Sakamoto KM, Kim KB, Kumagai A, Mercurio F, Crews CM, Deshaies RJ. Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation. Proc Natl Acad Sci USA. 2001;98:8554–9. https://doi.org/10.1073/pnas.141230798
Article CAS PubMed PubMed Central Google Scholar
Li K, Crews CM. PROTACs: past, present and future. Chem Soc Rev. 2022;51:5214–36. https://doi.org/10.1039/d2cs00193d
Article CAS PubMed PubMed Central Google Scholar
Lebraud H, Wright DJ, Johnson CN, Heightman TD. Protein degradation by in-cell self-assembly of proteolysis targeting chimeras. ACS Cent Sci. 2016;2:927–34. https://doi.org/10.1021/acscentsci.6b00280
Article CAS PubMed PubMed Central Google Scholar
Gui W, Giardina SF, Balzarini M, Barany F, Kodadek T. Reversible assembly of proteolysis targeting chimeras. ACS Chem Biol. 2023;18:1582–93. https://doi.org/10.1021/acschembio.3c00199
Article CAS PubMed Google Scholar
Pasieka A, Diamanti E, Uliassi E, Laura Bolognesi M. Click chemistry and targeted degradation: a winning combination for medicinal chemists? ChemMedChem. 2023;18:e202300422. https://doi.org/10.1002/cmdc.202300422
Article CAS PubMed Google Scholar
Tomoshige S, Ishikawa M. In vivo synthetic chemistry of proteolysis targeting chimeras (PROTACs). Bioorg Med Chem. 2021;41:116221. https://doi.org/10.1016/j.bmc.2021.116221
Article CAS PubMed Google Scholar
Yang C, Tripathi R, Wang BH. Click chemistry in the development of PROTACs. RSC Chem Biol. 2023;5:189–97. https://doi.org/10.1039/d3cb00199g
Article CAS PubMed PubMed Central Google Scholar
Kondengadan SM, Bansal S, Yang C, Liu D, Fultz Z, Wang B. Click chemistry and drug delivery: a bird’s-eye view. Acta Pharm Sin B. 2023;13:1990–2016. https://doi.org/10.1016/j.apsb.2022.10.015
Article CAS PubMed Google Scholar
Cal PM, Frade RF, Chudasama V, Cordeiro C, Caddick S, Gois PM. Targeting cancer cells with folic acid-iminoboronate fluorescent conjugates. Chem Commun. 2014;50:5261–3. https://doi.org/10.1039/c3cc47534d
Draganov AB, Wang K, Holmes J, Damera K, Wang D, Dai C, et al. Click with a boronic acid handle: a neighboring group-assisted click reaction that allows ready secondary functionalization. Chem Commun. 2015;51:15180–3. https://doi.org/10.1039/c5cc05890b
Bandyopadhyay A, Gao J. Iminoboronate formation leads to fast and reversible conjugation chemistry of α-nucleophiles at neutral pH. Chemistry. 2015;21:14748–52. https://doi.org/10.1002/chem.201502077
Article CAS PubMed PubMed Central Google Scholar
Cambray S, Gao J. Versatile bioconjugation chemistries of ortho-boronyl aryl ketones and aldehydes. Acc Chem Res. 2018;51:2198–206. https://doi.org/10.1021/acs.accounts.8b00154
Article CAS PubMed PubMed Central Google Scholar
Chio TI, Gu H, Mukherjee K, Tumey LN, Bane SL. Site-specific bioconjugation and multi-bioorthogonal labeling via rapid formation of a boron-nitrogen heterocycle. Bioconjugate Chem. 2019;30:1554–64. https://doi.org/10.1021/acs.bioconjchem.9b00246
Pang Y, Huang M, Fan Y, Yeh HW, Xiong Y, Ng HL, et al. Development, characterization, and structural analysis of a genetically encoded red fluorescent peroxynitrite biosensor. ACS Chem Biol. 2023;18:1388–97. https://doi.org/10.1021/acschembio.3c00139
Article CAS PubMed Google Scholar
Buckley DL, Raina K, Darricarrere N, Hines J, Gustafson JL, Smith IE, et al. HaloPROTACS: use of small molecule PROTACs to induce degradation of HaloTag fusion proteins. ACS Chem Biol. 2015;10:1831–7. https://doi.org/10.1021/acschembio.5b00442
Article CAS PubMed PubMed Central Google Scholar
Ody BK, Zhang J, Nelson SE, Xie Y, Liu R, Dodd CJ, et al. Synthesis and evaluation of cereblon-recruiting HaloPROTACs. Chembiochem. 2023;24:e202300498. https://doi.org/10.1002/cbic.202300498
Article CAS PubMed Google Scholar
Tovell H, Testa A, Maniaci C, Zhou H, Prescott AR, Macartney T, et al. Rapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader. ACS Chem Biol. 2019;14:882–92. https://doi.org/10.1021/acschembio.8b01016
Article CAS PubMed PubMed Central Google Scholar
Sarott RC, You I, Li YD, Toenjes ST, Donovan KA, Seo P, et al. Chemical specification of E3 ubiquitin ligase engagement by cysteine-reactive chemistry. J Am Chem Soc. 2023;145:21937–44. https://doi.org/10.1021/jacs.3c06622
Article CAS PubMed Google Scholar
Li K, Weidman C, Gao J. Dynamic formation of imidazolidino boronate enables design of cysteine-responsive peptides. Org Lett. 2018;20:20–23. https://doi.org/10.1021/acs.orglett.7b03116
Article CAS PubMed Google Scholar
Li KC, Wang WJ, Gao JM. Fast and stable N-terminal cysteine modification through thiazolidino boronate mediated acyl transfer. Angew Chem Int Ed. 2020;59:14246–50. https://doi.org/10.1002/anie.202000837
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