Colby WW, Chen EY, Smith DH, Levinson AD. Identification and nucleotide sequence of a human locus homologous to the v-myc oncogene of avian myelocytomatosis virus MC29. Nature. 1983;301:722–5.
Article CAS PubMed Google Scholar
Dang CV. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol. 1999;19:1–11.
Article CAS PubMed PubMed Central Google Scholar
Dang CV. MYC on the path to cancer. Cell. 2012;149:22–35.
Article CAS PubMed PubMed Central Google Scholar
Adams JM, Harris AW, Pinkert CA, Corcoran LM, Alexander WS, Cory S, et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature. 1985;318:533–8.
Article CAS PubMed Google Scholar
Gurel B, Iwata T, Koh CM, Jenkins RB, Lan F, Van Dang C, et al. Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis. Mod Pathol. 2008;21:1156–67.
Article CAS PubMed PubMed Central Google Scholar
Llombart V, Mansour MR. Therapeutic targeting of “undruggable” MYC. EBioMedicine. 2022;75:103756.
Article CAS PubMed Google Scholar
Wang C, Zhang J, Yin J, Gan Y, Xu S, Gu Y, et al. Alternative approaches to target Myc for cancer treatment. Signal Transduct Target Ther. 2021;6:117.
Article CAS PubMed PubMed Central Google Scholar
Garralda E, Beaulieu M-E, Moreno V, Casacuberta-Serra S, Martínez-Martín S, Foradada L, et al. MYC targeting by OMO-103 in solid tumors: a phase 1 trial. Nat Med. 2024;30:762–71.
Article CAS PubMed PubMed Central Google Scholar
Dominguez-Sola D, Ying CY, Grandori C, Ruggiero L, Chen B, Li M, et al. Non-transcriptional control of DNA replication by c-Myc. Nature. 2007;448:445–51.
Article CAS PubMed Google Scholar
Dunn S, Cowling VH. Myc and mRNA capping. Biochim Biophys Acta. 2015;1849:501–5.
Article CAS PubMed PubMed Central Google Scholar
Soucek L, Whitfield J, Martins CP, Finch AJ, Murphy DJ, Sodir NM, et al. Modelling Myc inhibition as a cancer therapy. Nature. 2008;455:679–83.
Article CAS PubMed PubMed Central Google Scholar
Wang E, Sorolla A, Cunningham PT, Bogdawa HM, Beck S, Golden E, et al. Tumor penetrating peptides inhibiting MYC as a potent targeted therapeutic strategy for triple-negative breast cancers. Oncogene. 2019;38:140–50.
Article CAS PubMed Google Scholar
Blackwood EM, Eisenman RN. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science. 1991;251:1211–7.
Article CAS PubMed Google Scholar
Kalkat M, Resetca D, Lourenco C, Chan P-K, Wei Y, Shiah Y-J, et al. MYC protein interactome profiling reveals functionally distinct regions that cooperate to drive tumorigenesis. Mol Cell. 2018;72:836–48.e837.
Article CAS PubMed Google Scholar
Lin CY, Lovén J, Rahl PB, Paranal RM, Burge CB, Bradner JE. et al. Transcriptional amplification in tumor cells with elevated c-Myc. Cell. 2012;151:56–67.
Article CAS PubMed PubMed Central Google Scholar
Nie Z, Hu G, Wei G, Cui K, Yamane A, Resch W. et al. c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell. 2012;151:68–79.
Article CAS PubMed PubMed Central Google Scholar
Sabò A, Kress TR, Pelizzola M, de Pretis S, Gorski MM, Tesi A, et al. Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis. Nature. 2014;511:488–92.
Article PubMed PubMed Central Google Scholar
Fernandez PC, Frank SR, Wang L, Schroeder M, Liu S, Greene J, et al. Genomic targets of the human c-Myc protein. Genes Dev. 2003;17:1115–29.
Article CAS PubMed PubMed Central Google Scholar
Guccione E, Martinato F, Finocchiaro G, Luzi L, Tizzoni L, Dall’ Olio V. et al. Myc-binding-site recognition in the human genome is determined by chromatin context. Nature Cell Biology. 2006;8:764–770.
Article CAS PubMed Google Scholar
Soufi A, Donahue G, Zaret KS. Facilitators and impediments of the pluripotency reprogramming factors’ initial engagement with the genome. Cell. 2012;151:994–1004.
Article CAS PubMed PubMed Central Google Scholar
Zeid R, Lawlor MA, Poon E, Reyes JM, Fulciniti M, Lopez MA, et al. Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma. Nat Genet. 2018;50:515–23.
Article CAS PubMed PubMed Central Google Scholar
Jakobsen ST, Jensen RAM, Madsen MS, Ravnsborg T, Vaagenso CS, Siersbæk MS, et al. MYC activity at enhancers drives prognostic transcriptional programs through an epigenetic switch. Nat Genet. 2024;56:663–74.
Article CAS PubMed Google Scholar
Guo J, Li T, Schipper J, Nilson KA, Fordjour FK, Cooper JJ, et al. Sequence specificity incompletely defines the genome-wide occupancy of Myc. Genome Biol. 2014;15:482.
Article PubMed PubMed Central Google Scholar
Sabò A, Amati B. Genome recognition by MYC. Cold Spring Harb Perspect Med. 2014;4:a014191.
Article PubMed PubMed Central Google Scholar
Walz S, Lorenzin F, Morton J, Wiese KE, von Eyss B, Herold S, et al. Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles. Nature. 2014;511:483–7.
Article CAS PubMed PubMed Central Google Scholar
Boija A, Klein IA, Sabari BR, Dall’Agnese A, Coffey EL, Zamudio AV, et al. Transcription factors activate genes through the phase-separation capacity of their activation domains. Cell. 2018;175:1842–55.e1816.
Article CAS PubMed Google Scholar
Yang J, Chung C-I, Koach J, Liu H, Navalkar A, He H, et al. MYC phase separation selectively modulates the transcriptome. Nat Struct Mol Biol. 2024;1–13.
Pellanda P, Dalsass M, Filipuzzi M, Loffreda A, Verrecchia A, Castillo Cano V, et al. Integrated requirement of non-specific and sequence-specific DNA binding in Myc-driven transcription. EMBO J. 2021;40:e105464.
Article CAS PubMed PubMed Central Google Scholar
Dang CV, O’Donnell KA, Zeller KI, Nguyen T, Osthus RC, Li F. The c-Myc target gene network. Semin Cancer Biol. 2006;16:253–64.
Article CAS PubMed Google Scholar
Lewis LM, Edwards MC, Meyers ZR, Talbot CC Jr., Hao H, Blum D, et al. Replication study: transcriptional amplification in tumor cells with elevated c-Myc. eLife. 2018;7:e30274.
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