Advances in Pharmacology and Pharmacy Vol. 12(4), pp. 313 - 325
DOI: 10.13189/app.2024.120404
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Sopan N. Nangare 1, Tejas Dhamane 1, Divya Patil 1, Pravin O. Patil 1, Ketan B. Patil 2, Mahendra R. Mahajan 1,*
1 Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, India
2 Department of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, India

ABSTRACT

Diabetes mellitus (DM) remains a persistent and significant global health challenge, profoundly affecting the well-being of individuals. In response to this escalating health concern, the emergence of teneligliptin, an innovative dipeptidyl peptidase-4 (DPP-4) inhibitor medication, presents a promising avenue for managing type 2 DM (T2DM). This comprehensive review aims to provide a thorough examination of the various analytical strategies utilized for the quantification of teneligliptin. It encompasses a range of analytical techniques, including spectroscopic UV analysis, chromatographic approaches such as reversed-phase high-performance liquid chromatography (RP-HPLC), high-performance thin-layer chromatography (HPTLC), liquid chromatography-mass spectrometry (LC-MS), and ultra-performance liquid chromatography (UPLC). Additionally, the focus extends to the detection and quantification of teneligliptin within pharmaceutical formulations. Throughout this comprehensive review, it is noteworthy that the reported lower limit of detection impressively stands at 0.3 μg/mL, underscoring the remarkable sensitivity of the employed analytical methods. These findings underscore the potential of the developed and validated techniques for accurate quantitative assessment of teneligliptin, both in its pure form and pharmaceutical formulations. In summary, this review represents a significant advancement in the field, shedding light on the available avenues for estimating teneligliptin within pharmaceutical formulations. The analytical approaches discussed herein contribute to the existing body of scientific knowledge and provide invaluable tools for researchers and healthcare professionals dedicated to improving the management of T2DM.

KEYWORDS
Teneligliptin, Metformin, Diabetes Mellitus, UV, RP-HPLC, HPTLC, LC-MS

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Sopan N. Nangare , Tejas Dhamane , Divya Patil , Pravin O. Patil , Ketan B. Patil , Mahendra R. Mahajan , "An Insightful Overview on Teneligliptin Hydrobromide Hydrate: Analytical Strategies," Advances in Pharmacology and Pharmacy, Vol. 12, No. 4, pp. 313 - 325, 2024. DOI: 10.13189/app.2024.120404.

(b). APA Format:
Sopan N. Nangare , Tejas Dhamane , Divya Patil , Pravin O. Patil , Ketan B. Patil , Mahendra R. Mahajan (2024). An Insightful Overview on Teneligliptin Hydrobromide Hydrate: Analytical Strategies. Advances in Pharmacology and Pharmacy, 12(4), 313 - 325. DOI: 10.13189/app.2024.120404.