Computational approaches identify a transcriptomic fingerprint of drug-induced structural cardiotoxicity

Aguet F, Anand S, Ardlie KG, Gabriel S, Getz GA, Graubert A, Hadley K, Handsaker RE, Huang KH, Kashin S, Li X, MacArthur DG, Meier SR, Nedzel JL, Nguyen DT, Segrè AV, Todres E, Balliu B, Barbeira AN, et al. The GTEx consortium atlas of genetic regulatory effects across human tissues. Science. 2020;369(6509):1318–30. https://doi.org/10.1126/science.aaz1776.

Article  CAS  Google Scholar 

Andersson L, Cinato M, Mardani I, Miljanovic A, Arif M, Koh A, Lindbom M, Laudette M, Bollano E, Omerovic E, Klevstig M, Henricsson M, Fogelstrand P, Swärd K, Ekstrand M, Levin M, Wikström J, Doran S, Hyötyläinen T, et al. Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking. Eur Heart J. 2021;42(43):4481–92. https://doi.org/10.1093/EURHEARTJ/EHAB412.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Archer CR, Sargeant R, Basak J, Pilling J, Barnes JR, Pointon A. Characterization and validation of a human 3D cardiac microtissue for the assessment of changes in cardiac pathology. Sci Rep. 2018;8(1):1–15. https://doi.org/10.1038/s41598-018-28393-y.

Article  CAS  Google Scholar 

Arnett DK, Devereux RB, Rao DC, Li N, Tang W, Kraemer R, Claas SA, Leon JM, Broeckel U. Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study. J Hypertens. 2009;27(8):1585–93. https://doi.org/10.1097/HJH.0b013e32832be612.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baik B, Yoon S, Nam D. Benchmarking RNA-seq differential expression analysis methods using spike-in and simulation data. PLoS One. 2020;15(4) https://doi.org/10.1371/JOURNAL.PONE.0232271.

Billingham ME, Mason JW, Bristow MR, Daniels JR. Anthracycline cardiomyopathy monitored by morphologic changes. Cancer Treat Rep. 1978;62(6):865–72.

CAS  PubMed  Google Scholar 

Brandão SR, Carvalho F, Amado F, Ferreira R, Costa VM. Insights on the molecular targets of cardiotoxicity induced by anticancer drugs: a systematic review based on proteomic findings. Metab Clin Exp. 2022:134. https://doi.org/10.1016/J.METABOL.2022.155250.

Cartledge JE, Kane C, Dias P, Tesfom M, Clarke L, Mckee B, Al Ayoubi S, Chester A, Yacoub MH, Camelliti P, Terracciano CM. Functional crosstalk between cardiac fibroblasts and adult cardiomyocytes by soluble mediators. Cardiovascular Research. 2015;105(3):260–70. https://doi.org/10.1093/CVR/CVU264.

Article  CAS  PubMed  Google Scholar 

Chaudhari U, Nemade H, Wagh V, Gaspar JA, Ellis JK, Srinivasan SP, Spitkovski D, Nguemo F, Louisse J, Bremer S, Hescheler J, Keun HC, Hengstler JG, Sachinidis A. Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment. Arch Toxicol. 2016;90(11):2763–77. https://doi.org/10.1007/S00204-015-1623-5.

Article  CAS  PubMed  Google Scholar 

Cho ES, Cha YH, Kim HS, Kim NH, Yook JI. The pentose phosphate pathway as a potential target for cancer therapy. Biomol Ther. 2018;26(1):29–38. https://doi.org/10.4062/biomolther.2017.179.

Article  CAS  Google Scholar 

Connell P, Word TA, Wehrens XHT. Targeting pathological leak of ryanodine receptors: preclinical progress and the potential impact on treatments for cardiac arrhythmias and heart failure. Expert Opin Ther Targets. 2020;24(1):25–36. https://doi.org/10.1080/14728222.2020.1708326.

Article  CAS  PubMed  Google Scholar 

Crisci S, Amitrano F, Saggese M, Muto T, Sarno S, Mele S, Vitale P, Ronga G, Berretta M, Di Francia R. Overview of current targeted anti-cancer drugs for therapy in onco-hematology. Medicina (Kaunas, Lithuania). 2019;55(8) https://doi.org/10.3390/MEDICINA55080414.

DeGroat W, Abdelhalim H, Patel K, Mendhe D, Zeeshan S, Ahmed Z. Discovering biomarkers associated and predicting cardiovascular disease with high accuracy using a novel nexus of machine learning techniques for precision medicine. Sci Rep. 2024;14(1):1–13. https://doi.org/10.1038/s41598-023-50600-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deidda M, Mercurio V, Cuomo A, Noto A, Mercuro G, Dessalvi CC. Metabolomic perspectives in antiblastic cardiotoxicity and cardioprotection. Int J Mol Sci. 2019;20(19) https://doi.org/10.3390/IJMS20194928.

Doenst T, Nguyen TD, Abel ED. Cardiac metabolism in heart failure: implications beyond ATP production. Circ Res. 2013;113(6):709–24. https://doi.org/10.1161/CIRCRESAHA.113.300376.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eder P, Molkentin JD. TRPC channels as effectors of cardiac hypertrophy. Circ Res. 2011;108(2):265–72. https://doi.org/10.1161/CIRCRESAHA.110.225888.

