Hiromu Morikubo has received grant support from Takeda Pharmaceutical. Minoru Matsuura has received consulting and lecture fees from Janssen Pharmaceutical K.K., Takeda Pharmaceutical Co. Ltd., AbbVie GK, Mitsubishi Tanabe Pharma Corporation, Kyorin Pharmaceutical Co. Ltd., Mochida Pharmaceutical Co., Ltd., JIMRO Co., Nippon Kayaku Co. Ltd., Mylan EPD G.K., and Aspen Japan Co. Ltd. Jun Miyoshi has received grant support from AbbVie GK, and consulting and lecture fees from EA Pharma Co. Ltd., AbbVie GK, Janssen Pharmaceutical K.K., Jansen Asia Pacific Pte. Ltd., Pfizer Inc., Mitsubishi Tanabe Pharma Corporation, JIMRO Co., Miyarisan Co. Ltd., and Takeda Pharmaceutical Co. Ltd. Tadakazu Hisamatsu has performed Joint Research with Kissei Pharmaceutical Co., Ltd. and EA Pharma Co., Ltd. and received grant support from Mitsubishi Tanabe Pharma Corporation, EA Pharma Co., Ltd., AbbVie GK, JIMRO Co., Ltd., Zeria Pharmaceutical Co., Ltd., Kyorin Pharmaceutical Co., Ltd., Nippon Kayaku Co., Ltd., Takeda Pharmaceutical Co., Ltd., Pfizer Inc., Boston Scientific Corporation, and Mochida Pharmaceutical Co., Ltd. as well as consulting and lecture fees from EA Pharma Co., Ltd., AbbVie GK, Janssen Pharmaceutical K.K., Pfizer Inc., Mitsubishi Tanabe Pharma Corporation, Kyorin Pharmaceutical Co., Ltd., JIMRO Co., Mochida Pharmaceutical Co., Ltd., Bristol Myers Squibb Co., Eli Lilly and Company, Gilead Sciences, Inc., and Takeda Pharmaceutical Co., Ltd. Haruka Komatsu, Yoko Kimura, Chihiro Moue, and Hiromi Yonezawa have no conflicts of interest to declare.