Wang W, Gawlik K, Lopez J, Wen C, Zhu J, Wu F et al (2016) Genetic and environmental factors strongly influence risk, severity and progression of age-related macular degeneration. Sig Transduct Target Ther 1(1):16016

Article  Google Scholar 

Deangelis MM, Silveira AC, Carr EA, Kim IK (2011) Genetics of age-related macular degeneration: current concepts, future directions. Semin Ophthalmol 26(3):77–93

Article  PubMed  PubMed Central  Google Scholar 

Wong WL, Su X, Li X, Cheung CM, Klein R, Cheng CY et al (2014) Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health 2(2):e106–e116

Article  PubMed  Google Scholar 

Cheung CM, Tai ES, Kawasaki R, Tay WT, Lee JL, Hamzah H et al (2012) Prevalence of and risk factors for age-related macular degeneration in a multiethnic Asian cohort. Arch Ophthal 130(4):480–486

Article  PubMed  Google Scholar 

Kuo JZ, Wong TY, Ong FS (2013) Genetic risk, ethnic variations and pharmacogenetic biomarkers in age-related macular degeneration and polypoidal choroidal vasculopathy. Expert Rev Ophthalmol 8(2):127–140

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang Z, Camp NJ, Sun H, Tong Z, Gibbs D, Cameron DJ et al (2006) A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science 314(5801):992–993

Article  CAS  PubMed  Google Scholar 

DeWan A, Liu M, Hartman S, Zhang SS-M, Liu DTL, Zhao C et al (2006) HTRA1 promoter polymorphism in wet age-related macular degeneration. Science 314(5801):989

Article  CAS  PubMed  Google Scholar 

Mohamedmohaideen NN, Palaninathan SK, Morin PM, Williams BJ, Braunstein M, Tichy SE et al (2008) Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis. Biochemistry 47(23):6092–6102

Article  CAS  PubMed  Google Scholar 

Supanji, Shimomachi M, Hasan MZ, Kawaichi M, Oka C (2013) HTRA1 is induced by oxidative stress and enhances cell senescence through p38 MAPK pathway. Exp Eye Res 112:79–92

Article  CAS  PubMed  Google Scholar 

Clausen T, Southan C, Ehrmann M (2002) The HTRA family of proteases: Implications for protein composition and cell fate. Mol Cell 10(3):443–455

Article  CAS  PubMed  Google Scholar 

Micklisch S, Lin Y, Jacob S, Karlstetter M, Dannhausen K, Dasari P et al (2017) Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator. J Neuroinflam 14(1):4

Article  Google Scholar 

Kanda A, Chen W, Othman M, Branham KE, Brooks M, Khanna R et al (2007) A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. PNAS 104(41):16227–16232

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kortvely E, Hauck SM, Duetsch G, Gloeckner CJ, Kremmer E, Alge-Priglinger CS et al (2010) ARMS2 is a constituent of the extracellular matrix providing a link between familial and sporadic age-related macular degenerations. Invest Ophthalmol Vis Sci 51(1):79–88

Article  PubMed  Google Scholar 

Age-Related Eye Disease Study Research Group (2001) A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthal 119(10):1417–1436

Article  Google Scholar 

Xu Y, Guan N, Xu J, Yang X, Ma K, Zhou H et al (2008) Association of CFH, LOC387715, and HTRA1 polymorphisms with exudative age-related macular degeneration in a northern Chinese population. Mol Vis 14:1373–1381

CAS  PubMed  PubMed Central  Google Scholar 

Rousset F (2008) Genepop’007: a complete re-implementation of the genepop software for Windows and Linux. Mol Ecol Resour 8(1):103–106

Article  PubMed  Google Scholar 

Purcell S, Cherny SS, Sham PC (2003) Genetic power calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19(1):149–150

Article  CAS  PubMed  Google Scholar 

Sundaresan P, Vashist P, Ravindran RD, Shanker A, Nitsch D, Nonyane BA et al (2012) Polymorphisms in ARMS2/HTRA1 and complement genes and age-related macular degeneration in India: findings from the INDEYE study. Invest Ophthalmol Vis Sci 53(12):7492–7497

