Abdali N, Parks JM, Haynes KM et al (2017) Reviving antibiotics: efflux pump inhibitors that interact with AcrA, a membrane fusion protein of the AcrAB-TolC multidrug efflux pump. ACS Infect Dis 3:89–98. https://doi.org/10.1021/acsinfecdis.6b00167
Article CAS PubMed Google Scholar
Abu-Sini M, Mayyas A, Al-Karablieh N et al (2017) Synthesis of 1, 2, 3-triazolo [4, 5-h] quinolone derivatives with novel anti-microbial properties against Metronidazole resistant Helicobacter pylori. Molecules 22:841. https://doi.org/10.3390/molecules22050841
Article CAS PubMed PubMed Central Google Scholar
Al-Hadid KJ, Al-Karablieh N, Sharab A, Mutlak I (2019) Phytochemical analyses and antibacterial activities of Erodium, Euphorbia, Logoecia and Tamarix species. J Infect Dev Ctries 13:1013–1020. https://doi.org/10.3855/JIDC.11776
Article CAS PubMed Google Scholar
Al-Karablieh N, Weingart H, Ullrich MS (2009a) Genetic exchange of multidrug efflux pumps among two enterobacterial species with distinctive ecological niches. Int J Mol Sci 10:629–645. https://doi.org/10.3390/ijms10020629
Article CAS PubMed PubMed Central Google Scholar
Al-Karablieh N, Weingart H, Ullrich MS (2009b) The outer membrane protein TolC is required for phytoalexin resistance and virulence of the fire blight pathogen Erwinia amylovora. Microb Biotechnol 2:465–475. https://doi.org/10.1111/j.1751-7915.2009.00095.x
Article CAS PubMed PubMed Central Google Scholar
Bavro VN, Pietras Z, Furnham N et al (2008) Assembly and channel opening in a bacterial drug efflux machine. Mol Cell 30:114–121. https://doi.org/10.1016/j.molcel.2008.02.015
Article CAS PubMed PubMed Central Google Scholar
Bergmiller T, Andersson AMC, Tomasek K et al (2017) Biased partitioning of the multidrug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity. Sci (80-) 356:311–315. https://doi.org/10.1126/science.aaf4762
Blanco P, Hernando-Amado S, Reales-Calderon JA et al (2016) Bacterial multidrug efflux pumps: much more than antibiotic resistance determinants. Microorganisms 4:14. https://doi.org/10.3390/microorganisms4010014
Article CAS PubMed PubMed Central Google Scholar
Burse A, Weingart H, Ullrich MS (2004) NorM, an Erwinia amylovora multidrug efflux pump involved in in vitro competition with other epiphytic bacteria. Appl Environ Microbiol 70:693–703. https://doi.org/10.1128/AEM.70.2.693-703.2004
Article CAS PubMed PubMed Central Google Scholar
Coldham NG, Webber M, Woodward MJ, Piddock LJV (2010) A 96-well plate fluorescence assay for assessment of cellular permeability and active efflux in Salmonella enterica Serovar Typhimurium and Escherichia coli. J Antimicrob Chemother 65:1655–1663. https://doi.org/10.1093/jac/dkq169
Article CAS PubMed Google Scholar
Du D, Wang Z, Chiu W, Luisi BF (2018) Purification of AcrAB-TolC Multidrug Efflux Pump for Cryo-EM analysis. Bact Multidrug Export Methods Protoc 71–81. https://doi.org/10.1007/978-1-4939-7454-2_5
Elkins CA, Nikaido H (2003) 3D structure of AcrB: the archetypal multidrug efflux transporter of Escherichia coli likely captures substrates from periplasm. Drug Resist Updat 6:9–13. https://doi.org/10.1016/s1368-7646(03)00004-9
Article CAS PubMed Google Scholar
Gupta D, Singh A, Khan AU (2017) Nanoparticles as efflux pump and biofilm inhibitor to rejuvenate bactericidal effect of conventional antibiotics. Nanoscale Res Lett 12:1–6. https://doi.org/10.1186/s11671-017-2222-6
