Darby, I. 2000. 2022 Risk factors for periodontitis & peri-implantitis. Periodontol 90 (1): 9–12.

Article  Google Scholar 

Sato, M., M. Iwasaki, A. Yoshihara, and H. Miyazaki. 2016. Association between periodontitis and medical expenditure in older adults: A 33-month follow-up study. Geriatr Gerontol Int 16 (7): 856–864.

Article  PubMed  Google Scholar 

Li, C., H. Zhou, H. Gou, et al. 2024. Autoinducer-2 produced by oral microbial flora and alveolar bone loss in periodontitis. Journal of Periodontal Research 59 (3): 576–588.

Article  PubMed  CAS  Google Scholar 

Papenfort, Kai, and Bonnie L. Bassler. 2016. Quorum sensing signal-response systems in Gram-negative bacteria. Nature reviews Microbiology 14: 576–88.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Xavier, Karina B., and Bonnie L. Bassler. 2005. Interference with AI-2-mediated bacterial cell-cell communication. Nature 437 (7059): 750–3.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Blackwell, Helen E., and Clay Fuqua. 2011. Introduction to bacterial signals and chemical communication. Chemical reviews 111: 1–3.

Article  PubMed  CAS  Google Scholar 

Laganenka, Leanid, et al. 2023. Chemotaxis and autoinducer-2 signalling mediate colonization and contribute to co-existence of Escherichia coli strains in the murine gut. Nature microbiology 8: 204–217.

Article  PubMed  CAS  Google Scholar 

Li, Qing et al. “Autoinducer-2 of gut microbiota, a potential novel marker for human colorectal cancer, is associated with the activation of TNFSF9 signaling in macrophages.” Oncoimmunology vol. 8,10 e1626192. 10 Jun. 2019

Wu, Jiao, et al. 2020. Immune induction identified by TMT proteomics analysis in Fusobacterium nucleatum autoinducer-2 treated macrophages. Expert review of proteomics 17 (2): 175–185.

Article  PubMed  CAS  Google Scholar 

Netea, Mihai G., et al. 2017. A guiding map for inflammation. Nature immunology 18 (8): 826–831.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Locati, Massimo, et al. 2020. Diversity, Mechanisms, and Significance of Macrophage Plasticity. Annual review of pathology 15: 123–147.

Article  PubMed  CAS  Google Scholar 

Huang, Yanlan et al. “TET1 Knockdown Inhibits Porphyromonas gingivalis LPS/IFN-γ-Induced M1 Macrophage Polarization through the NF-κB Pathway in THP-1 Cells.” International journal of molecular sciences vol. 20,8 2023. 24 Apr. 2019

Bassler, B.L., et al. 1993. Intercellular signalling in Vibrio harveyi: Sequence and function of genes regulating expression of luminescence. Molecular microbiology 9 (4): 773–786.

Article  PubMed  CAS  Google Scholar 

Marchesan, Julie, et al. 2018. An experimental murine model to study periodontitis. Nature protocols 13 (10): 2247–2267.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Charan, Jaykaran, and N.D. Kantharia. 2013. How to calculate sample size in animal studies? Journal of pharmacology & pharmacotherapeutics 4 (4): 303–6.

Article  Google Scholar 

Mann, Mati, et al. 2017. An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses. Nature communications 8 (1): 851.

Article  PubMed  PubMed Central  Google Scholar 

Cheng, Quen J., et al. 2021. NF-κB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages. Science (New York, N.Y.) 372 (6548): 1349–1353.

Article  PubMed  CAS  Google Scholar 

Bakaletz, L.O., B.D. Baker, J.A. Jurcisek, et al. 2005. Demonstration of Type IV pilus expression and a twitching phenotype by Haemophilus influenzae. Infection and Immunity 73 (3): 1635–1643.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yu, Y., S. Zhu, P. Li, L. Min, and S. Zhang. 2018. Helicobacter pylori infection and inflammatory bowel disease: A crosstalk between upper and lower digestive tract. Cell Death & Disease 9 (10): 961.

Article  Google Scholar 

Ji, Y.C., Q. Sun, C.Y. Fu, et al. 2021. Exogenous Autoinducer-2 Rescues Intestinal Dysbiosis and Intestinal Inflammation in a Neonatal Mouse Necrotizing Enterocolitis Model. Frontiers in Cellular and Infection Microbiology 11: 694395.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Schauder, S., K. Shokat, M.G. Surette, and B.L. Bassler. 2001. The LuxS family of bacterial autoinducers: Biosynthesis of a novel quorum-sensing signal molecule. Molecular Microbiology 41 (2): 463–476.

Article  PubMed  CAS  Google Scholar 

Bin Mohammad Muzaki, M.Z., S. Subramoni, S. Summers, S. Kjelleberg, and S.A. Rice. 2024. Klebsiella pneumoniae AI-2 transporters mediate interspecies interactions and composition in a three-species biofilm community. NPJ Biofilms Microbiomes. 10 (1): 91.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sun, Q., Y.C. Ji, Q. Ai, et al. 2024. Exogenous autoinducer-2 alleviates intestinal damage in necrotizing enterocolitis via PAR2/MMP3 signaling pathway. International Immunopharmacology 138: 112567.

Article  PubMed  CAS  Google Scholar 

Du, X., Z. Tang, L. Yan, et al. 2024. Norepinephrine may promote the progression of Fusobacterium nucleatum related colorectal cancer via quorum sensing signalling. Virulence. 15 (1): 2350904.

Article  PubMed  PubMed Central  Google Scholar 

Hu, R., T. Yang, Q. Ai, et al. 2024. Autoinducer-2 promotes the colonization of Lactobacillus rhamnosus GG to improve the intestinal barrier function in a neonatal mouse model of antibiotic-induced intestinal dysbiosis. Journal of Translational Medicine 22 (1): 177.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wang J, Yang J, Durairaj P, et al. Discovery of β-nitrostyrene derivatives as potential quorum sensing inhibitors for biofilm inhibition and antivirulence factor therapeutics against Serratia marcescens. mLife. 2024;3(3):445–458

Chen, Yongcheng, et al. 2023. Inhibiting Quorum Sensing by Active Targeted pH-Sensitive Nanoparticles for Enhanced Antibiotic Therapy of Biofilm-Associated Bacterial Infections. ACS nano 17 (11): 10019–10032.

Article  PubMed  CAS  Google Scholar 

Yan, Na., et al. 2022. Penetrating Macrophage-Based Nanoformulation for Periodontitis Treatment. ACS nano 16 (11): 18253–18265.

Article  PubMed  CAS  Google Scholar 

Tonetti, Maurizio S., et al. 2018. Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. Journal of clinical periodontology 45: S149–S161.

Article  PubMed  Google Scholar