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tian J, Yu W, Qin X, Fang K, Chen Q, Hou J et al (2012) Association of genetic polymorphisms and age-related macular degeneration in Chinese population. Invest Ophthalmol Vis Sci 53(7):4262–4269

Article  CAS  PubMed  Google Scholar 

Kaur I, Katta S, Hussain A, Hussain N, Mathai A, Narayanan R et al (2008) Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients. Invest Ophthalmol Vis Sci 49(5):1771–1776

Article  PubMed  Google Scholar 

Mohamad NA, Ramachandran V, Mohd Isa H, Chan YM, Ngah NF, Ching SM et al (2019) Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects. Hum Genomics 13(1):13

Article  PubMed  PubMed Central  Google Scholar 

Conroy SW, Supanji M, Sasongko BM (2018) Identifikasi single nucleotide polymorphism (SNP) gen HTRA1 pada age- related macular degeneration (AMD) di Indonesia: Studi deskriptif: Universitas Gadjah Mada

Ruamviboonsuk P, Tadarati M, Singhanetr P, Wattanapokayakit S, Kunhapan P, Wanitchanon T et al (2017) Genome-wide association study of neovascular age-related macular degeneration in the Thai population. J Hum Genet 62(11):957–962

Article  PubMed  Google Scholar 

Mori K, Horie-Inoue K, Kohda M, Kawasaki I, Gehlbach PL, Awata T et al (2007) Association of the HTRA1 gene variant with age-related macular degeneration in the Japanese population. J Hum Genet 52(7):636–641

Article  CAS  PubMed  Google Scholar 

Ng TK, Liang XY, Lai TYY, Ma L, Tam POS, Wang JX et al (2016) HTRA1 promoter variant differentiates polypoidal choroidal vasculopathy from exudative age-related macular degeneration. Sci Rep 6(1):28639

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee SJ, Kim NR, Chin HS (2010) LOC387715/HTRA1 polymorphisms, smoking and combined effects on exudative age-related macular degeneration in a Korean population. Clin Exp Ophthalmol 38(7):698–704

Article  PubMed  Google Scholar 

Jiang H, Qu Y, Dang G, Zhang X, Yin N, Zhang Y et al (2009) Analyses of single nucleotide polymorphisms and haplotype linkage of LOC387715 and the HTRA1 gene in exudative age-related macular degeneration in a Chinese cohort. Retina 29(7):974–979

Article  PubMed  Google Scholar 

Matušková V, Zeman T, Ewerlingová L, Hlinomazová Z, Souček J, Vlková E et al (2020) An association of neovascular age-related macular degeneration with polymorphisms of CFH, ARMS2, HTRA1 and C3 genes in Czech population. Acta Ophthalmol. https://doi.org/10.1111/aos.14357

Article  PubMed  Google Scholar 

Weger M, Renner W, Steinbrugger I, Köfer K, Wedrich A, Groselj-Strele A et al (2007) Association of the HTRA1 -625G>A promoter gene polymorphism with exudative age-related macular degeneration in a Central European population. Mol Vis 13:1274–1279

CAS  PubMed  Google Scholar 

Liutkeviciene R, Vilkeviciute A, Gedvilaite G, Kaikaryte K, Kriauciuniene L (2019) Haplotypes of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 gene polymorphisms in age-related macular degeneration. Dis Mark 2019:9602949

Google Scholar 

Chowers I, Cohen Y, Goldenberg-Cohen N, Vicuna-Kojchen J, Lichtinger A, Weinstein O et al (2008) Association of complement factor H Y402H polymorphism with phenotype of neovascular age related macular degeneration in Israel. Mol Vis 14:1829–1834

CAS  PubMed  PubMed Central  Google Scholar 

Tanimoto S, Tamura H, Ue T, Yamane K, Maruyama H, Kawakami H et al (2007) A polymorphism of LOC387715 gene is associated with age-related macular degeneration in the Japanese population. Neurosci Lett 414(1):71–74

Article  CAS  PubMed  Google Scholar