Abid F, Saleem M, Maqbool T, Shakoori TA, Hadi F, Muhammad T et al (2022) In vivo anti-inflammatory and anti-arthritic potential of ethanolic acacia modesta extract on CFA-induced adjuvant arthritic rats. Pak J Zool. https://doi.org/10.17582/journal.pjz/20210805070809

Article  Google Scholar 

Akhter S, Irfan HM, Alamgeer J, S., Shahzad, M., & Latif, M. B. (2022a) Nerolidol: a potential approach in rheumatoid arthritis through reduction of TNF-α, IL-1β, IL-6, NF-kB, COX-2 and antioxidant effect in CFA-induced arthritic model. Inflammopharmacology 30(2):537–548

Article  CAS  PubMed  Google Scholar 

Akhter S, Rehman A, Abidi S, Arjmand F, Tabassum S (2022b) Synthesis, structural insights, and biological screening of DNA targeted Ru (ii)(η 6-p-cymene) complexes containing bioactive amino-benzothiazole ligand scaffolds. New J Chem 46(23):11462–11473

Article  CAS  Google Scholar 

Alamgeer U, A. M., & Hasan, U. H. (2017) Anti-arthritic activity of aqueous-methanolic extract and various fractions of Berberis orthobotrys Bien ex Aitch. BMC Complement Altern Med 17:1–16

Article  Google Scholar 

Al-Joufi FA, Uttra AM, Qasim S, Iqbal U, Sial NT, Alhumaid NM (2024) Anti-arthritic and immunomodulatory efficacy of Micromeria biflora Benth extract and its fractions in rats by restoring oxidative stress, metalloproteinases, pro-inflammatory and anti-inflammatory cytokines network. Inflammopharmacology. https://doi.org/10.1007/s10787-024-01479-y

Article  PubMed  Google Scholar 

Aslam S, Younis W, Malik MNH, Jahan S, Alamgeer U, A. M., et al (2022) Pharmacological evaluation of anti-arthritic potential of terpinen-4-ol using in vitro and in vivo assays. Inflammopharmacology 30(3):945–959

Article  CAS  PubMed  Google Scholar 

Bai J, Farias-Pereira R, Jang M, Zhang Y, Lee SM, Kim Y-S et al (2021) Azelaic acid promotes caenorhabditis elegans longevity at low temperature via an increase in fatty acid desaturation. Pharm Res 38:15–26

Article  CAS  PubMed  Google Scholar 

Biswas D, Somkuwar BG, Borah JC, Varadwaj PK, Gupta S, Khan ZA et al (2023) Phytochemical mediated modulation of COX-3 and NFκB for the management and treatment of arthritis. Sci Rep 13(1):13612

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai X, Wong Y, Zhou H, Xie Y, Liu Z, Jiang Z et al (2006) The comparative study of Sprague-Dawley and Lewis rats in adjuvant-induced arthritis. Naunyn Schmiedebergs Arch Pharmacol 373:140–147

Article  CAS  PubMed  Google Scholar 

Dar E, Mobashar A, Shabbir A, Mushtaq MN, Anjum I, Gaafar Z, A.-R., et al (2023) Mechanistic evaluation of antiarthritic effects of citronellol in CFA-induced arthritic rats. ACS Omega 8(47):44955–44963

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fitton A, Goa KL (1991) Azelaic acid: a review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders. Drugs 41:780–798

Article  CAS  PubMed  Google Scholar 

Gao Q, Qin H, Zhu L, Li D, Hao X (2020) Celastrol attenuates collagen-induced arthritis via inhibiting oxidative stress in rats. Int Immunopharmacol 84:106527

Article  CAS  PubMed  Google Scholar 

Garcia-Alonso V, Titos E, Alcaraz-Quiles J, Rius B, Lopategi A, Lopez-Vicario C et al (2016) Prostaglandin E2 exerts multiple regulatory actions on human obese adipose tissue remodeling, inflammation, adaptive thermogenesis and lipolysis. PLoS ONE 11(4):e0153751

Article  PubMed  PubMed Central  Google Scholar 

Gohil P, Patel V, Deshpande S, Chorawala M, Shah G (2018) Anti-arthritic activity of cell wall content of Lactobacillus plantarum in freund’s adjuvant-induced arthritic rats: involvement of cellular inflammatory mediators and other biomarkers. Inflammopharmacology 26:171–181

Article  CAS  PubMed  Google Scholar 

Gowayed MA, Refaat R, Ahmed WM, El-Abhar HS (2015) Effect of galantamine on adjuvant-induced arthritis in rats. Eur J Pharmacol 764:547–553