Article  CAS  PubMed  Google Scholar 

Geisberg CA, Sawyer DB. Mechanisms of anthracycline cardiotoxicity and strategies to decrease cardiac damage. Curr Hypertens Rep. 2010;12(6):404–10. https://doi.org/10.1007/S11906-010-0146-Y/METRICS.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Glaab WE, Holder D, He YD, Bailey WJ, Gerhold DL, Beare C, Erdos Z, Lane P, Michna L, Muniappa N, Lawrence JW, Tanis KQ, Sina JF, Skopek TR, Sistare FD. Universal toxicity gene signatures for early identification of drug-induced tissue injuries in rats. Toxicol Sci. 2021;181(2):148–59. https://doi.org/10.1093/TOXSCI/KFAB038.

Article  CAS  PubMed  Google Scholar 

Grafton F, Ho J, Ranjbarvaziri S, Farshidfar F, Budan A, Steltzer S, Maddah M, Loewke KE, Green K, Patel S, Hoey T, Mandegar MA. Deep learning detects cardiotoxicity in a high-content screen with induced pluripotent stem cell-derived cardiomyocytes. ELife. 2021:10. https://doi.org/10.7554/ELIFE.68714.

Guo F, Hall AR, Tape CJ, Ling S, Pointon A. Intra- and intercellular signaling pathways associated with drug-induced cardiac pathophysiology. Trends in Pharmacological Sciences. 2021;42(8):675–87. https://doi.org/10.1016/J.TIPS.2021.05.004.

Article  CAS  PubMed  Google Scholar 

Hedin U, Thyberg J, Roy J, Dumitrescu A, Tran PK. Role of tyrosine kinases in extracellular matrix-mediated modulation of arterial smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol. 1997;17(10):1977–84. https://doi.org/10.1161/01.ATV.17.10.1977.

Article  CAS  PubMed  Google Scholar 

Hortobágyi GN. Anthracyclines in the treatment of cancer. An overview. Drugs. 1997;54(SUPPL. 4):1–7. https://doi.org/10.2165/00003495-199700544-00003/METRICS.

Article  PubMed  Google Scholar 

Jacques D, Sader S, Perreault C, Fournier A, Pelletier G, Beck-Sickinger AG, Descorbeth M. Presence of neuropeptide Y and the Y1 receptor in the plasma membrane and nuclear envelope of human endocardial endothelial cells: modulation of intracellular calcium. Can J Physiol Pharmacol. 2003;81(3):288–300. https://doi.org/10.1139/y02-165.

Article  CAS  PubMed  Google Scholar 

Kanemaru K, Cranley J, Muraro D, Miranda AMA, Ho SY, Wilbrey-Clark A, Patrick Pett J, Polanski K, Richardson L, Litvinukova M, Kumasaka N, Qin Y, Jablonska Z, Semprich CI, Mach L, Dabrowska M, Richoz N, Bolt L, Mamanova L, et al. Spatially resolved multiomics of human cardiac niches. Nature. 2023;619(7971):801–10. https://doi.org/10.1038/s41586-023-06311-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karakikes I, Ameen M, Termglinchan V, Wu JC. Human induced pluripotent stem cell-derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes. Circ Res. 2015;117(1):80–8. https://doi.org/10.1161/CIRCRESAHA.117.305365.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karlsson M, Zhang C, Méar L, Zhong W, Digre A, Katona B, Sjöstedt E, Butler L, Odeberg J, Dusart P, Edfors F, Oksvold P, von Feilitzen K, Zwahlen M, Arif M, Altay O, Li X, Ozcan M, Mardinoglu A, et al. A single-cell type transcriptomics map of human tissues. Sci Adv. 2021;7(31) https://doi.org/10.1126/sciadv.abh2169.

Krämer A, Green J, Pollard J, Tugendreich S. Causal analysis approaches in Ingenuity Pathway Analysis. Bioinformatics. 2014;30(4):523–30. https://doi.org/10.1093/BIOINFORMATICS/BTT703.

Article  PubMed  Google Scholar 

Lamore SD, Ahlberg E, Boyer S, Lamb ML, Hortigon-Vinagre MP, Rodriguez V, Smith GL, Sagemark J, Carlsson L, Bates SM, Choy AL, Stålring J, Scott CW, Peters MF. Deconvoluting Kinase Inhibitor Induced Cardiotoxicity. Toxicol Sci. 2017;158(1):213–26. https://doi.org/10.1093/TOXSCI/KFX082.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9(1):559. https://doi.org/10.1186/1471-2105-9-559.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Laverty HG, Benson C, Cartwright EJ, Cross MJ, Garland C, Hammond T, Holloway C, McMahon N, Milligan J, Park BK, Pirmohamed M, Pollard C, Radford J, Roome N, Sager P, Singh S, Suter T, Suter W, Trafford A, et al. How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines? Br J Pharmacol. 2011;163(4):675. https://doi.org/10.1111/J.1476-5381.2011.01255.X.

Article  CAS  PubMed  PubMed Central 

留言 (0)

沒有登入
gif