Lai CC, Shih TP, Ko WC, Tang HJ, Hsueh PR. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. Int J Antimicrob Agents. 2022;55(3):105924.

Article  Google Scholar 

Pathania AS, Prathipati P, Abdul BA, Chava S, Katta SS, Gupta SC, Gangula PR, Pandey MK, Durden DL, Byrareddy SN, Challagundla KB. COVID-19 and cancer comorbidity: therapeutic opportunities and challenges. Theranostics. 2021;11(2):731–53. https://doi.org/10.7150/thno.51471. PMID: 33391502; PMCID: PMC7738845.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Passaro A, Bestvina C, Velez Velez M, Garassino MC, Garon E, Peters S. Severity of COVID-19 in patients with lung cancer: evidence and challenges. J Immunother Cancer. 2021;9(3):e002266.

Tian J, Yuan X, Xiao J, Zhong Q, Yang C, Liu B, Cai Y, Lu Z, Wang J, Wang Y, Liu S. Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study. Lancet Oncol. 2020;21(7):893–903.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chugh A, Sehgal I, Khurana N, Verma K, Rolta R, Vats P, Salaria D, Fadare OA, Awofisayo O, Verma A, Phartyal R. Comparative docking studies of drugs and phytocompounds for emerging variants of SARS-CoV-2. 3 Biotech. 2023;13(1):36.

Article  PubMed  PubMed Central  Google Scholar 

Sohrabi C, Alsafi Z, O’Neill N, Khan M, Kerwan A, Al-Jabir A, Iosifidis C, Agha R. World Health Organization declares global emergency: a review of the 2019 novel coronavirus (COVID-19). Int J Surg. 2020;76:71–6.

Article  PubMed  PubMed Central  Google Scholar 

Rome BN, Avorn J. Drug evaluation during the COVID-19 pandemic. N Engl J Med. 2020;382(24):2282–4.

Article  CAS  PubMed  Google Scholar 

Behl T, Rocchetti G, Chadha S, Zengin G, Bungau S, Kumar A, Mehta V, Uddin MS, Khullar G, Setia D, Arora S. Phytochemicals from plant foods as potential source of antiviral agents: an overview. Pharmaceuticals. 2021;14(4):381.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang F, Li Y, Leung EL, Liu X, Liu K, Wang Q, Lan Y, Li X, Yu H, Cui L, Luo H. A review of therapeutic agents and Chinese herbal medicines against SARS-COV-2 (COVID-19). Pharmacol res. 2020;1(158): 104929.

Article  Google Scholar 

Panyod S, Ho CT, Sheen LY. Dietary therapy and herbal medicine for COVID-19 prevention: a review and perspective. J Tradit Complement Med. 2020;10(4):420–7.

Article  PubMed  PubMed Central  Google Scholar 

Maphetu N, Unuofin JO, Masuku NP, Olisah C, Lebelo SL. Medicinal uses, pharmacological activities, phytochemistry, and the molecular mechanisms of Punica granatum L (pomegranate) plant extracts: a review. Biomed Pharmacother. 2022;153:113256.

Article  CAS  PubMed  Google Scholar 

Pienaar L, Barends-Jones V. The economic contribution of South Africa’s pomegranate industry. Agriprobe. 2021;18(4):57–64.

Google Scholar 

Mo Y, Ma J, Gao W, Zhang L, Li J, Li J, Zang J. Pomegranate peel as a source of bioactive compounds: a mini review on their physiological functions. Front Nutr. 2022;9:887113.

Article  PubMed  PubMed Central  Google Scholar 

Shaygannia E, Bahmani M, Zamanzad B, Rafieian-Kopaei M. A review study on Punica granatum L. J Evid Based Complement Altern Med. 2016;21(3):221–7.

Article  CAS  Google Scholar 

Salles TS, Meneses MDF, Caldas LA, Sá-Guimarães TE, de Oliveira DM, Ventura JA, Azevedo RC, Kuster RM, Soares MR, Ferreira DF. Virucidal and antiviral activities of pomegranate (Punica granatum) extract against the mosquito-borne Mayaro virus. Parasit Vectors. 2021;14(1):443.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Neurath AR, Strick N, Li YY, Debnath AK. Punica granatum (pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide. Ann N Y Acad Sci. 2005;1056:311–27.

Article  CAS  PubMed  Google Scholar 

Al-Zoreky NS. Antimicrobial activity of pomegranate (Punica granatum L.) fruit peels. Int J Food Microbiol. 2009;134(3):244–8.