Jaradat DMM (2018) Thirteen decades of peptide synthesis: key developments in solid phase peptide synthesis and amide bond formation utilized in peptide ligation. Amino Acids 50:39–68. https://doi.org/10.1007/s00726-017-2516-0
Article CAS PubMed Google Scholar
Jaradat DMM (2022) Solid-phase peptide cyclization with two Disulfide bridges. Methods Mol Biol 2371:19–29. https://doi.org/10.1007/978-1-0716-1689-5_2
Article CAS PubMed Google Scholar
Jaradat DMM, Saleh KKY, Za’arir BHM et al (2019) Solid-phase synthesis and antibacterial activity of an Artificial cyclic peptide containing two Disulfide bridges. Int J Pept Res Ther 25:1095–1102. https://doi.org/10.1007/s10989-018-9757-y
Jaradat DMM, Al-Karablieh N, Zaarer BHM et al (2021) Human glucose-dependent insulinotropic polypeptide (GIP) is an antimicrobial adjuvant re-sensitising multidrug-resistant Gram-negative bacteria. Biol Chem 402:513–524. https://doi.org/10.1515/hsz-2020-0351
Article CAS PubMed Google Scholar
Jeong H, Kim J-S, Song S et al (2016) Pseudoatomic structure of the tripartite multidrug efflux pump AcrAB-TolC reveals the intermeshing cogwheel-like interaction between AcrA and TolC. Structure 24:272–276. https://doi.org/10.1016/j.str.2015.12.007
Article CAS PubMed Google Scholar
Kim H-M, Xu Y, Lee M et al (2010) Functional relationships between the AcrA hairpin tip region and the TolC aperture tip region for the formation of the bacterial tripartite efflux pump AcrAB-TolC. J Bacteriol 192:4498–4503. https://doi.org/10.1128/JB.00334-10
Article CAS PubMed PubMed Central Google Scholar
Kim J-S, Jeong H, Song S et al (2015) Structure of the tripartite multidrug efflux pump AcrAB-TolC suggests an alternative assembly mode. Mol Cells 38:180–186. https://doi.org/10.14348/molcells.2015.2277
Article CAS PubMed PubMed Central Google Scholar
Krishnamoorthy G, Tikhonova EB, Dhamdhere G, Zgurskaya HI (2013) On the role of TolC in multidrug efflux: the function and assembly of AcrAB–TolC tolerate significant depletion of intracellular TolC protein. Mol Microbiol 87:982–997. https://doi.org/10.1111/mmi.12143
Article CAS PubMed PubMed Central Google Scholar
Lewis K (2001) In search of natural substrates and inhibitors of MDR pumps. J Mol Microbiol Biotechnol 3:247–254
Lomovskaya O, Warren MS, Lee A et al (2001) Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob Agents Chemother 45:105–116. https://doi.org/10.1128/aac.45.1.105-116.2001
Article CAS PubMed PubMed Central Google Scholar
Mayyas A, Azzam H, Tayseer I et al (2021) Evaluation of the synergistic antimicrobial effect of folk medicinal plants with clindamycin against methicillin-resistant Staphylococcus aureus strains. Lett Appl Microbiol 73:735–740. https://doi.org/10.1111/lam.13565
Article CAS PubMed Google Scholar
Nikaido H (2011) Structure and mechanism of RND-type multidrug efflux pumps. Adv Enzymol Relat Areas Mol Biol 77:1. https://doi.org/10.1002/9780470920541.ch1
Article CAS PubMed PubMed Central Google Scholar
Nikaido H, Takatsuka Y (2009) Mechanisms of RND multidrug efflux pumps. Biochim Biophys Acta (BBA)-Proteins Proteom 1794:769–781. https://doi.org/10.1016/j.bbapap.2008.10.004
Opperman TJ, Nguyen ST (2015) Recent advances toward a molecular mechanism of efflux pump inhibition. Front Microbiol 6:140720. https://doi.org/10.3389/fmicb.2015.00421
Pagès J-M, Amaral L (2009) Mechanisms of drug efflux and strategies to combat them: challenging the efflux pump of Gram-negative bacteria. Biochim Biophys Acta (BBA)-Proteins Proteom 1794:826–833. https://doi.org/10.1016/j.bbapap.2008.12.011
留言 (0)