Masahiro Shiokawa received patent royalties and research grants from Medical and Biological Laboratories Co., Ltd. Tadakazu Hisamatsu received consulting fees from Mitsubishi Tanabe Pharma Co., EA Pharma Co., Abbvie GK., Janssen Pharmaceutical K.K, Nichi-Iko Pharmaceutical Co., Ltd., Eli Lilly, and Gilead Sciences Inc., honorariums from Mitsubishi Tanabe Pharma Co., Abbvie GK., EA Pharma Co., Kyorin Pharmaceutical Co., Ltd., JIMRO Co., Ltd., Janssen Pharmaceutical K.K, Mochida Pharmaceutical Co., Ltd., Takeda Pharmaceutical Co., Ltd., Pfizer Inc., and Kissei Pharmaceutical Co., Ltd., and research grants from EA Pharma Co., Abbvie GK., Pfizer Inc., Mitsubishi Tanabe Pharma Co., Kyorin Pharmaceutical Co., Ltd., JIMRO Co., Ltd., Mochida Pharmaceutical Co., Ltd., Daiichi-Sankyo Co., Ltd., Takeda Pharmaceutical Co., Ltd., Zeria Pharmaceutical Co., Ltd., Nippon Kayaku Co. Ltd., and Boston Scientific Corporation. Hajime Yamazaki received research grants from Takeda Pharmaceutical Co., Ltd. Aki Sakatani received endowed chair from Toukeikai Kyoritsu Hospital. Toshimitsu Fujii received honorariums from Abbvie GK., Janssen Pharmaceutical K.K, Mitsubishi Tanabe Pharma Co. and Takeda Pharmaceutical Co., Ltd., and research grants from Abbvie GK., Alfresa Pharma Co., Boehringer Ingelheim co., Bristol-Myers Squibb, Celgene Inc., Celltrion Inc., EA Pharma Co., Eli Lilly Japan K.K., Gilead Sciences Inc., Janssen Pharmaceutical KK., Kissei Pharmaceutical Co., Ltd., Mebix Inc., Sanofi Ltd., and Takeda Pharmaceutical Co., Ltd. Minoru Matsuura received honorariums from Janssen Pharmaceutical K.K., and Abbvie GK. Reiko Kunisaki received honorariums from Abbvie GK., Janssen Pharmaceutical K.K, Mitsubishi Tanabe Pharma Co., and Takeda Pharmaceutical Co., Ltd., and research grants from Eli Lilly Japan K.K., Janssen Pharmaceutical K.K, and Takeda Pharmaceutical Co., Ltd. Tomohisa Takagi received honorariums from Janssen Pharmaceutical K.K, Mitsubishi Tanabe Pharma Co., Towa Pharmaceutical Co., Mochida Pharmaceutical Co., Ltd., Takeda Pharmaceutical Co., Ltd., Abbvie GK., EA Pharma Co., Ltd., and Pfizer Japan Inc., research grants from PreMedia Inc., and scholarship grants from Mitsubishi Tanabe Pharma Co. Tetsuo Takehara received honorariums from Abbvie GK., Gilead Sciences Inc., research grants from Gilead Sciences Inc., Janssen Pharmaceutical K.K, and scholarship grants from Abbvie GK., EA Pharma Co., Ltd., Mochida Pharmaceutical Co., Ltd., Daiichi-Sankyo Co., Ltd., and Nippon Kayaku Co., Ltd. Fumihito Hirai received honorariums from Abbvie GK., EA Pharma Co., Ltd., Janssen Pharmaceutical K.K, Mochida Pharmaceutical Co., Ltd., Mitsubishi Tanabe Pharma Co., and Takeda Pharmaceutical Co., Ltd., research grants from Eli Lilly Japan K.K., Janssen Pharmaceutical K.K, and Abbvie GK., and scholarship grants from Abbvie GK., EA Pharma Co., Ltd., Otsuka Pharmaceutical Co., Ltd., Kyorin Pharmaceutical Co., Ltd., Mochida Pharmaceutical Co., Ltd., and Mitsubishi Tanabe Pharma Co. Motohiro Esaki received honorariums from Abbvie GK., Mitsubishi Chemical Group Co., EA Pharma Co., Ltd., Janssen Pharmaceutical K.K, Takeda Pharmaceutical Co., Ltd., and Pfizer Japan Inc. Hiroshi Nakase received honorariums from Abbvie GK., Takeda Pharmaceutical Co., Ltd., Mitsubishi Tanabe Pharma Co., Janssen Pharmaceutical K.K, Gilead Sciences Inc., Pfizer Inc., EA Pharma Co., Ltd., Mochida Pharmaceutical Co., Ltd., VIATRIS Inc, and JIMRO Co., Ltd., research grants from Abbvie GK. and Hoya group Pentax Medical, scholarship grants from Nippon Kayaku Co., Mochida Pharmaceutical Co., Ltd., Kyorin Pharmaceutical Co., Ltd., Zeria Pharmaceutical Co., Ltd., Mitsubishi Tanabe Pharma Co. and EA Pharma Co., Ltd., and endowed chair from Miyarisan Pharmaceutical Co., Ltd., JIMRO Co., Ltd., Mochida Pharmaceutical Co., Ltd., and Kyorin Pharmaceutical Co., Ltd. Katsuyoshi Matsuoka received honorariums from Mitsubishi Tanabe Pharma Co., Takeda Pharmaceutical Co., Ltd., Janssen Pharmaceutical K.K., Abbvie GK, EA Pharma Co., Ltd., Pfizer Inc., Mochida Pharmaceutical Co., Ltd., Kissei Pharmaceutical Co., Ltd., Gilead Sciences, and Eli Lilly Japan K.K., research grants from Janssen Pharmaceutical K.K., and scholarship grants from Mochida Pharmaceutical Co., Ltd. and EA Pharma Co., Ltd. Kaoru Yokoyama received honorariums from Abbvie GK, EA Pharma Co., Ltd., Gilead Sciences Inc., and Takeda Pharmaceutical Co., Ltd. Makoto Naganuma received honorariums from EA Pharma Co., Ltd., Kyorin Pharmaceutical Co., Ltd., Mitsubishi Tanabe Pharma Co., Mochida Pharmaceutical Co., Ltd., Janssen Pharmaceutical KK., Abbvie GK., JIMRO Co., Ltd., Pfizer Inc., Gilead Sciences Inc., and Takeda Pharmaceutical Co., Ltd., research grants from Kyorin Pharmaceutical Co., Ltd. Mitsubishi Tanabe Pharma Co., Abbvie GK., and Miyarisan Pharmaceutical Co., Ltd., and fees paid for writing a pamphlet from Alfresa Pharma Co. Ltd., Masayuki Saruta received honorariums from Abbvie GK., Takeda Pharmaceutical Co., Ltd., EA Pharma Co., Ltd., Mochida Pharmaceutical Co., Ltd., Mitsubishi Tanabe Pharma Co., Gilead Sciences Inc., Janssen Pharmaceutical K.K, Kissei Pharmaceutical Co., Ltd., Viatris Pharmaceutical Co., Ltd., and Nobel Pharma Co. Ltd., research grants from Abbvie GK. CMO Co. Ltd. and PPD-SNBL KK., and scholarship grants from Abbvie GK., Zeria Pharmaceutical Co., Ltd., Mochida Pharmaceutical Co., Ltd., and Kissei Pharmaceutical Co., Ltd. Hiroshi Seno received honorariums from Eisai Co., Ltd., and scholarship grants from Mitsubishi Tanabe Pharma Co. All other authors have no conflicts of interest.