PubMed  Google Scholar 

Drmic D, Samara M, Vidovic T et al (2018) Counteraction of perforated cecum lesions in rats: effects of pentadecapeptide BPC 157 L-NAME and L-Arginine. World J Gastroenterol 24(48):5462–5476

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duplancic B, Stambolija V, Holjevac J et al (2014) Pentadecapeptide BPC 157 and anaphylactoid reaction in rats and mice after intravenous dextran and white egg administration. Eur J Pharmacol 727:75–79

Article  CAS  PubMed  Google Scholar 

Duzel A, Vlainic J, Antunovic M et al (2017) Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights. World J Gastroenterol 23(48):8465–8488

Article  PubMed  PubMed Central  Google Scholar 

Erceg D, Simicevic VN, Kolega M et al (1997) Some aspects of the effects of PL-10.1.AK-15 on the gastrointestinal tract. J Physiol Paris 91(3–5):179–181

Article  CAS  PubMed  Google Scholar 

Fändriks L (2017) Roles of the gut in the metabolic syndrome: an overview. J Intern Med 281(4):319–336

Article  PubMed  Google Scholar 

Ferrucci M, Limanaqi F, Ryskalin L, Biagioni F, Busceti CL, Fornai F (2019) The effects of amphetamine and methamphetamine on the release of norepinephrine, dopamine and acetylcholine from the brainstem reticular formation. Front Neuroanat 13:48

Article  CAS  PubMed  PubMed Central  Google Scholar 

Filosevic A, Andretic Waldowski R, Sikiric P et al (2018) Stable gastric pentadecapeptide BPC 157 antagonizes hydrogen peroxide induced oxidative stress in Drosophila melanogaster. FASEB J 31(S1):667