SIRT1 downregulation in pneumonia is associated with an immature neutrophil response and increased disease severity

From the Division of Trauma, Critical Care, and Burn at The Ohio State University Wexner Medical Center (H.E.L., K.M.S., J.H., N.W., E.C.P., C.A.S.), Department of Neurology at The Ohio State University Wexner Medical Center (J.A.S., A.R.S.), The Ohio State University, and The Ohio State University (N.W., E.C.P.), Columbus, Ohio.

Submitted: August 11, 2023, Revised: October 24, 2023, Accepted: November 1, 2023, Published online: November 13, 2023.

This article was presented at the 82nd Annual Meeting of AAST in Anaheim, CA on September 20, 2023.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal’s Web site (www.jtrauma.com).

Address for correspondence: Carrie A. Sims, MD, PhD, Professor of Surgery, Division of Trauma, Critical Care, and Burn, The Ohio State University Wexner Medical Center, Room 654, Faculty Office Tower, 395 12th Ave, Columbus, OH 43210; email: [email protected].

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