Article  CAS  PubMed  Google Scholar 

Das S, Sarmah S, Lyndem S, Singha RA. An investigation into the identification of potential inhibitors of SARS-CoV-2 main protease using molecular docking study. J Biomol Struct Dyn. 2021;39(9):3347–57.

CAS  PubMed  Google Scholar 

Amin SA, Banerjee S, Ghosh K, Gayen S, Jha T. Protease targeted COVID-19 drug discovery and its challenges: Insight into viral main protease (Mpro) and papain-like protease (PLpro) inhibitors. Bioorg Med Chem. 2021;1(29):115860.

Article  Google Scholar 

Siddiqui S, Upadhyay S, Ahmad I, Hussain A, Ahamed M. Cytotoxicity of Moringa oleifera fruits on human liver cancer and molecular docking analysis of bioactive constituents against caspase-3 enzyme. J Food Biochem. 2021;45(5):e13720.

Article  CAS  PubMed  Google Scholar 

Siddiqui S, Ahmad E, Gupta M, Rawat V, Shivnath N, Banerjee M, Khan MS, Arshad M. Cissus quadrangularis Linn exerts dose-dependent biphasic effects: osteogenic and anti-proliferative, through modulating ROS, cell cycle and Runx2 gene expression in primary rat osteoblasts. Cell Prolif. 2015;48(4):443–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaleem S, Siddiqui S, Siddiqui HH, Badruddeen, Hussain A, Arshad M, Akhtar J, Rizvi A. Eupalitin induces apoptosis in prostate carcinoma cells through ROS generation and increase of caspase-3 activity. Cell Biol Int. 2016;40(2):196–203.

Article  CAS  PubMed  Google Scholar 

Sahayarayan JJ, Rajan KS, Vidhyavathi R, Nachiappan M, Prabhu D, Alfarraj S, Arokiyaraj S, Daniel AN. In-silico protein-ligand docking studies against the estrogen protein of breast cancer using pharmacophore based virtual screening approaches. Saudi J Biol Sci. 2021;28(1):400–7.

Article  CAS  PubMed  Google Scholar 

Owoloye AJ, Ligali FC, Enejoh OA, Musa AZ, Aina O, Idowu ET, Oyebola KM. Molecular docking, simulation and binding free energy analysis of small molecules as Pf HT1 inhibitors. PLoS ONE. 2022;17(8):e0268269.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Culletta G, Gulotta MR, Perricone U, Zappalà M, Almerico AM, Tutone M. Exploring the SARS-CoV-2 proteome in the search of potential inhibitors via structure-based pharmacophore modeling/docking approach. Computation. 2020;8(3):77.

Article  CAS  Google Scholar 

Siddique F, Anwaar A, Bashir M, Nadeem S, Rawat R, Eyupoglu V, Afzal S, Bibi M, Bin Jardan YA, Bourhia M. Revisiting methotrexate and phototrexate Zinc15 library-based derivatives using deep learning in-silico drug design approach. Front Chem. 2024;21(12):1380266.

Article  Google Scholar 

Ribeiro R, Botelho FD, Pinto AMV, La Torre AMA, Almeida JSFD, LaPlante SR, Franca TCC, Veiga-Junior VF, Dos Santos MC. Molecular modeling study of natural products as potential bioactive compounds against SARS-CoV-2. J Mol Model. 2023;29(6):183.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lipinski CA. Lead- and drug-like compounds: the rule-of-five revolution. Drug Discov Today Technol. 2004;1(4):337–41.

Article  CAS  PubMed  Google Scholar 

Popova M, Dimitrova R, Al-Lawati HT, Tsvetkova I, Najdenski H, Bankova V. Omani propolis: chemical profiling, antibacterial activity and new propolis plant sources. Chem Cent J. 2013;7(1):158.

Article  PubMed  PubMed Central  Google Scholar 

Villas-Bôas SG, Mas S, Akesson M, Smedsgaard J, Nielsen J. Mass spectrometry in metabolome analysis. Mass Spectrom Rev. 2005;24(5):613–46.

Article  PubMed  Google Scholar 

Singh G, Lu D, Liu C, Hower D. Analytical challenges and recent advances in the identification and quantitation of extractables and leachables in pharmaceutical and medical products. TrAC - Trends Anal Chem. 2021;1(141):116286.

Article  Google Scholar 

El-Missiry MA, Fekri A, Kesar LA, Othman AI. Polyphenols are potential nutritional adjuvants for targeting COVID-19. Phytother Res. 2021;35(6):2879–89.

Article