Rupaimoole, R. & Slack, F. J. MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat. Rev. Drug Discov. 16, 203–222 (2017).
Article CAS PubMed Google Scholar
Slack, F. J. & Chinnaiyan, A. M. The role of non-coding RNAs in oncology. Cell 179, 1033–1055 (2019).
Article CAS PubMed PubMed Central Google Scholar
Slack, F. J. & Weidhaas, J. B. MicroRNA in cancer prognosis. N. Engl. J. Med. 359, 2720–2722 (2008).
Article CAS PubMed PubMed Central Google Scholar
Olejniczak, M., Galka, P. & Krzyzosiak, W. J. Sequence-non-specific effects of RNA interference triggers and microRNA regulators. Nucleic Acids Res. 38, 1–16 (2010).
Article CAS PubMed Google Scholar
Broderick, J. A. & Zamore, P. D. MicroRNA therapeutics. Gene Ther. 18, 1104–1110 (2011).
Article CAS PubMed PubMed Central Google Scholar
Boloix, A. et al. Engineering pH-sensitive stable nanovesicles for delivery of microRNA therapeutics. Small 18, e2101959 (2022).
van Rooij, E. & Olson, E. N. MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles. Nat. Rev. Drug Discov. 11, 860–872 (2012).
Article CAS PubMed PubMed Central Google Scholar
Zhou, H. et al. Stimuli-responsive nanotechnology for RNA delivery. Adv. Sci. 10, e2303597 (2023).
Li, S. et al. Advances in biological applications of self-assembled DNA tetrahedral nanostructures. Mater. Today. 24, 57–68 (2019).
Chen, Y. et al. DNA framework signal amplification platform-based high-throughput immune-cell phenotyping system for rapid systemic immune monitoring. Signal. Transduct. Target. Ther. 9, 28 (2024).
Madhanagopal, B. R. et al. DNA nanocarriers: programmed to deliver. Trends Biochem. Sci. 43, 997–1013 (2018).
Article CAS PubMed Google Scholar
Ge, Y. et al. Tetrahedral framework nucleic acids connected with microRNA-126 mimics for applications in vascular inflammation, remodeling, and homeostasis. ACS Appl. Mater. Interfaces 14, 19091–19103 (2022).
Article CAS PubMed Google Scholar
Li, J. et al. Modulation of the crosstalk between Schwann cells and macrophages for nerve regeneration: a therapeutic strategy based on a multifunctional tetrahedral framework nucleic acids system. Adv. Mater. 34, e2202513 (2022).
Qin, X. et al. Tetrahedral framework nucleic acids-based delivery of microRNA-155 inhibits choroidal neovascularization by regulating the polarization of macrophages. Bioact. Mater. 14, 134–144 (2022).
Zhang, M. et al. Transcutaneous immunotherapy for RNAi: a cascade-responsive decomposable nanocomplex based on polyphenol-mediated framework nucleic acid in psoriasis. Adv. Sci. 10, e2303706 (2023).
Tian, T. et al. A dynamic DNA tetrahedron framework for active targeting. Nat. Protoc. 18, 1028–1055 (2023).
Article CAS PubMed Google Scholar
Zhang, T. et al. Design, fabrication and applications of tetrahedral DNA nanostructure-based multifunctional complexes in drug delivery and biomedical treatment. Nat. Protoc. 15, 2728–2757 (2020).
Article CAS PubMed Google Scholar
Cerritelli, S. M. & Crouch, R. J. Ribonuclease H: the enzymes in eukaryotes. FEBS J. 276, 1494–1505 (2009).
Article CAS PubMed Google Scholar
Ohle, C. et al. Transient RNA–DNA hybrids are required for efficient double-strand break repair. Cell 167, 1001–1013 (2016).
Article CAS PubMed Google Scholar
Li, S. et al. Bioswitchable delivery of microRNA by framework nucleic acids: application to bone regeneration. Small 17, e2104359 (2021).
Li, S. et al. A tetrahedral framework DNA-based bioswitchable miRNA inhibitor delivery system: application to skin anti-aging. Adv. Mater. 34, e2204287 (2022).
Jiang, Y. et al. A novel bioswitchable miRNA mimic delivery system: therapeutic strategies upgraded from tetrahedral framework nucleic acid system for fibrotic disease treatment and pyroptosis pathway inhibition. Adv. Sci. 11, e2305622 (2023).
Afonin, K. A. et al. Triggering of RNA interference with RNA–RNA, RNA–DNA, and DNA–RNA nanoparticles. ACS Nano. 9, 251–259 (2015).
Article CAS PubMed Google Scholar
Gavette, J. V. et al. RNA–DNA chimeras in the context of an RNA world transition to an RNA/DNA world. Angew. Chem. Int. Ed. Engl. 55, 13204–13209 (2016).
Article CAS PubMed Google Scholar
Li, S. et al. MicroRNA-214-3p modified tetrahedral framework nucleic acids target survivin to induce tumour cell apoptosis. Cell Prolif. 53, e12708 (2020).
Lee, H. et al. Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery. Nat. Nanotechnol. 7, 389–393 (2012).
Article CAS PubMed PubMed Central Google Scholar
Gao, Y. et al. A lysosome-activated tetrahedral nanobox for encapsulated siRNA delivery. Adv. Mater. 34, e2201731 (2022).
Wiraja, C. et al. Framework nucleic acids as programmable carrier for transdermal drug delivery. Nat. Commun. 10, 1147–1159 (2019).
Article PubMed PubMed Central Google Scholar
Ding, H. et al. DNA nanostructure-programmed like-charge attraction at the cell-membrane interface. ACS Cent. Sci. 4, 1344–1351 (2018).
Article CAS PubMed PubMed Central Google Scholar
Li, J. et al. The neuroprotective effect of microRNA-22-3p modified tetrahedral framework nucleic acids on damaged retinal neurons via TrkB/BDNF signaling pathway. Adv. Funct. Mater. 31, 2104141 (2021).
Liang, L. et al. Single-particle tracking and modulation of cell entry pathways of a tetrahedral DNA nanostructure in live cells. Angew. Chem. Int. Ed. Engl. 53, 7745–7750 (2014).
Article CAS PubMed Google Scholar
Shi, S. et al. Biological effect of differently sized tetrahedral framework nucleic acids: endocytosis, proliferation, migration, and biodistribution. ACS Appl. Mater. Interfaces 13, 57067–57074 (2021).
Article CAS PubMed Google Scholar
Tian, T. et al. Liver-targeted delivery of small interfering RNA of C–C chemokine receptor 2 with tetrahedral framework nucleic acid attenuates liver cirrhosis. ACS Appl. Mater. Interfaces 15, 10492–10505 (2023).
Article CAS PubMed Google Scholar
Qin, X. et al. Tetrahedral-framework nucleic acid loaded with microRNA-155 enhances immunocompetence in cyclophosphamide-induced immunosuppressed mice by modulating dendritic cells and macrophages. ACS Appl. Mater. Interfaces 15, 7793–7803 (2023).
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