GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axis

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin. 2017;67(1):7–30.

Curigliano G, Burstein HJ, Winer P, Gnant M, Dubsky P, Loibl S, et al. De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the primary therapy of early breast Cancer 2017. Ann Oncol. 2017;28(8):1700–12.

Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A. 2001;98(19):10869–74.

Article  PubMed  PubMed Central  Google Scholar 

Hirshfield KM, Ganesan S. Triple-negative breast cancer: molecular subtypes and targeted therapy. Curr Opin Obstet Gynecol. 2014;26(1):34–40.

Article  PubMed  Google Scholar 

Lefkowitz RJ. Seven transmembrane receptors: something old, something new. Acta Physiol (Oxf). 2007;190(1):9–19.

Article  PubMed  Google Scholar 

Lefkowitz RJ, Shenoy SK. Transduction of receptor signals by beta-arrestins. Science. 2005;308(5721):512–7.

Article  PubMed  Google Scholar 

Pitcher JA, Freedman NJ, Lefkowitz RJ. G protein-coupled receptor kinases. Annu Rev Biochem. 1998;67:653–92.

Article  PubMed  Google Scholar 

Nobles KN, Xiao K, Ahn S, Shukla AK, Lam CM, Rajagopal S, et al. Distinct phosphorylation sites on the beta(2)-adrenergic receptor establish a barcode that encodes differential functions of beta-arrestin. Sci Signal. 2011;4(185):ra51.

Article  PubMed  PubMed Central  Google Scholar 

Nakai A, Fujimoto J, Miyata H, Stumm R, Narazaki M, Schulz S, et al. The COMMD3/8 complex determines GRK6 specificity for chemoattractant receptors. J Exp Med. 2019;216(7):1630–47.

Article  PubMed  PubMed Central  Google Scholar 

Tao R, Li Q, Gao X, Ma L. Overexpression of GRK6 associates with the progression and prognosis of colorectal carcinoma. Oncol Lett. 2018;15(4):5879–86.

PubMed  PubMed Central  Google Scholar 

Che X, Zhang G, Zhang X, Xue J. Overexpression of G protein-coupled receptor kinase 6 (GRK6) is Associated with Progression and poor prognosis of papillary thyroid carcinoma. Med Sci Monit. 2018;24:3540–8.

Article  PubMed  PubMed Central  Google Scholar 

Li YP. GRK6 expression in patients with hepatocellular carcinoma. Asian Pac J Trop Med. 2013;6(3):220–3.

Article  PubMed  Google Scholar 

Yuan L, Zhang H, Liu J, Rubin JB, Cho YJ, Shu HK, et al. Growth factor receptor-src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes medulloblastoma migration. Mol Cancer. 2013;12:18.

Article  PubMed  PubMed Central  Google Scholar 

Raghuwanshi SK, Smith N, Rivers EJ, Thomas AJ, Sutton N, Hu Y, et al. G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. J Immunol. 2013;190(10):5329–36.

Article  PubMed  Google Scholar 

Yao S, Wu D, Chen J, Wang P, Lv X, Huang J. Hypermethylation of the G protein-coupled receptor kinase 6 (GRK6) promoter inhibits binding of C/EBPalpha, and GRK6 knockdown promotes cell migration and invasion in lung adenocarcinoma cells. FEBS Open Bio. 2019;9(4):605–17.

Article  PubMed  PubMed Central  Google Scholar 

Yao S, Zhong L, Liu J, Feng J, Bian T, Zhang Q, et al. Prognostic value of decreased GRK6 expression in lung adenocarcinoma. J Cancer Res Clin Oncol. 2016;142(12):2541–9.

Article  PubMed  Google Scholar 

Nogues L, Reglero C, Rivas V, Salcedo A, Lafarga V, Neves M, et al. G protein-coupled receptor kinase 2 (GRK2) promotes breast tumorigenesis through a HDAC6-Pin1 Axis. EBioMedicine. 2016;13:132–45.

Article  PubMed  PubMed Central  Google Scholar 

Billard MJ, Fitzhugh DJ, Parker JS, Brozowski JM, McGinnis MW, Timoshchenko RG, et al. G Protein Coupled Receptor Kinase 3 regulates breast Cancer Migration, Invasion, and Metastasis. PLoS ONE. 2016;11(4):e0152856.

Article  PubMed  PubMed Central  Google Scholar 

Matsubayashi J, Takanashi M, Oikawa K, Fujita K, Tanaka M, Xu M, et al. Expression of G protein-coupled receptor kinase 4 is associated with breast cancer tumourigenesis. J Pathol. 2008;216(3):317–27.

