Transcriptional regulation by MYC: an emerging new model

Colby WW, Chen EY, Smith DH, Levinson AD. Identification and nucleotide sequence of a human locus homologous to the v-myc oncogene of avian myelocytomatosis virus MC29. Nature. 1983;301:722–5.

Article  CAS  PubMed  Google Scholar 

Dang CV. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol. 1999;19:1–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dang CV. MYC on the path to cancer. Cell. 2012;149:22–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adams JM, Harris AW, Pinkert CA, Corcoran LM, Alexander WS, Cory S, et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature. 1985;318:533–8.

Article  CAS  PubMed  Google Scholar 

Gurel B, Iwata T, Koh CM, Jenkins RB, Lan F, Van Dang C, et al. Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis. Mod Pathol. 2008;21:1156–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Llombart V, Mansour MR. Therapeutic targeting of “undruggable” MYC. EBioMedicine. 2022;75:103756.

Article  CAS  PubMed  Google Scholar 

Wang C, Zhang J, Yin J, Gan Y, Xu S, Gu Y, et al. Alternative approaches to target Myc for cancer treatment. Signal Transduct Target Ther. 2021;6:117.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garralda E, Beaulieu M-E, Moreno V, Casacuberta-Serra S, Martínez-Martín S, Foradada L, et al. MYC targeting by OMO-103 in solid tumors: a phase 1 trial. Nat Med. 2024;30:762–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dominguez-Sola D, Ying CY, Grandori C, Ruggiero L, Chen B, Li M, et al. Non-transcriptional control of DNA replication by c-Myc. Nature. 2007;448:445–51.

Article  CAS  PubMed  Google Scholar 

Dunn S, Cowling VH. Myc and mRNA capping. Biochim Biophys Acta. 2015;1849:501–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Soucek L, Whitfield J, Martins CP, Finch AJ, Murphy DJ, Sodir NM, et al. Modelling Myc inhibition as a cancer therapy. Nature. 2008;455:679–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang E, Sorolla A, Cunningham PT, Bogdawa HM, Beck S, Golden E, et al. Tumor penetrating peptides inhibiting MYC as a potent targeted therapeutic strategy for triple-negative breast cancers. Oncogene. 2019;38:140–50.

Article  CAS  PubMed  Google Scholar 

Blackwood EM, Eisenman RN. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science. 1991;251:1211–7.

Article  CAS  PubMed  Google Scholar 

Kalkat M, Resetca D, Lourenco C, Chan P-K, Wei Y, Shiah Y-J, et al. MYC protein interactome profiling reveals functionally distinct regions that cooperate to drive tumorigenesis. Mol Cell. 2018;72:836–48.e837.

Article  CAS  PubMed  Google Scholar 

Lin CY, Lovén J, Rahl PB, Paranal RM, Burge CB, Bradner JE. et al. Transcriptional amplification in tumor cells with elevated c-Myc. Cell. 2012;151:56–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nie Z, Hu G, Wei G, Cui K, Yamane A, Resch W. et al. c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell. 2012;151:68–79.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sabò A, Kress TR, Pelizzola M, de Pretis S, Gorski MM, Tesi A, et al. Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis. Nature. 2014;511:488–92.

Article  PubMed  PubMed Central  Google Scholar 

Fernandez PC, Frank SR, Wang L, Schroeder M, Liu S, Greene J, et al. Genomic targets of the human c-Myc protein. Genes Dev. 2003;17:1115–29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guccione E, Martinato F, Finocchiaro G, Luzi L, Tizzoni L, Dall’ Olio V. et al. Myc-binding-site recognition in the human genome is determined by chromatin context. Nature Cell Biology. 2006;8:764–770.

Article  CAS  PubMed  Google Scholar 

Soufi A, Donahue G, Zaret KS. Facilitators and impediments of the pluripotency reprogramming factors’ initial engagement with the genome. Cell. 2012;151:994–1004.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zeid R, Lawlor MA, Poon E, Reyes JM, Fulciniti M, Lopez MA, et al. Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma. Nat Genet. 2018;50:515–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jakobsen ST, Jensen RAM, Madsen MS, Ravnsborg T, Vaagenso CS, Siersbæk MS, et al. MYC activity at enhancers drives prognostic transcriptional programs through an epigenetic switch. Nat Genet. 2024;56:663–74.

Article  CAS  PubMed  Google Scholar 

Guo J, Li T, Schipper J, Nilson KA, Fordjour FK, Cooper JJ, et al. Sequence specificity incompletely defines the genome-wide occupancy of Myc. Genome Biol. 2014;15:482.

Article  PubMed  PubMed Central  Google Scholar 

Sabò A, Amati B. Genome recognition by MYC. Cold Spring Harb Perspect Med. 2014;4:a014191.

Article  PubMed  PubMed Central  Google Scholar 

Walz S, Lorenzin F, Morton J, Wiese KE, von Eyss B, Herold S, et al. Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles. Nature. 2014;511:483–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boija A, Klein IA, Sabari BR, Dall’Agnese A, Coffey EL, Zamudio AV, et al. Transcription factors activate genes through the phase-separation capacity of their activation domains. Cell. 2018;175:1842–55.e1816.

Article  CAS  PubMed  Google Scholar 

Yang J, Chung C-I, Koach J, Liu H, Navalkar A, He H, et al. MYC phase separation selectively modulates the transcriptome. Nat Struct Mol Biol. 2024;1–13.

Pellanda P, Dalsass M, Filipuzzi M, Loffreda A, Verrecchia A, Castillo Cano V, et al. Integrated requirement of non-specific and sequence-specific DNA binding in Myc-driven transcription. EMBO J. 2021;40:e105464.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dang CV, O’Donnell KA, Zeller KI, Nguyen T, Osthus RC, Li F. The c-Myc target gene network. Semin Cancer Biol. 2006;16:253–64.

Article  CAS  PubMed  Google Scholar 

Lewis LM, Edwards MC, Meyers ZR, Talbot CC Jr., Hao H, Blum D, et al. Replication study: transcriptional amplification in tumor cells with elevated c-Myc. eLife. 2018;7:e30274.

Article  PubMed  PubMed Central  Google Scholar 

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