Article  CAS  PubMed  Google Scholar 

Gul B, Anwar R, Saleem M, Noor A, Ullah MI (2023) C assia absus-mediated upregulation of IL-4, IL-10 and downregulation of IL-1β, IL-6, TNF-α, NF-κB IFN-γ in CFA-induced arthritis model. Inflammopharmacology 31(3):1241–1256

Article  CAS  PubMed  Google Scholar 

Hassan UH, Shahzad M, Shabbir A, Jahan S, Saleem M, Bukhari IA et al (2019) Amelioration of adjuvant induced arthritis in Sprague Dawley rats through modulation of inflammatory mediators by Ribes alpestre Decne. J Ethnopharmacol 235:460–471

Article  CAS  PubMed  Google Scholar 

Iqbal U, Malik A, Sial NT, Uttra AM, Rehman MFU, Mehmood MH (2024) Molecular insights of Eucalyptol (1, 8-Cineole) as an anti-arthritic agent: in vivo and in silico analysis of IL-17, IL-10, NF-κB, 5-LOX and COX-2. Inflammopharmacology. https://doi.org/10.1007/s10787-024-01465-4

Article  PubMed  Google Scholar 

Izbicka E, Streeper RT (2021) Azelaic acid esters as pluripotent immunomodulatory molecules: nutritional supplements or drugs. Nutraceuticals 1(1):42–53

Article  Google Scholar 

Jakhar R, Dangi M, Khichi A, Chhillar AK (2020) Relevance of molecular docking studies in drug designing. Curr Bioinform 15(4):270–278

Article  CAS  Google Scholar 

Kany S, Vollrath JT, Relja B (2019) Cytokines in inflammatory disease. Int J Mol Sci 20(23):6008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khan YH, Qasim S, Uttra AM, Alotaibi NH, Alanazi AS, Alzarea AI et al (2023) Enalapril attenuated CFA provoked arthritic manifestation by modulating proinflammatory and anti-inflammatory cytokine network. Life Sci 324:121742

Article  CAS  PubMed  Google Scholar 

Kugyelka R, Kohl Z, Olasz K, Mikecz K, Rauch TA, Glant TT et al (2016) Enigma of IL-17 and Th17 cells in rheumatoid arthritis and in autoimmune animal models of arthritis. Mediat Inflamm. https://doi.org/10.1155/2016/6145810

Article  Google Scholar 

Liao Y, Wu X, Luo W, Chen J, Huang Y, Ma K et al (2023) Azelaic acid regulates the renin-angiotensin system and improves colitis based on network pharmacology and experimentation. ACS Omega 8(17):15217–15228

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin B, Zhao Y, Han P, Yue W, Ma X-Q, Rahman K et al (2014) Anti-arthritic activity of Xanthium strumarium L. extract on complete Freund׳ s adjuvant induced arthritis in rats. J Ethnopharmacol 155(1):248–255

Article  PubMed  Google Scholar 

Mahnashi MH, Jabbar Z, Alamgeer I, H. M., Asim, M. H., Akram, M., et al (2021) Venlafaxine demonstrated anti-arthritic activity possibly through down regulation of TNF-α, IL-6, IL-1β, and COX-2. Inflammopharmacology 29:1413–1425

Article  CAS  PubMed  Google Scholar 

Mbiantcha M, Almas J, Shabana SU, Nida D, Aisha F (2017) Anti-arthritic property of crude extracts of Piptadeniastrum africanum (Mimosaceae) in complete Freund’s adjuvant-induced arthritis in rats. BMC Complement Altern Med 17(1):1–16

Article  Google Scholar 

Nawaz S, Irfan HM, Akram M, Jahan S (2023a) Linalool: monoterpene alcohol effectiveness in chronic synovitis through lowering interleukin-17, spleen and thymus indices. Int Immunopharmacol 121:110517

Article  CAS  PubMed  Google Scholar 

Nawaz S, Irfan HM, Alamgeer A, L., & Jahan, S. (2023b) Attenuation of CFA-induced chronic inflammation by a bicyclic monoterpene fenchone targeting inducible nitric oxide, prostaglandins C-reactive protein and urea. Inflammopharmacology 31(5):2479–2491

Article  CAS  PubMed  Google Scholar 

Parveen N, Sheikh A, Molugulu N, Annadurai S, Wahab S, Kesharwani P (2023) Drug permeation enhancement, efficacy, and safety assessment of azelaic acid loaded SNEDDS hydrogel to overcome the treatment barriers of atopic dermatitis. Environ Res 236:116850

Article  CAS  PubMed  Google Scholar 

Pujadas G, Vaque M, Ardevol A, Blade C, Salvado M, Blay M et al (2008) Protein-ligand docking: a review of recent advances and future perspectives. Curr Pharm Anal 4(1):1–19

Article