Article  PubMed  Google Scholar 

Stoffel RH, Inglese J, Macrae AD, Lefkowitz RJ, Premont RT. Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6. Biochemistry. 1998;37(46):16053–9.

Article  PubMed  Google Scholar 

Beautrait A, Paradis JS, Zimmerman B, Giubilaro J, Nikolajev L, Armando S, et al. A new inhibitor of the beta-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling. Nat Commun. 2017;8:15054.

Article  PubMed  PubMed Central  Google Scholar 

Nguyen HT, Reyes-Alcaraz A, Yong HJ, Nguyen LP, Park HK, Inoue A, et al. CXCR7: a beta-arrestin-biased receptor that potentiates cell migration and recruits beta-arrestin2 exclusively through gbetagamma subunits and GRK2. Cell Biosci. 2020;10(1):134.

Article  PubMed  PubMed Central  Google Scholar 

Huber MA, Azoitei N, Baumann B, Grunert S, Sommer A, Pehamberger H, et al. NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest. 2004;114(4):569–81.

Article  PubMed  PubMed Central  Google Scholar 

Huang SP, Liu PY, Kuo CJ, Chen CL, Lee WJ, Tsai YH, et al. The Gαh-PLCδ1 signaling axis drives metastatic progression in triple-negative breast cancer. J Hematol Oncol. 2017;10(1):114.

Article  PubMed  PubMed Central  Google Scholar 

Duan L, Duan D, Wei W, Sun Z, Xu H, Guo L, et al. MiR-19b-3p attenuates IL-1β induced extracellular matrix degradation and inflammatory injury in chondrocytes by targeting GRK6. Mol Cell Biochem. 2019;459(1–2):205–14.

Article  PubMed  Google Scholar 

Firsov D, Elalouf JM. Molecular cloning of two rat GRK6 splice variants. Am J Physiol. 1997;273(3 Pt 1):C953–61.

Article  PubMed  Google Scholar 

Uehling DE, Joseph B, Chung KC, Zhang AX, Ler S, Prakesch MA, et al. Design, synthesis, and characterization of 4-Aminoquinazolines as potent inhibitors of the G protein-coupled receptor kinase 6 (GRK6) for the treatment of multiple myeloma. J Med Chem. 2021;64(15):11129–47.

Article  PubMed  Google Scholar 

Jing X, Zhang H, Hu J, Su P, Zhang W, Jia M, et al. beta-arrestin 2 is associated with multidrug resistance in breast cancer cells through regulating MDR1 gene expression. Int J Clin Exp Pathol. 2015;8(2):1354–63.

PubMed  PubMed Central  Google Scholar 

Qiu N, Jin H, Cui L, Zhan YT, Xia HM, Jiang M, et al. IFT20 confers Paclitaxel Resistance by triggering beta-arrestin-1 to modulate ASK1 signaling in breast Cancer. Mol Cancer Res. 2023;21(3):214–27.

Article  PubMed  Google Scholar 

Donia T, Abouda M, Kelany M, Hessien M. beta-arrestin inhibition induces autophagy, apoptosis, G0/G1 cell cycle arrest in agonist-activated V2R receptor in breast cancer cells. Med Oncol. 2021;38(4):38.

Article  PubMed  Google Scholar 

Ge L, Shenoy SK, Lefkowitz RJ, DeFea K. Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and – 2. J Biol Chem. 2004;279(53):55419–24.

Article  PubMed  Google Scholar 

Lundgren K, Tobin NP, Lehn S, Stal O, Ryden L, Jirstrom K, et al. Stromal expression of beta-arrestin-1 predicts clinical outcome and tamoxifen response in breast cancer. J Mol Diagn. 2011;13(3):340–51.

Article  PubMed  PubMed Central  Google Scholar 

Dong C, Li Y, Niu Q, Fang H, Bai J, Yan Y, et al. SUMOylation involves in beta-arrestin-2-dependent metabolic regulation in breast cancer cell. Biochem Biophys Res Commun. 2020;529(4):950–6.

Article  PubMed  Google Scholar 

Shiraki A, Shimizu S. The molecular associations in clathrin-coated pit regulate beta-arrestin-mediated MAPK signaling downstream of mu-opioid receptor. Biochem Biophys Res Commun. 2023;640:64–72.

Article  PubMed  Google Scholar 

Azzi M, Charest PG, Angers S, Rousseau G, Kohout T, Bouvier M, et al. Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. Proc Natl Acad Sci U S A. 2003;100(20):11406–11.

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